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Please login to access the full content or check if you have access via Variation 1: Zirconium-Catalyzed Carboalumination of Alkynes

DOI: 10.1055/sos-SD-002-00797

Negishi, E.-i.; Takahashi, T.Science of Synthesis, (20032732.

Aside from the ZieglerNatta and related alkene polymerization reactions, the monocarboalumination reaction of alkynes with organoaluminums, e.g. trimethylaluminum, dimethylaluminum chloride, and diethylaluminum chloride, catalyzed by dichlorobis(η5-cyclopentadienyl)zirconium(IV) (49),[‌184‌,‌185‌] appears to have been the first zirconium-catalyzed carbometalation reaction. In addition to the simple alkylaluminums mentioned above, organoaluminums containing allyl,[‌186‌] benzyl,[‌187‌] and various heteroatom-containing substituents, e.g. hydroxy, iodo, and phenylsulfanyl groups, have been successfully employed, e.g. formation of 137-140 (Scheme 63).

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