Science of Synthesis

Negishi, E.-i.; Takahashi, T., Science of Synthesis, (2003) 2, 801.

Taking into account new and elevated mechanistic perspectives, the mechanisms of zirconium-catalyzed ethyl- and higher alkylaluminations of alkynes first reported in 1978 have been reinvestigated,[‌184‌,‌185‌] and some of the most intricate and intriguing mechanistic details have been disclosed.[‌188‌,‌383‌] In the intervening years, some zirconium-catalyzed cyclic carboalumination reactions of alkenes have also been reported.[‌384‌]

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‌Meeeee 888‌ Meeee Meeeeeee Meeeeeeee ee Mee-8-eee eeee Meeeeeeeeeeeeeee[‌888‌]

‌Meeeee 888‌ Mee Meeeeeeeeeeeee Meeeeeee ee Meeeeeeee(η8-eeeeeeeeeeeeeeee)eeeeeeeeeeee­ee(MM) eeee Meeeeeeeeeeeeeee[‌888‌]

‌Meeeee 888‌ Meeeeeee ee Mee-8-eee eeee e Meee-Meeeeeee Meeeeeeeeeeeeeeeeee[‌888‌]

Me eeeeeeeee eeeee, eee eeeeeeeee ee eeeeeee eeee eeeeeeeeeeeeeeee eeeeeeeee ee eeeeeeeeeee(η8-eeeeeeeeeeeeeeee)eeeeeeeee(MM) (‌88‌) ee e eeeeee eeeeeee eeeee eeeeeeeee eee eeee eeeeeeeeee eeee eeeeeeeeeee, eeeeeee eee eeeeeeeeeeeee eeeeeeee eeee eeeeeee­eeeeeeee eeeeeeee ee eeeeeee. Me eeee, eee eeeeee eeeeeeee eeeeee ee eeeeeee eeee ee 8,8-eeeeeeeeeeeeee, eeeeeee eee eeeeeeee ee eeee eeee eee eeeeee. Meee eeeeeeeeeeeeee eeeeeeeeee eeeeee ee e eeeeee eeeee eeeeee, eee eeeeee eeeeeeeeeeeeeeee eeeeeee eeee eeeeeeeee eeeeeeeeeeeeeeee eee eeeeee eeeeeeeeeeee eeeeeeeee. Meeeeee ee eeeee eeee eeeeeeeee ee eeeeeeeeee ee eee eeeeeee eeeeeeeeeeeeeeee eeee eeeeeeeeeeeeeeee eeeeeeee. Me eeee eeeeee eee eeeeeee eeeeeeeee, eee eeeeeeeeeeeeeeee eee eeee eee, eee eeee eeeeeeeeee eeee eeee ee ee eeeeeeee eeeeee eeeee eeeeeeeeeeeeeeee eeeeeeeee eeeeee ee eeee eeeeeeeee eeeeeee; eeeeeee, eeeeeee eeeeeeeeee eee eee eeeeee-, eeeee-, eee eeeeeeeeeeeeeeeee eeeeeeeee eeeeeeeee ee Meeeeee ‌8.88.8.8.8.8‌. Meeee eeeeee eee eeeeeee eeeeeeeeeee ee eee eeeeeee eeeeeeeeee ee ‌Meeee 88‌.[‌888‌]

‌Meeee 88‌ Meeeeeeee-Meeeeeeee Meeeeeeeeeeeeeee ee Meeeeee[‌888‌]

Meeeee­eeeeeeee ­Meeeeee			Meeeeee	Meeeee ee Meeeeeeeeeee Meeeeeeee,e (%)			Mee
	M8	M8				Meeee Meeeeeee
Me8Me	Me	Me	eeeeee	88 (>88% M)	e.e.	e.e.	[‌888‌]
Me8Me	Me	Me	eeeeeee	88 (>88% M)	e.e.	88 (≥ 88% M)	[‌888‌]
Me8Me	(MM8)8Me	M	eeeeeee	88 (>88% M) 88 (>88% M)	e.e.	e.e.	[‌888‌]
Me8Me	Me	M	eeeeee	88 (>88% M) 88 (>88% M)	e.e.	e.e.	[‌888‌]
Me8MeMee	Me	Me	MeMM8MM8Me	e.e.	88 (>88% M)	8 (≥88% M)	[‌888‌]
Me8MeMee	(MM8)8Me	M	MeMM8MM8Me	e.e.	88 (>88% M) >88 (88 eee 88% M)	e.e.	[‌888‌]

e Me MMM eeeeeeeeeeee ee MMM.

e e.e. = eee eeeeeeee.

e Mee eeeeeeee ee eeeeeee ee ee eeeeeee, eee eee eeeeeee eee eeeeeeee eee eeeeeeeeee.

Mee eeeeeeee ee eee-8-eeee eeee eeeeeeeeeeeeeeee ee eee eeeeeeee ee e eeeeeeeee eeeeee ee eeeeeeeeeee(η8-eeeeeeeeeeeeeeee)eeeeeeeee(MM) (‌88‌) eeeee eee eeeeeeeeeeeee eeeeeeeeeeeeeeeeeeee ‌888‌ ee eeeee eee eee-8-eee eee eeeeee eeeeeee eeee eeeeeeeeeeeeeeee eee eeeee eeeeeee. Meeeeeee ee eeeeeeeeeeeeeeeeeeee ‌888‌ eeee eeeeeeeee eeeee ee eeeeee eeeee eeeeeee ‌888‌ eee ‌888‌, eeeeeeeeeeee (‌Meeeee 888‌).[‌888‌,‌888‌]

‌Meeeee 888‌ Meeeeeeee-Meeeeeeee Meeeeeeeeeeeeeee ee Mee-8-eeee[‌888‌,‌888‌]

Meee eeeeee eeeeeeeeeeeeee eee eee-8-eeee, eeeeeeee ee ee eeeee e eee eeeeeeee eee eeeeeeee. Meeeeeeee, eee eeeeeee eeeee ee eeeeeeeeeeeee eeeeee eeeeeeeee-eeeeeeeee eeeeee eeeeeeeeeeeeeeee eeeeeeeee ee eeeeeeeeeee eeeeeee ee eeeeeeeeeeeeeeee.

Meeeee eee eeee eeeeeeee ee eee eeeeeeeee-eeeeeeeee eeeeeeeeeeeeeeee eeeeee eeeeeeeeeeeeeeee ee eeeeee eee-8-eeee, eeee ee ‌888‌, eeeeeee e eeeeeeeeee-eeeeeeeeee eeeeeeeeee eeeee. Me eee eeee eeeeeeee eeee, e eeeeee eeeeeeeeeeee eeeeee ee 88% ee eeeeeeee ee eeeee eeeeeeee eeee eee eeeeeeeee-eeeeeeeee eeeeeeeeeeeeeeee eeeeeee eeeeeeeeeeeeeeee (eee ‌Meeeee 88‌).[‌888‌]

Me e eeeeeee eeeeee ee eee eeeee eeeee eeee eeee eeee eeeeeeee, eeeee eee ee eee eeeeeeeeee eee eeeee eeeeee, e.e. ‌888‌, eee eeeeeeee, e.e. ‌888‌, eeee eeeeeeeeeee eeeeeeeeeeee eeeeeeee eeee eeee eeeeeeee, e.e. ee eee eeeeeeeee ee ‌888‌ eee ‌888‌, eee ‌888‌, eeeeeeeeeeee (‌Meeeee 888‌).[‌888‌,‌888‌]

‌Meeeee 888‌ Meeeeeeee-Meeeeeeee Meeeeeeeeeeeeeee Meeeeeeeee ee Meeee Meeeee eee Meeee Meeeeeee[‌88‌,‌888‌,‌888‌]

‌Meeeeeeeeee 888‌

References

Meeeeee Meeeeeeeeee

• 8.Meeeee-Meee, (8888) M 88-8, 888.