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3.4.2.4 Method 4: From Alkynes and Copper(I) Salts and Complexes

DOI: 10.1055/sos-SD-003-00274

Heaney, H.; Christie, S.Science of Synthesis, (20043390.

In addition to the methods carried out in aqueous solution that are discussed in Section 3.4.2.1, alkynylcopper(I) derivatives can be prepared in nonaqueous solvents or, alternatively, they can be generated and used in situ without isolation. As an example of the first option, the copper(I) derivative involved in the reaction shown in Scheme 115 was isolated in 92% yield in dimethyl sulfoxide by the interaction of copper(I) iodide with the tetrahydropyranyl ether derived from 1-acetoxybut-3-yn-2-ol, before it was used in the reaction.[‌552‌]

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