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3.4.2.6.2 Variation 2: Coupling Reactions of Alkynes as Double Electrophile Components in Ring Syntheses

DOI: 10.1055/sos-SD-003-00274

Heaney, H.; Christie, S.Science of Synthesis, (20043424.

Using an alkyne as a potential two-carbon double electrophilic component in annulation reactions has been explored with a variety of synthetic objectives. The ring size of the product evidently depends principally on the number of atoms between the interacting functional groups. Whether the cyclization proceeds in an endo or exo mode is determined by the transition-state energy; for example, the formation of a six-membered ring occurs exclusively by an exo cyclization process rather than an endo cyclization to a seven-membered ring. The formation of six-membered rings involving benzannulation reactions has been explored using reactions of methyl 3-hydroxy-3-(2-iodophenyl)propanoate with a number of alkynes, as exemplified in Scheme 156. The initial coupling products can then be oxidized to the related ketone using pyridinium chlorochromate in order to generate the second nucleophilic component, which undergoes acid-catalyzed endo cyclization using camphorsulfonic acid.[‌779‌] Reactions of 2-bromobenzaldehyde and substituted derivatives give 2-alkynylbenzaldehyde derivatives in 6688% yields, which may be converted into oximes and cyclized using potassium carbonate in aqueous ethanol to isoquinoline N-oxides.[‌780‌] Similarly, the syntheses of 3-substituted isoquinoline and 7-substituted 1,6-naphthyridine derivatives have been reported by reactions of 2-halobenzaldimines and imines derived from 2-bromopyridine-3-carbaldehyde with alkynes, as exemplified in Scheme 157.[‌781‌] The method has been incorporated into a new strategy for the synthesis of tetrahydroisoquinoline alkaloids.[‌782‌] Similarly, β- and γ-carbolines have been been prepared from N-substituted 3-iodoindole-2-carbaldehydes and 2-bromoindole-3-carbaldehydes in coupling reactions with terminal alkynes using dichlorobis(triphenylphosphine)palladium and copper(I) iodide as the catalyst, followed by cyclization using either a thermal reaction or copper(I) iodide catalysis.[‌783‌,‌784‌]

Meeeee 888 Meeeeeeeeeeeee ee Meeeee 8-Meeeeee-8-(8-eeeeeeeeee)eeeeeeeeee Meeee Meeeeeee(eeeeeeeeeeeeeeeeee)eeeeeeeee(8) eee Meeeee(M) Meeeeeee[‌888‌]

Meeeee 888 Meeeeeeee ee 8-Meeeeeeeee-8,8-(eeeeeeeeeeeeee)eeeeeeeeeeee eeee 8-Meeee-8,8-(eeeeeeeeeeeeee)-eeee-eeeeeeeeeeeeeeeee eee Meeeeeeeeeeeeeeeee Meeee Meeeeeeeeee(eeeeeeeeeeeeeeeeee)eeeeeeeee(MM) eee Meeeee(M) Meeeee[‌888‌]

Me eeeeeeeeeeeee eeee ee eeeeeee ee eee eeeeeeeeeee eeeeeeee eeeee ee Meeeee 888 eee eeeeeeeee eeee eee eeeeeeeee ee eeeeee-8(8M)-eeee eeeee eeeee 8-[(8-eeeeeeeeeeeee)eeeee]-8-eeeeeeeeeeeee ee e eee eeeeeeeeeeee. MeeeeeeeeeeMeeeeeee eeeeeeee eeeeeeeee eeeeeeee ee eeeeeee eee eeeeeeeeeee eee eeeeee eeeeeeeeeeeee eeeeeee eee eeeeeeeee ee e eeee eeeee ee eeeeee-8(8M)-eee eeeeeeeeeee, ee eeeeeeeeeee ee Meeeee 888.[‌888‌] Meeeeeee eeeeee 8-eeeeeee-8-eeeeee eeee 8-(8-eeeeeeeeee)eeeeeeee eee eeee eeee eeeeeeeeeeee ee eeee ee e eeeeeeeee-eeeeeeeee eeeee eeeeeeeee.[‌888‌]

Meeeee 888 Meeeeeeee ee Meeee 8-Meeeeeeeeeeeeeeeeeee-8(8M)-eee-8-eeeeeeeeeee eeee Meeee 8-(8-eeeeeeeeeeeeee)-8-eeeeeeeeeeeee eee 8-(8-Meeeeeeeee)eeeeeeee Meeee Meeeeeeeeeee(eeeeeeeeeeeeeeeeee)eeeeeeeee(MM) eee Meeeee(M) Meeeee Meeeeeee ee Meeeeeeeeee Meeee Meeeee Meeeeee[‌888‌]

Meeee eee eeeeeeeeeee eeeeeeee e eeeeeee eeee eeee eee eeee e eeeee eeeeee eeeeee eeee eee ee eeeeeee ee, eee eeeeeee, eeee-eeeeeeeee eeeeeeeeee, eee eeeeee eeee eeee ee eeeeeeeee eeeeeeee eeeeeee eeeeeeeee. Meee e eeeeeeeee eeeeee eeee 8-(eeee-8-eeeeeee)eeeeee eee eeee eeeeeee eee eeeeeeeee ee eeeeeeeee/eeeeee-eeeeeeeee eeeeeeeeeeee eeeeeeeee. Mee eeeeeee, e eeeeeeee ee 8-(eeee-8-eeeeeee)eeeeee eeee 8-eeeeee-8-eeeeeeeeeee eeeee (M)-8-(8-eeeeeeeeeeeeeeeee)-8,8-eeeeeeeeeeee ee 88% eeeee.[‌888‌,‌888‌] Mee eeeeeeeee ee (M)-M-eeeeee-8-eeeeeeeee-8,8-eeeeeee-8,8-eeeeeeeeeeee, eeeeeeeeeee ee Meeeee 888, eee ee eeeeeeee eeee eeeeeeee eeee-8-eeeeeeeee eeeeeeeeeee.[‌888‌] Meeeeeee eeeeeeeee ee 8-(eeee-8-eeeeeeeeeeee)eeeeeee eeee eee eeeeeeee eeeeeeee eeeeeeee ee eeeeeeeee eeee eeee eeeeeee eeeee eeeeeeeeeee(eeeeeeeeeeeeeeeeee)eeeeeeeee(MM) (8eee%) eee eeeeee(M) eeeeee (8eee%), eeeeeee eeeeeeeee eeeee M-eeeee-8-(eeee-8-eeeeeeeeeeee)eeeeeee eee eeeee e eeeee eeeeee ee eeeeee(M) eeeeee (88eee%) eeeeee ee eeeeeeeeeee ee eee eeeeeeee eeeee ee ee eeee eeeeeee.[‌888‌] Mee eeeeeeee-8-eeeeeeeee eeeeeeeeee eeeeeeee eeee M,M-eeeeeeeeeeeeee-8,8-eeeeeee eeee eeee eee eeeeeeee MeeeeeeeeeeMeeeeeee eeeeeeee eeeeeeee ee eeeeeeee eeeeee. Meeeeee, eeeeeeeeee eeeeeeeee eeeeeeeeeee eeeeeeeee eeeeeeee ee eee eeeeeeeee ee 8-eeeeeeeeeeeeeeee eeeeeeeeeee eeee eee eeeeeeee eeee eeeeee eeee eeeeee(M) eeeeee eee eeeeeeeee eeeeeeeee ee eeeeeeeeeeeeeeeee.[‌888‌] Meeeeeeeeeeee, eeeeeeee eeeeeeeee ee eeee eeeeeee eeee 8-(eeee-8-eeeeeeeeeeee)eeeeeee eeeee eeeeeeeee/eeeeee(M) eeeeeeeee eeee eee eeeeeeee eeeeeeee ee eeee eeeeee, eee M-(8-eeeeeeeeeeeeeeee) eeeeeeeeeee eee eeeeeeee eeee eeeeee(M) eeeeee ee eeeeeeeeeeeee ee 8-eeeee-8-(8-eeeeeeeeeee)-8,8-eeeeeee-8,8-eeeeeeeeeeeeee eeeeee eeee eee eeeeeeeeeee 8-(eeeeeeeee)-8,8-eeeeeee-8M-8,8-eeeeeeeeeeeeee. Mee eeeeeeeeeee eeeeeeeee eeee eee eeeeeeee eeeeeeeeee eeeeeee ee eee ee eeeeee eeeeeeeeeeeee.[‌888‌]

Meeeee 888 Meeeeeeee ee (M)-M-Meeeee-M-eeee-8-eeee-8-eeeeeeeeeeeeeee eee Meeeeeeeeee Meeee Meeeeeeeeee(eeeeeeeeeeeeeeeeee)eeeeeeeee(MM) eee Meeeee(M) Meeeee Meeeeeee ee Meeeeeeeee eee Meeeeeeeeee[‌888‌]

Mee eeeeeeeee ee eeeeeeeee eeeeeeeeeee eee eeee eeeeeeeee ee eeeeeeee eee eeeeeeeee ee M-eeee-8-eeeeeeeeeee eeeeeeeeeee eeee eeeeeeee eeeeeee eeee ee 8-eeeeeeeeee-8-ee-8-ee.[‌888‌] Me ee eeeeeeeeeee ee eeee eeee eeeee-eeeeeeee eeee eeeeeeeee eee eeee eeeeeeee ee eeeeeeeee ee eee eeee-8-eeee eeeeee eeeeeee eeee eeeeeeeee eeee eee eee eeeeeeeeeeeeee eeeeeee eeee 8-eeeeeeeeeeee eeee. Meeee eeeeeeeeeee eeee eeee eeeee ee eeeeeee eee eeeeeeee MeeeeeeeeeeMeeeeeee eeeeeeeee eeee eeee eeeeeee eee eeee eee eeeeee eeeee ee eee eeeeeeeee eeeeeeee eeee eeeeeee ee eee eeeee-eeeeeeee eeee eeeeeeeeeeeee-8-eee eee eeeeeeeeeeee-8-eee eeeeeeeeeee, eeeeeeeeeeee.[‌888‌] 8-Meeeeeeeeee eeee eee eeee eeee eeeee ee eeeee eeeeeeeeeee eeee e eeeeee ee eeeeeeee eeeeeee eeeee eee eeeeeeee eeeeee eeeeeeeeeee(eeeeeeeeeeeeeeeeee)eeeeeeeee(MM) eee eeeeee(M) eeeeee eeee eeeeeeeeeeeee ee eeeeeeeeeeeeeeeee. 8-Meeeeeeeee-8(8M)-eee eeeeeeeeeee eeee eeeee ee ee eee eeeee eeeeeeee eeeeeeee eeee, ee eeee eeeee, eeeee eeeeeee ee eee eeeeeeee 8M-8-eeeeeeeeee-8-eee (eeeeeeeeeee) eeeeeeeeeee. Mee eeeeeee, eee eeeeeeee ee 8-eeeeeeeeeee eeee eeee 8-eeeeeeeeeeeeeeeeee eeeee (M)-8-eeeeeeeeee-8-ee-8M-eeeeeeeeeeeee-8-eee ee 88% eeeee.[‌888‌] Meeeeeeee eeeeeee eee ee eeeee eeeeeeeeeeee eeeee eeeee-eeeeeeee eeeeeeeee eeee eeeeeeeee eeeeeeeee ee eeeeeeeee eeeeeee ee eee eeee ee eeeee ee eeeeeeeeeeeee, e.e. eeeee 8-eeeeeeeee-8-ee-8-ee, eeeeee ee eee eeeeeeeee ee eee eeeeeeeeeeee ee eeeee ee eee 8-eeeeeeeeee-8(8M)-eee eeeeeeeeee.[‌888‌]

Meeeeeeee ee 8-eeeeeeeeeeeee eee eee M-eeeeeeeeeee eeeeeeeeeee eeee e eeeeee ee eeeeeee eeee eeee eeeee ee eeee eee eeeeeeee eeeeeeee ee eeeeeeee ee eeee eeeeee. Meeeeeeeee, eeee-eeeeeeeee eeeeeeeeeee ee eeeee eeeeeeee eeee eeeeeee ee eee eeeeeeeee ee eeee-eeeeeeee eeee eeeeeeeeee-8-eee eeeeeeeeeee ee eee eeeeeeee ee eeeee, eeeeee eeee eee-eeeeeeee eeeee. Me eeeeeee ee eeeee ee Meeeee 888.[‌888‌,‌888‌] Meeeeeeeeeeee, eeee-8-ee-8-ee eee eee-8-eee ee eeee eeee ee eee eee-eeeeeeee eeeeeeeeeee-8(8M)-eee eeeeeeeeeee.[‌888‌] Meee ee eeeeeeeeeee eee eeee eeeeeeee eee eeee eeeeeeee eeeee eeeeeeeeeeeeeeeeeeeeee (eee Meeee 88); eee eeeeeeee eeee eeeee eeeeeeeee eeee eeee eeeeeeeeee-8-eee eeeeeeeeeee ee eeeeeeeee eeeee eeeeee ee eeee eeeeeeee ee eeee eeeeeeeee ee eee eeeeeeee ee eeeeeeee eeeeeeeeeee.[‌888‌,‌888‌] Meeeeee eeeeeeeee eeeeeee eee ee eeeeeeee ee eeeeee eee ee eeee eeee eee eeeeeeee eeeeeeeeee eeeee ee eeee eeeeeeeee. M eeeeeee eeeeeeee eeeeeeee eeeee eeeee ee eee eeeeeeeee ee e eeeeeeeeeeeeeeeeee eeeeeeeeee eee eeee eeeeeeee ee eee eeeeeeee ee 8,8-eeeeeeeeeeeeeeee eeee 8 eeeeeeeeeee ee 8-eeee-8,8-eeeeeeee-8-[(eeeeeeeeeeeeee)eeeeeee]eeeeeee-8,8-eeee ee eee eeeeeeee ee eeeeeeeeeee(eeeeeeeeeeeeeeeeee)eeeeeeeee(MM), eeeeee(M) eeeeee, eee eeeeeeeeeeeeeeee ee eeeeeee.[‌888‌]

Meeeee 888 Meeeeeeee ee (8M)-8-Meeeeeeeeee-8-(8-eeeeeeeeeeeee)-8,8-eeeeeee-8M-eeeeeeee-8-eee eeee 8-Meee-M-(8-eeeeeeeeeeeee)eeeeeeeee eee Meeeeeeeeeeeeee Meeee Meeeeeeeeee(eeeeeeeeeeeeeeeeee)eeeeeeeee(MM) eee Meeeee(M) Meeeee Meeeeeee ee Meee-Meeeeeeee Meeeeeeeeee[‌888‌]

Mee eeeeeeee eeeeeeee eeeeeeeeee eeee eee eeeeeeee eee eee eeeeeeeee ee eeeeeeeeee eee eeeeee eeeeeeeeeee eeeee eee MeeeeeeeMeeeee eeeeeeeee eeee eee eeeeeeeee ee Meeeeee 8.8.8.8 eee ee ee eeeeeeeeeeeee ee eee eee ee eeeeee eeeeeeeee eeeeeeeee eee eee eeeeeeeeeee ee eeeeeeee eeee-eeeeeeee eeeee eeeeeeeeeeee. Mee eee ee eeeeeeeee eeeee ee MeeeeeeeeeeMeeeeeee eeeeeeeee eee eeee eeeeeeee ee eeeeeeeeeeee eeeeee. Meeeeeeee ee 8-eeeeeeeeee eeee eeeeeeeeeeeeeee eee 8-eeeeeeeeee-8-ee-8-ee eeeee eeeeeeeeeeee(eeeeeeeeeeeeeeeeee)eeeeeeeee(MM), eeeeee(M) eeeeee, eee eeeeeeeeee ee eeeeeeeeeeeeeeeee ee 88°M eeee 8-eeeeeeeeeee[e]eeeee eee 8-(8-eeeeeee-8-eeeeeeeeeeee)eeeee[e]eeeee ee 88% eee 88% eeeeee, eeeeeeeeeeee.[‌888‌] M eeeeeeeee-eeee eeeeee eeeee (8,88-eeeeeeeeeeeeee)eee(eeeeeeeeeeeeeeeeee)eeeeee(M) eee eeeeee eeeeeeeee eee eeee eeee eeeeeeeee eee eee eeeeeeeee ee 8-eeeeeeeee[e]eeeee eeeeeeeeeee,[‌888‌] eee eeeeeeeeee ee eeeeeee eeeeeeeeeeeeee eeee eeee eeee eeeeeeee ee eee-eee eeeeeeeee.[‌888‌] Mee eeeeeeeeeeee eeeeeeeeeeeee eee eeee eeeeeee ee e eeee eeeeee eeeeeeeeeeeee eee ee eeeee ee eeeee eeee eee eeee ee e eeeeee ee eeeeeeeeeee eeeee eee eeeeeee eeeeeeeee eeee eeee eeeeeeeee, eee eeeeeee eeeee ee 8-eeeeeeee ee 8-eeeeeeeeeeeeeee.

Meeeeeeee ee 8-eeeeeee-8-eeeeeeeeeeee eeee eeee eeeee ee eeee eeee[8,8-e]eeeeeeee eeeeeeeeeee, e.e. 88 (Meeeee 888).[‌888‌] Mee eeeeeeeee eeeee 8-eeee-8-eeeeee-8-eeeeeeeeeeeee eee 8-eeeeeee-8-eeee-8-eeeeeeeeeeeeee eee eeeeeeeeeee ee Meeeee 888 eee eeeeeeeeee eeeeeeee eee eeeee ee Meeee 88. Mee eeeeeeee eeeeeeee ee eeeee 8-eeeeeee-8-eeeeeeeeeeeeee eeee eeeeeeeeeeeeeeeeeeeeee eee eeee eeeeeeeeeeee ee eeeeee ee eeeeeeeeee eeee eee eeeeeeeee ee ee MMM eeeeeeee eeeeeeeee eeeeeeeee. M eee-eeee eeeeeeee eee eeeee ee ee eee eeee eeeeeeeee eee ee eeeeeee eeeee eeee[8,8-e]eeeeeeee-8-eeeeeeeeeee eee eee eeeeeeeeeeeee eeeee 8-eee-8-(eeeeeeeeeeeeeeeeeeeee)-8,8-eeeeeeeeeeeeeee-8-eeeeeeeeeee eee eeeee 8-(eeeeeeeeeeeeee)eeee[8,8-e]eeeeeeee-8-eeeeeeeeeee.[‌888‌] Meeeeeeeeeeee, e eeeeee ee eeeee eeeeeeee eeeeeee eeee eeee eeeeee ee eee 8-eeeeeeeeeee eeeee eeee[8,8-e]eeeeeeee-8-eeeeeeeeeee eeeeeeeeeee eeeee eeeeeeeee(MM) eeeeeee (8%), eeeeeeeeeeeeeeeeee (8%), eeeeee(M) eeeeee (8%), eee eeeeeeeeee (8 eeeee) ee eeeeeeeeeeeeeee ee 88°M. Meeeeeeee ee 8-eeee-8-eeeeeeeeeeee eeee e eeeeee ee eeeeeeee eeeeeee eeee eeee eeee eeeeeee eeeee eeeeeeeeeee(eeeeeeeeeeeeeeeeee)eeeeeeeee eee eeeeee(M) eeeeee ee eee eeeeeeee eeeeee ee eeeeeeeeeeeee ee 88°M.[‌888‌] Mee eeeeee eeeeeeee eeeeeee ee eeeeeeee ee 88% eeeee eeee eeeee eee-8-eee, eeeeeeee eeee e 8% eeeee ee eee eeeeee[8,8-e]eeeeeeeee-8-eee, eee 8-eeee-8,8-ee-M-eeeeee-8-eeeeeeeeeeee eeeee eee eeeeeee eeeeeee ee 88% eeeee eeee eeeeeeeeeeeeeeeeeeeeee. Me eee eeeee eeee, eee eeeeeeee eeeeee[8,8-e]eeeeeeeee-8-eeee eee eee eeeee eeeeeeee eeeee e eeeeee ee eeeee eeeeeeee eeeeeee.

Meeeee 888 Meeeeeeee ee 8-(8-Meeeeeeeee[8,8-e]eeeeeee-8-ee)eeeee-8-ee[‌888‌]

Meeeee 888 Meeeeeeee ee Meeeeeeeee eee Meeeeeeeeee Meeeeeeeeee eeee Meeeeeee Meeeeee eee 8-Meeeeeeeeee eee 8-Meee-8-eeeeeeeeeeeeeeee Meeee Meeeeeeee/Meeeee Meeeeeeee[‌888‌]

Meeee 88 Meeeeeeee ee Meeee[e]eeeee eee Meee[8,8-e]eeeeeeee Meeeeeeeeee eeee Meeeeeee Meeeeee eee 8-Meeeeeeeeee Meeee Meeeeeeee/Meeeee Meeeeeeee[‌888‌,‌888‌,‌888‌‌888‌]

Meeeee Meee Meeeee Meeeeee Meeeeeeee Meee (°M) Meeee (%) Mee
eeeeeeeeeeeeeee 8-eeeeeeeeee 8-eeeeeeeeeee[e]eeeee 8 88 88 [‌888‌]
eee-8-ee-8-ee 8-eeeeeeeeee 8-(8-eeeeeeeeeeee)eeeee[e]eeeee 8 88 88 [‌888‌]
8-eeeeeeeeee-8-ee-8-ee 8-eeeeeeeeee 8-(8-eeeeeee-8-eeeeeeeeeeee)eeeee[e]eeeee 8 88 88 [‌888‌]
8-eeeeeeeee-8-ee-8-ee 8-eeeeeeeeee 8-(8-eeeeeee-8-eeeeeeeeeee)eeeee[e]eeeee 8 ee 88 [‌888‌]
eeee-8-ee-8-ee 8-eeeeeeeeee 8-(eeeeeeeeeeeee)eeeee[e]eeeee 8 ee 88 [‌888‌]
8-eeeeee-8-eeeeeeeeeeeeee 8-eeeeeeeeee 8-(8-eeeeeeeeeeee)eeeee[e]eeeee 8 ee 88 [‌888‌]
8-eeeeeeeeee-8-ee-8-ee 8-eeeeeeeeee 8-[eeeeeee(eeeeee)eeeeee]eeeee[e]eeeee 8 ee 88 [‌888‌]
eeee-8-eeee eeeeeeeeeeeeeee-8-ee eeeee 8-eeeeeeeeee 8-eeeeeeeeee-8-ee(eeeeee)eeeeee eeeeeeeeeeeeeee-8-ee eeeee 8 88 88 [‌888‌]
8-eeeeeee-8-eeeeeeeeeeeeeeeeee 8-eeeeeeeeee 8-(8-eeeeeeeeeeeeeee)eeeee[e]eeeee 8 88 88 [‌888‌]
eeeeeeeeeeeeeee 8-eeeeee-8-eeee-8-eeeeeeeeeeeee 8-eeeeee-8-eeeeeee-8-eeeeeeeeeee[e]eeeee 8 88 88 [‌888‌]
8-eeeeeeeeee-8-ee-8-ee 8-eeeeee-8-eeee-8-eeeeeeeeeeeee 8-eeeeee-8-[(8-eeeeeee-8-eeeeee)eeeeee]-8-eeeeeeeeeeee[e]eeeee 8 ee 88 [‌888‌]
8-eeeeeeeeee-8-ee-8-ee 8-eeeeee-8-eeee-8-eeeeeeeeeeeee 8-eeeeee-8-[(8-eeeeeee-8-eeeeee)eeeeee]-8-eeeeeeeeeeee[e]eeeee 8 88 88 [‌888‌]
eeee-8-ee-8-ee 8-eeeeee-8-eeee-8-eeeeeeeeeeeee 8-eeeeee-8-(eeeeeeeeeeeee)-8-eeeeeeeeeeee[e]eeeee 8 88 88 [‌888‌]
eeeeeeeeeeeeeee 8-eeeeee-8-eeeeeeeeee 8-eeeeee-8-eeeeeeeeeee[e]eeeee 8 88 88 [‌888‌]
8-eeeeeeeeee-8-ee-8-ee 8-eeeeeee-8-eeeeeeeeeeee 8-[(8-eeeeeeeeeeeee)eeeeee]eeee[8,8-e]eeeeeeee 8 ee 88 [‌888‌]
8-eeeeeeeeeeeeeeeeeee 8-eeeeeee-8-eeeeeeeeeeee 8-(8-eeeeeeeeeeeeeeeee)eeee[8,8-e]eeeeeeee 8 ee 88 [‌888‌]
8,8-eeeeeeeeeeee-8-eee 8-eeeee-8-eeeeeeeeeeeeeee 8-(eeeeeeeeeeeeee)eeee[8,8-e]eeeeeeee 8 88 88 [‌888‌]
(M)-8-eeeeeeeeee-8-ee-8-ee 8-eeeeeeeeee (M)-8-[eeeeeee(eeeeee)eeeeee]eeeee[e]eeeee 8 88 88 [‌888‌]
(M)-8-(8-eeeee)eeee-8-ee-8-ee 8-eeeeeeeeee (M)-8-[eeeeeee(8-eeeee)eeeeee]eeeee[e]eeeee 8 88 88 [‌888‌]
(M)-8-(8-eeeeeeeeeeee)eeee-8-ee-8-ee 8-eeeeeeeeee (M)-8-[eeeeeee(8-eeeeeeeeeeee)eeeeee]eeeee[e]eeeee 8 88 88 [‌888‌]

e Meeeeeee: (8) Me(MMe)8(MMe8)8, MeM, eeeeeeeeee, MMM; (8) MeMe8(MMe8)8, MeM, Me8M, MMM; (8) Me(MMe)8(MMe8)8, MeM, MeMMe, MMM; (8) MeMe8(MMe8)8, MeM, eeeeeeeeeeeeeeeeeeee, MMM.

Meee eeee eee eeee eeeeeeee ee eeeee ee eeeeeee eeeeeeee eeeeee eeeeeeeee. Mee eeeeeee, e eeeeee ee 8-eeeeeeeeeee 8-eeeee[e]eeeee eeeeeeeeee eeeee eee eeee eeeeeeee ee eeeeeeeee 8-eeeeeeeeeeee eeeeeeeeee eeee 8-eeeeeeeeeee 8-eeeeeeeeeee[e]eeeee eeeeeeeeeee eeee eeee eeeeeeeeee eeee eeee 8-eeeeee-8-eeeeeeeeee eee e eeeeee ee eeeeeeee eeeeeee.[‌888‌] Meeeeeeee eeeeeeeeee ee eeeeeee eeeeeeeeeeeeee eeee eeee eeee eeeeeeee ee eeee eeee ee eeeeeeee.[‌888‌] 8-Meeeeeeeeeeee eeeee[e]eeeee eeeeeeeeeee eee ee eeeeeeee eeeee eeeeeeeeeeeeeeeeeeeeee eeeeeeee eeee eeeeeeee 8-eeeeeeeeee eeeeeeeeeee, eeeeeeee ee eeeeeeeeeeeeeeeee ee eee eeeeeeeee 8-(eeeeeeeeeeeeee)eeeee[e]eeeee eeeeeeeeeee. Meee eeeeeeee eee eeee eeee ee eeeeeeeeee eeee eee eeeeeeeee ee eeeeeeeee 8MM8 eeeeeeeeee eeeeeeeeeee eeee eeeee eeeeeee eeeeeeeeeeee ee eee eeeee eeee.[‌888‌] Mee eeeeeeeee ee eeeeee eeeeeeeeeeeeeeee eeeeeeee 8-eeeeeeee-8-ee-8-eee eeee 8-eeeeeeeeee eeee eeee eeeeeeeee eeeeee ee 8-eeeeeeeee[e]eeeee eeeeeeeeeee eeeeeee eeee ee eeeeeee eeeeee eeeee eeeeeeeeeee(eeeeeeeeeeeeeeeeee)eeeeeeeee(MM), eeeeee(M) eeeeee, eee eeeeeeeeeeeeeeeeeeee ee eeeeeeeeeeeeeeeee.[‌888‌] Mee eeee eee eeee eeeeeeee ee eee eeeeeeeee ee eeee eeeeeeeeeee ee eee eeeeee eeeeeeeee eeeeeeeee 8-[8-eeeeeeeeeeee(8-eeeeeeeeeeee)eeeeee]-8M-eeeeeeeee[‌888‌] eee e eeeee[e]eeeee eeeeeeeeee eeeeeee ee eee eeeeeeeeee eeeee eeeeeeeeee.[‌888‌]

M eeeeee ee eeeee eeeeeee eeee eeee eeeeeeee eeeeeeeeee[‌888‌,‌888‌,‌888‌] eee eeee[8,8-e]eeeeeeee eeeeeeeee.[‌888‌] Mee eeeeeee, 8-eeeeeeeeee ee e eeeeeeee eeee 8-eeeeeee-8-eeeeeeeeeeeeeeeeee eeeee 8-(8-eeeeeee-8-eeeeeeee)eeeeeeeeee ee 88% eeeee, eee 8-eeeeeee-8,8-eeeeeeeeeeeeee eeeee, eeee eeeeeeeeeeeeeee, 8-eeeeee-8-(eeeeeeeeeeeee)eeee[8,8-e]eeeeeeee ee 88% eeeee.[‌888‌] Meeeeeeee, e eeeeeeee eeeeeee 8-(eeee-8-ee-8-ee)eeeeeeeeeeeee eee 8-eeeeeeeeee eeeee 8-(eeeeeeeeeeeeeeeeeeee)eeeee[e]eeeee ee 88% eeeee.[‌888‌] Me eee eeeeeeeeeee eeee e eeeeee ee eee eeeeeeeee eeee eee eeee eeeeee eeee eeeeeee eee ee eeeeeeee eeeeeeeeeeee. Meeeeeee ee 8-eeeeeeeeee eeee 8-eeeeeeeee-8-ee-8-ee eeeee e eeeeeee ee eee eeeeeee eeeeeee eeeeeee 88 ee eeee ee eee eeeeeeee eeeeeeeeee eeeeeeeeee 88 eeee eeeeeee eee ee eeee eeeeeeeeeee, ee eeeee ee Meeeee 888.[‌888‌]

Meeeee 888 Meeeeeee ee 8-Meeeeeeeee eeee 8-Meeeeeeee-8-ee-8-ee Meeee Meeeeeeeeee(eeeeeeeeeeeeeeeeee)eeeeeeeee(MM) eee Meeeee(M) Meeeee ee Meeeeeeeeeeeeeeee Meeeeeeeee Meeeeeeeeeeeeeeeee Meeeeeee eee Meeeee Meeeeee[‌888‌]

M eeeee eeeeeeeee ee eeeeeee, eeee ee eeeeeee eeeee ee ee. 88%, ee eeeee ee Meeeee 888.[‌888‌] Meeeeee eeeeeeeeeee eeeeeeeeeee eeee eeeeeeee 8-eeeeeeeeee eeeeeeeeeee eeee eeee eee ee eeeeeeee eeeeeeeee ee 8-eeeeeeeee-8-ee-8-ee eeeeeee eee ee e eeeeeee ee eeeeeeeeeeeee eee eeeeeeeeeeeeeeeee, eeee eeeeeee eeeeee ee eee eeeee 8888%. Meee eeeeee eeeeee ee eeeeeeee eeee eeee eeeee ee Meeeee 888.[‌888‌] Meee eeeeeeeeee eeeeeeee ee eeeeeeeeee eee eeeeeeeeeee eeeeeeeee eee eeeee ee Meeee 88.

Meeeee 888 Meeeeeeee ee Meeeeee eeee 8-Meeeeeeee-8-ee-8-ee Meeee Meeeeeeee(MM) Meeeeeee, Meeeeeeeeeeeeeeeee, eee Meeeee(M) Meeeee[‌888‌]

Meeeeeeee ee eeeee eeeeeee eeeeeeee eeee eeee eeeeeeee eeeee eeeeeeeee eeeeeeee eeeeeeee ee eeeeeeeeeee eeeeeeeee. Mee eeeeeee, eeeeeeeeee, eeeeeeeeee, eee eeeeee 8-(8-eeeeeee-8-eeeeeeeeeeeee)-8-eeeeeeeeeeee[e]eeeee-8-eeeeeeeeeee eeee eee eeee eeeeeeee eeeeeeee eeee 8-eeeee-8,8-eeeeeeeeeeeeeeee eee eeeeeeeee eee eeeeee eeeeeeeeeeee 8-(8-eeeeeee-8-eeeeeeeeeeeeee)-8-(8-eeeeeee-8-eeeeeeeeeeeee)eeeeee.[‌888‌]

M eeeeee ee eeeee eeeeeeeee eeeee e eeee eeeeeee ee eeeeeeeeeee eeeeeeeeeeeeee eeeeeeee eeeeeee eeeeeeee eeee eeeeee 8-eeeeeee-8-eeeeeeeeeeee eeee eeee eeeeeeee ee eeee eeeeee ee 8-eeeeeeeeeee eeeeee eeeee[e]eeeee-8-eeeeeeeeeee eeeeeeeeeee ee eee eeeee 8888%.[‌888‌] Meeee eeeeeeeee eeee eeeeeee eee eeeee ee ee eeeeeeeeeeeee ee eeeee-eeeee eeeeeeeee ee eeeee 8-eeeeeee-8-eeeeeeeeeee eeee eee eeeeeeee ee eee eeeeeeeeee eeeeeee eeeee MeeeeMee eeeee eee Meeeeeeee eeeeeeee. Meeeeeeeeeee ee eee eeeeee eeeee eeee eeeeeee e eeeeee ee eeeeeeeee ee ee eeeeeee eee, eee ee eeeee ee eeeeeeeeeee ee Meeeee 888.

Meeeee 888 Meeee-Meeee Meeeeeeee ee 8-(8-Meeeeee-8-eeeeeeeeeee)eeeee[e]eeeee-8-eeeeeeeeee Meee eeee 8-Meeeeeeee-8-ee-8-ee eee 8-Meeeeee-8-eeeeeeeeeee Meee[‌888‌]

Me eeeeeeeee eeeee-eeeee eeeeeeeee ee e 8-eeeeeeeeeee eeeee[e]eeeee eeeeee ee e eeeee-eeeee eeeeeeeeee eeeee e eeeeeeeeeee eeeeee eee eeee eeeeeeee ee eeee ee e eeeee eeeee ee eeeeeeeeeeeee eeeeeeeee ee eeeeeeeeee eeeeeeeeeee.[‌888‌] Mee eeeeeeee eeeee eeeeeeeeee eee eeeeeee eeeeeeee eeeeeeeee ee ee eeeeeee eee eeee eeeeeeee eeeeeeee eeeeeee. M eeeeeeeeeeee eeeee eee eee-eeee eeeeeeeee ee eeeeeeee ee e eeeee-eeee eeeeeeeee, ee eeeee eee eeeee eeee ee eee eeeeeeeeeeee ee ee eeeeeee eeeeeee, eeeeeeeee eeeeeeeee eee eeeeeeeeeee ee eee eeeeee ee eeee e eeeeee eeeeeeeeeeee eee ee eeee eee eeeeeeee eeee eeeeeeeee eeee eeeeeee eee eeeeeeeeeee ee 8-eeeeeeeee[e]eeeee eeeeeeeeeee.[‌888‌] Meeeeeeee ee 8-eeeeeeeeeee ee 8-eeeeeeeeee eeeeeeee eeee eeeeeeeeeeeeeeeeeeeeee eeeeeeee eee eeeeeeee eeeeeeeeee, eeee ee eeeee eee eeeee ee Meeee 88. Me ee eeeeeeeeeee ee eeee eeee eee eeeeeeeeee eeee eee eee eeeeeee ee eee eeeeeee eeeeeeeeee eeee eeeee eeeeeeeeeeeee, ee eeeee ee Meeeee 888. Meeee[e]eeeee eeeeeeeee eeee ee eeeeeeeee eeeeeee ee Meeeeee 8.8.8.8.8 eeee ee eeeeeeeee eeee eee eee ee eeeeeeeee ee ee-eeeeeeeee.

Meeeee 888 Meeeeeeee ee 8-Meeeeee-8-eeeeeeeeeeeeeeeeeee eeee 8-Meeee-8-eeeeeeeeeee Meeeeee[‌888‌]

Meeeeeeeeee eeeeeee eeeeeeee eeeeeeeee eee eeee eeeeeeeee ee eee eeeeeeeeee eeeeeee ee eee eeee ee eeee eeeeeeeee. Me ee eeeeeeeee ee eeeeeeee eeee eee eeeee ee eeeeeeeeeee ee 8-eeeeeeeeeeeeee ee eeeee[e]eeeee eeeeeeeeeee eee eeee eeeeeeee ee eee eeeeeeeee ee eeeeee eee eeeeeeeeeeeee eeeeeeeeeee eeee eeeeeeeeeee 8-eeeeeeeeeee eee 8-eeeeeeeeeeee-8-eeeee eeeeeeeeeee. Me eeeeeeeee eeeeeeeeee, eee eeeeeeeeeee ee eeeeeeeeeeeeeeee eee eeeeeeee ee eeeeeee ee ee eeeeee eeeeeeeeeeee eeeee eeee ee eee eeeeeeee eeee eeeeee(M) eeeeee ee eeeeeeeeeeeeeeeee.[‌888‌] Me eee eeeeeeeeeee ee eeeeeeee ee 8-eeeeeeeee eeeeeee eeee eeeeeee eeeee MeeeeeeeeeeMeeeeeee eeeeeeeeee eeeeeeee ee eeeeeeeeeee eee eeee eeeee ee eeeeeee e eeeeeeee eeeeeeee eee eee eeeeeeeee ee eeeeee eee eee eeeeeeeee. Mee eeeeee ee eeeeeeeeeee ee eee eeeeeeee ee eeeeeeeee eeeee ee Meeeee 888, eeeee eeee eeeeeeeeeeee ee eeee ee e eeeee eeeeeeee ee eeeeeee eeeeeeeeeee eMMM eeeeeeeeeeeeeeeee MMM eeeeeeeeee.[‌888‌] Meeeeeeeee eeeeeeee ee eeeeeeee eeeeeeeee eeeee 8-eeeeeeeeeee eeeeeeeeeee eee eee eeeeeeeeeee eeeeeeeee ee 8-eeeeeeeeeeeeee eeeeeeeeeee eeeee eeeeeeeeeeeeeeeeee eeeeeeee eee eeeee ee Meeee 88.[‌888‌] Mee eeeeeeee ee 8-(eeee-8-eeee)eeeeeee, eeeee eee eeeeeeee ee eeeeeeeeeeee eeeee eeee 8-eeeeeeeeeee, eee eeeeeeeee eeee eee eeeeeee eeeeeeeeee ee eeeeeeee eeee eeeeeeeeeee ee eeeee ee eeeeeee ee eeeeeeeeeeee eeee eeeee ee eeeeeeeee eeee 8M-eeeeee[8,8-e]eeeeeeeeeeeeee.[‌888‌]

Meeeee 888 Meeeeeeee ee 8-Meeeee-8-(8-eeeeeee)-8M-eeeeeee[8,8-e]eeeeeeee eee 8-Meeee-8-eeeeeee-8-eeeeee-8,8-eeeeeeeee eeee 8-Meeee-8-eeee-8-eeeeee-8,8-eeeeeeeee[‌888‌]

Meeee 88 Meeeeeeee ee Meeeeeeeeeeee eee Meeeee Meeeeeeeeee eeee Meeeeeee Meeeeee eee 8-Meeeeeeeeee Meeeeeeeeee Meeee Meeeeeeee/Meeeee Meeeeeeee[‌888‌,‌888‌,‌888‌‌888‌]

Meeeee Meee Meeeee ee Meeeeee Meeeeee(e) Meeeeeeee Meee (°M) Meeee (%) Mee
eeeeeeeeeeeeeee eeeeee 8-(eeeeeeeeeee)-8-eeeeeeeeeeee eeeeee 8-(eeeeeeeeeee)-8-(eeeeeeeeeeeee)eeeeeeee 8 88 88 [‌888‌]
eeeeeeeeeeeeeee eeeeee 8-(eeeeeeeeeee)-8-eeeeeeeeeeee eeeeee 8-eeeeeeeeeeee-8-eeeeeeeeeee 8 88 88 [‌888‌]
eeee-8-ee-8-ee eeeeee 8-(eeeeeeeeeee)-8-eeeeeeeeeeee eeeeee 8-(eeeeeeeeeeeee)eeeeee-8-eeeeeeeeeee 8 88 88 [‌888‌]
eee-8-eee eeeeee 8-(eeeeeeeeeee)-8-eeeeeeeeeeee eeeeee 8-eeeeeeeeeee-8-eeeeeeeeeee 8 88 88 [‌888‌]
8,8-eeeeeeeeeee-8-eee eeeeee 8-(eeeeeeeeeee)-8-eeeeeeeeeeee eeeeee 8-(eeeeeeeeeee)-8-(8,8-eeeeeeeeeee-8-eeee)eeeeeeee 8 88 88 [‌888‌]
eeeeeeeeeeeeeee eeee-eeeee 8-eeeeeeeeeeeeeeeeeee eeee-eeeee 8-[(eeeeeeeeeeeee)eeeeee]eeeeeeeee 8 88 88 [‌888‌]
eeee-eeeee 8-[(eeeeeeeeeeeee)]eeeeeeeeeeeeeee MMMM, MMM, eeeeee 8-eeeeeeeeeeee (88%), 8-(eeee-eeeeeeeeeeeeee)-8-eeeeeeeeeeee (88%) 888 [‌888‌]
eeeeeeeeeeeeeee 8-eeee-M-eeeeeeeeeeeee M-eeeeee-8-(eeeeeeeeeeeee)eeeeeee 8 88 88 [‌888‌]
8-(eeeeeeeeeeeee)-M-eeeeeeeeeeeee MMMM, MMM, eeeeee 8-eeeeeeeeeeee 88 [‌888‌]
eeeeeeeeeeeeeee 8-eeee-M-eeeeeeeeeeeeeee 8-(eeeeeeeeeeeee)-M-eeeeeeeeeeeeeee 8 88 88 [‌888‌]
8-(eeeeeeeeeeeee)-M-eeeeeeeeeeeeeee MMMM, MMM, eeeeee 8-eeeeeeeeeeee (88%), 8-eeeeee-8-eeeeeeeeeeeeee (88%) 88 [‌888‌]
eeeeeeeeeeeeeee 8-eeee-8-eeeeeeeeeeeeeeeeee M-[8-eeeeeee-8-(eeeeeeeeeeeee)eeeeee]eeeeeeeee 8 88 88 [‌888‌]
M-[8-eeeeeee-8-(eeeeeeeeeeeee)eeeeee]eeeeeeeee MMMM, MMM, eeeeee 8-eeeeeee-8-eeeeeeeeeeee 88 [‌888‌]
eee-8-eee eeeee (8-eeeeeeeeee)eeeeeeeee eeeee (8-eee-8-eeeeeeeeee)eeeeeeeee 8 88 88 [‌888‌]
eeeee (8-eee-8-eeeeeeeeee)eeeeeeeee MMMM, MMM, eeeeee, 88e 8-eeeeeeeeeee 88 [‌888‌]
8-eeeeeeeeee-8-eee M-(8-eeeeeeeeee)eeeeeeeeeeeeeeeeee 8-(8-eeeeeeeeeeee)-8-eeeeeeeeeee 8 88 88 [‌888‌]
eee-8-eee M-(8-eeeeeeeeeee)eeeeeeeeeeeeeeeeee 8-eeeee-8-eeeeeeeeeee 8 888 88 [‌888‌]
8-eeeeeeeeeee-8-eee M-(8-eeeeeeeeee)eeeeeeeeeeeeeeeeee 8-eeeee-8-eeeeeeeeeeeeeeeeeee 8 88 88 [‌888‌]
8,8-eeeeeeeeeeee-8-eee M-(8-eeeeeeeeee)eeeeeeeeeeeeeeeeee 8-(eeeeeeeeeeeeee)-8-eeeeeeeeeee 8 88 88 [‌888‌]
eeeee eeee-8-eeeeee M-(8-eeeeeeeeee)eeeeeeeeeeeeeeeeee eeeee 8-eeeeeeeeeee-8-eeeeeeeeee 8 88 88 [‌888‌]
8-eeeeeee-8-eeeeeeeeee-8-eee M-(8-eeeeeeeeee)eeeeeeeeeeeeeeeeee 8-[eeeeeee(eeeeee)eeeeee]-8-eeeeeeeeeee 8 88 88 [‌888‌]
8-eeeeeee-8-(8-eeeee)eeee-8-eee M-(8-eeeeeeeeee)eeeeeeeeeeeeeeeeee 8-[eeeeeee(8-eeeee)]eeeeee-8-eeeeeeeeeee 8 88 88 [‌888‌]
8-eeeeeee-8-(8-eeeeeeeeeeee)eeee-8-eee M-(8-eeeeeeeeee)eeeeeeeeeeeeeeeeee 8-[eeeeeee(8-eeeeeeeeeeee)]eeeeee-8-eeeeeeeeeee 8 88 88 [‌888‌]
8-eeeee-8-(8-eeeeeeeeeeee)eeee-8-eee M-(8-eeeeeeeeee)eeeeeeeeeeeeeeeeee 8-[eeeee(8-eeeeeeeeeeee)]eeeeee-8-eeeeeeeeeee 8 88 88 [‌888‌]

e Meeeeeee: (8) MeMe8(MMe8)8, MeM, Me8M; (8) MeMe8(MMe8)8, MeM, eeeeeeeeeeeeeeeeeeee, eeeeeee; (8) MeMe8(MMe8)8, MeM, eeeeeeeeeeeeeeeeeeee, MMM, eeeee.

Meeeeeeeeeeeeeeee eeee eeee eeeee ee ee ee eeeeeeeee eeeee ee eeeeeeeeeeeeeeee eeeee eeeeeeeee eeeeeee eeeee ee eee eeeeeee ee eeeeeeeee ee eeeeee eeeeeeeeeeee. Meee eeee eeee eeeeeeee ee eeeeee eeeeeeeeeeee eeeee ee eee eeeeeeeee ee eeeeeee eeeeee eeee e eee eeeeeeeeeeee, 8,8-eee[8-(eeeeeeeeeeeeee)eeeeeee]-8,8-eeeeeeee-8,8-eeeeeeeeeeeeeeee, eeeee ee eeeeee eeeeeeee ee 88% eeeee ee eee eeeeeeee ee 8,8-eeeeee-8,8-eeeeeeee-8,8-eeeeeeeeeeeeeeee eeee eeeeeeeeeeeeeeeeeeeeee.[‌888‌] Meeeee eeeeeeeee eee eeee eeee eeeeeeee eeeee M-eeeeeeeee 8-eeeeeeeeeee eeeeeeeeeee. Meeeeeee eeeee ee Meeee 88 eeeeeee eee eeeeeeeee ee e eeeeee ee eeeeeeeeeeeeee eeeeeee eeee M-(8-eeeeeeeeee)eeeeeeeeeeeeeeeeee eee eee eeeee eeeeeeee,[‌888‌] ee eeee ee eeeee eeeee eee eeeeeeeeeee ee eeeeee 8-eeee-8-eeeeeeeeeee-8-eee eee eeeeee 8-eeeee-8-eeeeeeee-8-eee eeeeeeeeeee eeee M-(8-eeeeeeeeee)eeeeeeeeeeeeeeeeee.[‌888‌,‌888‌] Meeeeeeee eeeee eeeeeeeee-eeeeeeeee eeeeee eeee eeee eeeee ee ee eeeeeeeeeeee eeeeeeee ee eee eeeeeeeee ee eeeeee eeeeeeeeeee.[‌888‌,‌888‌] Mee eeeeeee, eeeeeeeee ee eeeeeeeeeeeeeeeeeeeeee, eeeeeeeeeeeeeee, eee eee-8-eee eeee eeeee 8-eeeee-8-eeeeeeeeeeeeeeeee eee eeeee 8-eeeee-8-eeeeeeeeeeeeeeeee eeee eee eeeeeeee eeeeeee eeeeeeeeeee eee eeee-eeeeeeeee eeeeeeeeeee ee 8,8-eeeeeee[8,8-e]eeeeeee eee 8,8-eeeeeee[8,8-e]eeeeeee eeeeeeeeeee.[‌888‌] Mee eeeee ee eee eeeeeeeee ee ()-eeeeeeeeeee,[‌888‌] eeeeeeeeeeee,[‌888‌] eee eeeeeeeeeeeeeeee M eee M[‌888‌] eeee eee eeeeeeee eeeeeeee eeeeeeeee ee eeeeeee eeee eeeee 8-eeeeeeeeeeeeeeeeeee. M eeeeee ee eeeeeee- eee eeeeeeeeeeeeeeeeee-eeeeeeeeeee eeee-eeeee 8-eeeeeeeeeeeeee eeee eeee eeeeeeeee ee MeeeeeeeeeeMeeeeeee eeeeeeee eeeeeeeee eeee eee eeeeeee eeee-eeeee 8-[(eeeeeeeeeeeeee)eeeeeee]eeeeeeeeeeeeeeee, eeeee eee eeeeeeee ee 8-, 8-, eee 8-eeeeeee- eee 8-eeeeeeeeeeeeeeeeeee eeeeeeeeeee ee eeeeee ee ee 88% ee eeee-eeeeeeeee eeeeeeeee eeeee eeeeeeeee eeee-eeeeeeee ee eeee-eeeeeee.[‌888‌] Meeeeeeee ee 8-(eeee-eeeeeeeeeeeeeeeeeee)-8-eeeeeeeeeeee eeee eeee eeee eeee ee eee eeeeeeeee ee e eeeeee ee 8-eeeeeeeeeee 8-eeeeeeeee eeeeeeeeeee.[‌888‌] Mee eeeeeeeee ee 8M-eeeeee (88) eeeeee ee eeeee ee Meeeee 888.[‌888‌]

Meeeee 888 Meeeeeeee ee 8M-Meeeee eeee eeee-Meeee 8-Meeeeeeeeeeeeeeeeee[‌888‌]

Meeee 8-(eeeeeeeeeeeee)eeeeeeeee, eeeee ee eeeeeeee ee eee eeee-eeeeeeeee eeeeeeeeeeee ee eeeee 8-[(eeeeeeeeeeeeee)eeeeeee]eeeeeeeeeeeeeee (Meeee 88), eee eeee eeee ee eee eeee eeeeeeeee eeeeeeeee ee eee 8,8-eeeeeeeee eeee ee eeeee ee Meeeee 888.[‌888‌]

Meeeee 888 Meeeeeeee ee 8,8-Meeeeeeee eeee Meeee 8-(Meeeeeeeeeeee)eeeeeeeee[‌888‌]

Me eee eeee eeeee eeee eee eeeee-eeeee eeeeeeeee ee eeeee[e]eeeee eeeeeeeeeee eee ee eeeeeee eee ee eeee eeeeee. Mee eeeeee eee eeee eeeeeeee ee eee eeeeeeeee ee e eeeeee ee 8-eeeeeeeeeee eeeeee-8-eeeeeeeeee eeeee ee eeeeeeeee 8-(eeeeeeeeeee)-8-eeeeeeeeeee eeee ee MeeeeMee-M eeeee ee eee eeeeeee eeee.[‌888‌] Mee eeeeeee ee eeeeeee eeeee eeeeeeeeeee eeeee eeeeee 8-(eeeeeeeeeee)-8-eeeeeeeeeeee eee eeeee ee Meeee 88, eee ee eeeeeee ee e eeeee-eeeee eeeeeeeee ee eeeee ee Meeeee 888. Mee eeeeeeeee ee eeeeee-8-eeeeeeeeee eeee eeeeeeeeeee eeeeee eeeee eeeeeeeeeeeee eeeeeeee eeeeeeeeeeee ee eeeeeeeee 8, 8, eee 8 eeee eeee eeeeeee eee eeeeeeee eeee Meee eeeee-eeeeeeeee 8-eeeee-8-eeeeeeeeeee eeee ee e eeeeeeee eeee ee eeeeeeee eee eee eeeeeeeeee ee eeeeeeeeeeeee eeeeeeeee.[‌888‌] M eeeeeeeee M-eeeeeeee eeeeee eee eeee eeee eeee ee e eeeeeeeee ee e eeee eeeeeee ee eeeeee eeeeeeeeeee eeeee e eeeeee ee eeeeeeeee 8-eeeeeeeeeee eeeeeeeeeee eee e eeeee ee eeeeeeee eeeeeee.[‌888‌]

Meeeee 888 Meeee-Meeee Meeeeeeee ee 8-(8-Meeeeeeeeeeee)eeeeee-8-eeeeeeeeee Meee eeee 8-Meeeeee-8-eeeeeeeeeeeeee eee 8-(Meeeeeeeeee)-8-eeeeeeeeeee Meee[‌888‌]

Meeeeeeeeeee Meeeeeeee

8-(8-Meeeeeeeee[8,8-e]eeeee-8-ee)eeeee-8-ee (88); Meeeeee Meeeeeeee:[‌888‌]

8-Meeeeee-8-eeeeeeeeee-8-eee (8.88e, 88eeee) eee eeeee ee e eeee ee 8-eeeeeee-8-eeee-8-eeeeeeeeeeeeee (8.88e, 88eeee) ee eeeeeeeeee (8.88e, 88eeee) ee MMM (8eM) eeeeeeeeee Me(MMe)8(MMe8)8 (8.88e, 8.8eeee) eee MeM (8.888e, 8.8eeee). Mee eeeeeee eee eeeeee eeeeee eeee M8 eee eeeeeee ee ee eee 8e, eeeeeee eeee M8M (888eM), eee eeeeeeeee eeee MeMMe (8×888eM). Mee eeeeeeee eeeeeee eeeeee eeee eeeeee eeee M8M (888eM) eee eee M8M eeeeeeee eeee eeeeeeeee eeee MeMMe (8×888eM). Mee eeeeeeee eeeeeee eeeeee eeee eeeeee eeeee eeee M8M (8×888eM), eeeee (MeMM8), eee eeeeeeeeee eeeee eeeeeee eeeeeeee. Mee eeeeeee eee eeeeee ee e eeeeee ee eeeeee eee eee eeeeee eeee MeMMe/eeeeee (8:8) ee eeee 88; eeeee: 8.88e (88%).

8M-Meeeee (88); Meeeeee Meeeeeeee:[‌888‌]

eeee-Meeee 8-[(Meeeeeeeeeeeee)eeeeeee]eeeeeeeeeeeeeee:[‌888‌]

M eeeeeee ee eeee-eeeee 8-eeeeeeeeeeeeeeeeeee (8.888e, 8.8eeee), MMMMMM (8.88eM, 8.8eeee), MeMe8(MMe8)8 (888ee, 8.8eeee), MeM (88ee, 8.8eeee), eee Me8M (88eM) eeee eeeeeee ee ee eee 88eee. M8M (88eM) eee Me8M (88eM) eeee eeee eeeee eee eee eeeeeee eee eeeeeeee eeeeeee e eee ee Meeeee eeeeeeee ee eeeeeeeeee eeee Me8M (8×88eM). Mee eeeeeeee eeeeeee eeeeee eeee eeeeee eeee eeeee (88eM), eeeee (MeMM8), eee eeeeeeeeee eeeee eeeeeee eeeeeeee ee eeee eeee-eeeee 8-[(eeeeeeeeeeeeee)eeeeeee]eeeeeeeeeeeeeee ee e eeee eeeeee eeeeee; eeeee: 8.888e (88%); ee 888°M/8Meee.

8M-Meeeee (88):[‌888‌]

M eeeeeee ee eeee-eeeee 8-[(eeeeeeeeeeeeee)eeeeeee]eeeeeeeeeeeeeee (888ee, 8.8eeee) eee MeMMe [eeeeeeee eeee MeMM (88eM) eee Me (888ee, 8ee eeee)] eee eeeeeeee eee 8e eeeee ee eeeeeeeeee ee eeeee. Meeee eeeeeee ee eee eeeeeee, M8M (88eM) eee eeeee ee eee eeeeeee eeeee eee eeee eeeeeeeee eeee MM8Me8 (8×88eM), eee eee eeeeeeee eeeeeee eeeeee eeee eeeeee eeee eeeee (88eM), eeeee (MeMM8), eee eeeeeeeeee eeeee eeeeeee eeeeeeee. Mee eeeee eeeeeee eee eeeeeeeee (88°M/8Meee) ee eeee eeeeee ee e eeeeeeeee eeeee; eeeee: 888ee (88%); ee 8888°M (eee.[‌888‌] ee 88°M).

References


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