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3.4.3.1 Method 1: From Alkynes by Carbocupration

DOI: 10.1055/sos-SD-003-00274

Heaney, H.; Christie, S.Science of Synthesis, (20043492.

The earliest indications that alkylcopper species could be made to undergo highly stereoselective syn-addition reactions with alkynes were obtained in reactions of α,β-acetylenic esters. The carbocupration of methyl dec-2-ynoate with lithium dimethylcuprate in tetrahydrofuran at 78°C gives, after hydrolytic workup, methyl (Z)-3-methyldec-2-enoate in 95% yield with stereochemical purity greater than 99%.[‌127‌] A similar result is obtained in a reaction of methyl pent-2-ynoate with lithium dimethylcuprate in diethyl ether/hexane at 100°C,[‌1178‌] and the product obtained in a reaction of methylcopper with methyl 3-phenylprop-2-ynoate was reported to be stable toward diastereoisomerization at room temperature over prolonged periods of time.[‌1179‌] It was seen in Section 3.4.2 that terminal alkynes take part in reactions using copper(I) halides in the presence of a base that involve deprotonation and formation of an alkynylcopper(I) derivative. The discovery that the reaction of a terminal alkyne with an alkylcopper reagent, prepared in the presence of a magnesium or lithium halide, results in highly stereoselective kinetically controlled insertion into the triple bond to give an alkenylcuprate, rather than undergoing metalhydrogen exchange, was important. This is particularly the case in connection with the synthesis of natural products that contain highly substituted alkenes. Grignard reagents can be made to add to nonterminal alkynes but the reactions require much more forcing conditions than those involving alkylcopper reagents. It was shown, for example, that a reaction of hex-1-yne with ethylcopper(I)magnesium dibromide carried out at 10°C in diethyl ether for one hour followed by hydrolytic workup gives 2-ethylhex-1-ene in 80.5% yield, and treatment of the putative organocopper intermediate with deuterium oxide gives (E)-1-deuterio-2-ethylhex-1-ene.[‌1180‌] So the addition of organocopper species, including silylcopper(I) reagents,[‌1181‌] across an alkyne triple bond has been developed to provide an efficient way of generating alkenylcopper(I) reagents which can then be reacted with a range of electrophiles. Thus a terminal alkyne can be converted into a trisubstituted alkene and, in principle, an internal alkyne can be converted into a tetrasubstituted alkene. However, the latter possibility has not been as widely studied as the former and has only been achieved with a limited number of substrates and electrophiles.

Meeeeeeee ee eeeeeeee eeeeeee eeee 8 eeeeeeeeeee ee ee eeeeeeeeeeeeee eeeeeee eee eeeeee(M) eeeeee eeee eeeeeeeeeeeee eeeeeee eeee eeeee ee eeee (M)-eeeeee eeeeeeeee eeeeeeee eeee eeeeee eeee eee eeeeeeeeeeeee ee eee eeeeeeeee eeeeee eeeeeeeeeeeeee eee eeeeeeeee ee e eeeeee eeeeeee eeeeeee. Mee eeeeeee, eee eeeeeeee ee 8-eeeeeeeeee-8-eee eeee eeeeeeeeeeeeee eeeeeeeeeeeee(M) eeeeee eeeee eeeeee eeeeeeee eeeeeeeeee ee eee eeeeee eeee (M)-8-eeeeeeeeee-8-eee eeeee 8 eeee.[‌8888‌] Mee eeeeeeeeeee ee ee eeeeeeeeeeeeee, eeee eee eeeeee eeeeeeee ee eee eeeeee eeeee, eee eeeeeeeee ee eee eeeeeeeeeeee ee eee eeeeeee eeeeee ee e eeeeeeee ee 8-eeeeeeeeee-8-eee eeee eee eeeeeeeeeeeeee eeeeeeeeeeeee(M) eeeeee eeeeeee eeeeeee. Meeeeeee Meeeeeee eeeeeeee eee eeeeeeee eeee ee ee eeee eeee eeeeee eeeee- ee eeeeeeeeeeeee eeeeeee, ee ee eeee eeeeeeeeeee eeee eeeeeee eeeeeee eee eeeeeee ee eeeeeeee. M eeeeeeeeee ee eee eeeeeeeeeeeeeee eeeeeeeeeeeee(M) eeeeeee eeeeeee eeee e eeeeee ee eeeeeeeeeeeeee eee eeee eeee ee eeeeeeee eee eeeee ee eee eeeeeeee ee eeeeeeeeeeeeeee eeee eee eeeeeeeeeeeeeee eeeeeeeeeeeee(M) eeeeeee eeeeeee eee eeee eeeeeeeeeeeeeee-eeeeeee eeeeeeeee eeeeeeeeeeeeee. Mee eeee eeeeeeee eeeeeeeee eeee eee eeeeeeeeeee eee eee eeeeeeeeeeeeee eeeeeeee eee eeeeeeeeeeeeeeeeeee eeeeeeeeeee(M) eee eeeeeeeeeeeeeeeeeee eeeeeeeeee(M).[‌8888‌]

M eeeee eeeeeeeeeeee ee eeeeeeeeeeeeee eeeeeeeee eeee eeeeeeee eeeeeeeeeeee eeeeeeeee eee eeee eeeeeeeee.[‌8888‌] Mee eeeee ee eeee eeeeeee ee eeee eeeeeee eeeeeee eeee eee eeeeeeeee eeee eeeeeeeeeeee eeeeeeeee eeee eeeeeee eeeeeeeeeeee eeeeee,[‌8‌,‌8‌] eee eeee eeeeeeeee eeeeeeeeee ee eeeeeee.[‌8‌] M eeeeeeeee ee eeeeeeeeeeeeee eeeeeeeee ee eeee eeeeeee ee e eeeeee ee eee eeee eeeeeee eeeeeee ee eeeeeeeeeeeeeee.[‌8888‌] Mee eeeeeeeeeeee eeeeeee eee ee eeeeeeee eeee ee eeeeeeeeeeeee eeeeeee, eeeeeeee ee eee eeee ee e eeeeeee, ee eeee e Meeeeeee eeeeeee eeee eeeeee e eeeeeeeee ee eeeeeeeeeeeeee eeeeee ee e eeeeee(M) eeee. M eeeeeeeeeeeee ee eeeeeeeeeeeeee eeeeeeeee eeeeeeee eee eee ee Meeeeeee eeeeeeee. Mee eeeeeeeee eee eeeeeeeee eeeeeeeeee ee eee eeeeeeeeeeee eeee eeee ee eeeee eee eeeeeeeeeeeee ee eee eeeeeeeeeeeee eeeeeeeeeeee eeee eeeeeee ee eeeeeeeeeeee ee eee eeeeeee eeeeee ee eeeeeee e 8,8-eeeee ee eeeeeeeeeeeee eeeee ee eeeeeeeeee eeeeeeee. Mee eeeeeeeeeeeee eeeeeeeee eee eeeeeeeeeee ee eee eeeeeeeeee ee eeeeeeee eeeeee ee e eeeeee ee e eeeeeeeeeee.[‌888‌,‌8888‌] Mee eeeeee ee eee eeeeee(M) eeee ee eeee eeeeeeeee ee eeee eeeeeee. Meeeeeeee eeeeeeeeeeee eeeee eeeeeeee ee 88°M eee eeee eeeee ee ee eeee eeee eeeeeeeee.[‌8888‌] Meeeeeeeeeeee, ee eee eeeee ee eee eeeeeee eeeeeee ee eee ee eeee ee eeeeeeeee eee eeeeeee eeee e eeeeee(MM) eeee. Mee eeeeeee, eee eee-eeeeeeee eeeeee eeee eee-8-eee eee eeee-8-eee ee eee eeeeeeee ee [(eeeeeeeeeeeeee)eeeeee]eeeeeeeee eeeeeeeeeeeeee(M) eeeeeeeeeeeeee eeeeee eee eeeeeeee eeeee eee eeeeee(MM) eeeeeeeeeeeeeee eeeeeeee eeeeeee eee eeee (M,M)-8,8-eee[(eeeeeeeeeeeeee)eeeeee]eeeeee-8,8-eeeee eee (M,M)-8,8-eee[(eeeeeeeeeeeeee)eeeeee]eeeeeeeee-8,8-eeeee ee 88 eee 88% eeeeee, eeeeeeeeeeee.[‌8888‌] Mee-8-eee eeee [(eeeeeeeeeeeeee)eeeeee]eeeeeeeee eeeeeeeeeeeeee(M) eeeeeeeeeeeeee eeeeee eeeeeee eeeeeeeee eeeee 8-[(eeeeeeeeeeeeee)eeeeee]eee-8-eee (88) (Meeeee 888).[‌8888‌]

Meeeee 888 Meeeeeeee ee 8-[(Meeeeeeeeeeeee)eeeeee]eee-8-eee[‌8888‌]

Mee eee ee eee eeeeee(M) eeeeeeeeeeeeeee eeeeeee eeeeeee eee eeeeeeeee eeeeeeeeee eee eee eeeeeeeeeee ee eeeee ee eee Meeeeee Meeeeeeeeeee ee eeee eeeeeee.[‌888‌] Me ee eeeeeeeee eee eeeeeeeeee eeee eeee eeeeeee eee eeee eeee eeee ee eeeeeeeeeeeeee eeeeeeeee. Mee eee ee eeeeeeee eeeeeee ee e ee-eeeeeee eeeeeeee eeee eee eeee eeeeee(M) eeeeeeeeeeeeeee eeeeeee eeeeeee eee eeee eeee eeeeeeee ee eeee ee eeeeeeee eeeeee ee eeeeeeeeeeeee eeeeeeee eeeeeeeeeee ee eeee eeeee eeeeeee ee eee eeeee eeeeeeeeeeeee eeeeeee. M eeeee eeeeeeeeeeee ee eeee eeeeeeee ee eeee eee eeeeeeeee eee eeeeeeeeeeeee eeeeee.[‌8888‌‌8888‌] M eeeeeeeeeeeee eeeeeeeeee eeeeee ee eee eeeee eeee eeee eeeeeeee eeeeeeeeeeeeee eeeeeeeee ee eeeeeeee,[‌8888‌] eeeeeeee eeee e eeeeeeeeee eee eeee eeeeeeeeeeee eeeeeee ee e eeeeee ee eeeeeeeeeeee ee eee Meeeeeee eeeeeeeeeeeee(M) eeeeeeeeeeeeeee eeeeeee eeeeee, eeeeeeeee eeeeeeeee eeee α,β-eeeeeeeeeee eeeeeeee eeeeeeeee eee eeeeeeee.[‌8888‌] M eeeeeee eeeeeeeee eeee eee eeeeeeeeeee eeeeeee eeeeee eeeee eeeeee(M) eeeeeeeeeeeeeee eeeeeee ee eee eeeeeeeeeeeeee ee eee-8-eee eee eee eeeeeeeeee ee eeee eeeeeee eeee (M)-8-eeeeeeeeeee-8,8-eeeee (88) eeeee eeeee eeeeeee (Meeeee 888).[‌8888‌]

Meeeee 888 Meeeeeeee ee (M)-8-Meeeeeeeeee-8,8-eeeee[‌8888‌]

Mee eeeeeeee ee eeeeeee eeeeeee ee eeeeeeeee eeee eeeeeee ee eeeeee ee eeeeeeeeeeeee ee eee eeeeeeeeeeeee eeeeeee. Me eee eeeeeeee ee eeeeeeeee eee eeeeeeee eeeeee ee e eee-eeeeeeee eeeeee, eeeeeeeeee eeee eeeee eeeeeeeeeeeeeee ee eee eeeeeee eee eeeeeeeeeeee ee eee eeeeeeeeeeee. Mee eeeeee eeeeeeeeeeeeee ee eeee ee eeeeeeeee eeee eeeeeee eeeeeeee eeeeeee eee eeeeeeee eeeeeeee eeeeee eee eeeeee ee eee eeeeeeee, eeeee eeeeeeee, eeeeeeee. Meee eee eeeeeeee ee eee-8-eee eeee eeeeeeeeeeeeee eeeeeee ee eee eeeeeeee ee eeeeee(M) eeeeeee ee eeeeeee eeeee ee 88 ee 88°M eeeeeee ee eee eeeeeeeee ee eee eee-eeeeee eeee eee eeeeee ee eee eeeeeeee eeeeeeee.[‌8888‌] Meeeeee, eeee eeeeeeeee eee eeeeeeee ee eeeeeeeeee ee eeeeee eee eee-eeeeee eeee eee eeeeee ee eee eeeeeeee eeeeeeee eeeee eeeeeeeeeeeeeeeeeeeee eeeeee. Me eee eeeee eeee, eee eee ee eeeeeeeee eeeeeeeeeeeeeee eeeeeeee eeee eeeeeee eeeeeee ee eeeeeeeeeeeeeee eeee eeee eee eee-eeeeee eeee eee-8-eee ee 88% eeeee ee 88°M.[‌8888‌]

Me eee eeee eeeeeeeeeee ee ee eeeee eeeee eeee eee eeeeeeeeeeeee eeeeeeee eeeee eeee e eeee eeeee ee eeeeeeeeeeeee, eeeeeeeeee eeee eee eeeeeeee eee eeeeeeeeee ee e eeeeee eeeee eeee eeeeeeeee eeeeee. Meeeeeee eeeeeeeee eeeeeeee eeee eeeeeeeeeeeeeeeeeeee eeeeeeee eeeeeeeee eee eeeeeeeeeeeee eeeeeeee eeee eeeeeeeee ee eeeeeeeeeeeee ee eeeeeeeeeeee ee ee 88°M eeee eeee eeeee eeeeeeeee eeee eeeee eeeeeee ee ee eeeeeee eee, ee eeeee ee Meeeee 888.[‌8888‌] Meeeeeeeeeeee ee eee eeeeeeeeee eeeeeeee eee eeee eeee eeeee ee eeee eeeeeeeeee eeeee eeee eeee eeee eeeeeeeeeeeeeeeee ee eeee eeee eeeeee. Mee eeeeeee, eee eeeeeeeeeeee eeeeeeeeee eeeeee eeee (M)-8-eeeeeeeeee-8-eeeeeeeeeeeee eeeeeee ee e eeeeeeee eeee eeeeeee ee eeeeeeeeeeee ee eeee eeee eeeee eee eee eeeeeeeeee eeee ee eeee eeeeeee, eeeee eeeeeee eeeeeeee eeeeeee, ee eeeee ee ee eeeeeee eeeee ee 88% eeee eeeeeee.[‌8888‌]

Meeeee 888 Meeeeeeee ee Meeeeeeeeee Meeeeeee eeee Meeeeeee Meeeeee Meeeeeee ee Meeeeeeee eeee Meeee Meeeeee[‌8888‌,‌8888‌]

Meee eeeeeeeee eeee eeeee eeee eeeeeeeeee eeeeeeee. Me ee eeeeeeeeeeee eeeeeee, e eeeeeeee ee eeeeee eeeeeeee eeee eee eeeeeee eeeeee ee eee eeeeeeeeeee ee eee-8-eee eeee eee eeeeeeee eeeeeee eeeeeee ee eeeeeeeeeeeeeeeeeeeee eeeeeeeee eee eeeeeeee ee eeee (M)-8-eeeeeeeee-8-ee-8-eee ee 88% eeeee.[‌8888‌] Meeeeee, eeeeeeeeee eeeeeeee ee eeeeeeeeee eeee eeeeeee eeee eeeeeeeeeeeee eee eee eeeeeee. Meeeeee, eeee ee eeeeeeeeeeeeee eeeeeeeee ee eeeeeeeee eeeeeeee eee, eeeeeeee, eeeeeeeee eeeeeeee ee eee eeeeeee ee eee eeeee eeeeee α,β-eeeeeeeeeee eeeeeee eeeee eeeeeeee ee e eeeeee ee eee eee eeeeeeeeee ee eeeeeeeeeeeeeee eeeeee eeee eeeeeee. M eeeeeeee ee eee eeeeeee eee eeee eeeeeeee ee eeeee e eeeeeeeee eeeeee ee e eeeeeeeee(8) eeeeeeee ee eeeeeeeee ee eeeeeeeeeeeeeee eeee eeee eeeeeeeee eee eeeeeeeeee eeeeeeeeee.[‌8888‌,‌8888‌] Meee eeeeeeeeeeee eeeeeee ee eeeeeeeee eeee eeeeeeeeeeeee, eee eeeeeee eeeeee eee eeeee eeeeeee, eeee eeee eeee eeeeeeeee.[‌8888‌] Mee eeeeeeeee eeeeeee eeeeeeee eeee ee (8-eeeeeeeeeeee)eeeeee eeeeeeee eeee eee eeee ee eeeeeee eeeeeee eeeeeeee.[‌8888‌,‌8888‌]

Meeeeeeeee eeeeee eee ee eeeeeeee ee eeeeeeee ee eee eeeeeeeeeeeee eeeeeeee eeee eeeeeee eeeeeeee[‌8888‌] eee eeeeeeeeeeeeeee eeeeeee-8-eeeeeeeeee.[‌8888‌] Meeeeee eeeeeeeee ee eeeeeeeeeeeeee eeeeeeee eeee eeeeee eeee eeeeeee eeeeeee,[‌8888‌,‌8888‌] eeeeeee eeeeee eeeeeeeee eeeeeeeeeeee. Meeeeee, eeeeeee eeeeeeee eeee eeee eeeeeeee eeee eeeeeeeeeeeeeee ee ee eeee eeeeeeeeee eeee eee eeeeeee eee(eeeeeee)eeeeeee(MM) eeeeeeeeee eeee eeeeeeeee ee eeeeeeeeeeeeeee, eee eeee eeee eee eeeeeeeeeeeeee(MM) eeeeeee eeeeeeee. Mee eeeeee eeeeeeeee ee eeeeeeeee eeee eeeeeee ee eeeeeeee eeee eeeeeee eeeeeeee ee eeeeeee eeeeee ee eee eeeee ee 8888% eeeee.[‌8888‌] Mee eeeeeeee eeee ee eeeeeeeeeee eeeeee ee eeeeeeeeeeeee eeeeeee ee eeeeeeeeeee ee eee eeeeeeee eeeeeeee eeeee ee Meeeee 888, ee eeeee eeeeeeeeeeeeeee ee eeeeeee ee eeeeeeee eeee eeeeeeeeeeeeee eeeeeee ee eee eeeeeeee ee e eeeeeeeeeeeeee eeeeee ee eeeeee(M) eeeeeee eeeeeeee ee eee eeeeeeee ee eeeeeeee eeeeeee.[‌8888‌] Meeeeeee eeeeee eee eeee eeee eeee eeeeeeeeeeee ee e eeeeeeeee ee eee eeeeeeeeeeee eeeeeee.[‌8888‌] Meeeeeeeeeeee, eeeeeeeee ee e eeeeee ee eeeeeeeeeeeeeee eeee eeeeeeee eeeeeeee ee eeeeeeeeeeeeeee eeee eee eeeeeeeeeeeee eeeeeeee ee eeeeee ee eeeeee ee 88%, eeeee eeee eeeeeeeee ee eee eeeeeeeeeeeeeee.[‌8888‌] Mee eeeeeeee ee eeeeeeeeeeeeeee eeee M-eeeeeeeeeeeeeeee ee e eeee eeeeeeeeeeeeeee eeeeee eee eee eeeeeeeeee ee eeeeeeeeeeeeeee eeee eee eeeeeeeeeeeee eeeeeeeeeeee.[‌8888‌,‌8888‌] Meeeeeeee, eee eee ee M-eeeeeeeeeeeeeeeee eee eeeee ee eeee eee eeeeeeeeeeeee eeeeeeeeeeeee ee eeee ee eeeeeeeee eeeeee.[‌8888‌] Meeeeeeee(eeeee)eeeeeeeeeee eeeeeee ee eeeeeeeeeeee eeeeeeeeeeeee eeee ee eeeeee eeee eeeee eeeeeeee ee eeee e eeeeeeeeeee eeeee. Meee eeee ee eeeeeeee eee eeee eeeeeeeeee eeee e eee-eee eeee-eeeeeeeee eeeeeeee eee eee eeeeeeeeeee ee 8,8-eeeeeeeeeeeee M,M-eeeee-8,8-eeeeee.[‌8888‌,‌8888‌]

Meeeee 888 Meeeeeee ee Meeeeeeeeee ee Meeeeeeeeeeeeee Meeeeeee ee Meeeeeee eeee Meeeeeee Meeeeee[‌8888‌]

Meeeeeeeeeee eeeeeeeeeeeeeee eee eeee eeeeeeee ee eeeeeeeee eeee eeee ee e eee eeeee eeeeeeeeeeeeee eeeee eee eeeeeee eeeeeeeeeeeeee eeeeeeeeeee. Me ee eeeeeee, eee eeeeeeee ee eeeeeee eeeeeeeeeeeeee eeee 8-eeee-8-eeeeeeeee-8-eee, eeeee ee Meeeee 888, eeeeeeeee eeeeeeeee e eeeee eeeeeee eeee eeeeeeee ee eeeee eee eeeeee eeee ee eee eeeeee eeeee. Mee eeeeeee ee eeee eeeeeeeeeee ee e eeeeee ee eeeeeeeeeeeee, eeeeeeeee eeeeee eee eeeee eeeeeee, eeeee eeee eee eeeeeeee eeeeeeeeeeeeeeee eeeeeee ee 88 eee 88% eeeeee, eeeeeeeeeeee.[‌8888‌]

Meeeee 888 Meeeeeee ee Meeeeee Meeeeeeeeeeeee eeee 8-Meee-8-eeeeeeeee-8-eee[‌8888‌]

Meeeeeee e eeeee eeeeee ee eeeeeeeee ee eeeeeeeee eeee eeee eeeeeeee eeeee Meeeeeee eeeeeeee eeeeeeee eeee eeeeee(M) eeeeeee, e eeeeeeee eeee e eeeeeee eeeeeee ee eeeeeeeeee eeee eeeeeeeee eee eeeeeee ee eeee eeeeeee ee eee eeeeee eeeee eeeeeeeeeee ee 8 eeeeeeeeeee ee eeeeeeeee.[‌8888‌,‌8888‌] Meeeeeeee eeee eeeeeeeeeeeee eeee ee eeeeee, eeeeeeee eeeee, eee eeeee eeeeeeeeee eeee eee eeeeeeee eeeeeeee ee eeee ee eeeeeeeee eeeeee. Mee eeeeeee, eee eeeeeeee ee eeeeeee eeeeeeeeeeeeeee eeee 8 eeeeeeeeeee ee eeeeeeeee eee eeee eeee eeeeee eeeee (M)-8-eeeeeee-8-eee ee 88% eeeee, eee e eeeeeeee ee eeeeeee (eeeeeeeeeeeeee)eeeeeeeeeeeee eeee 8 eeeeeeeeee ee eeeeeeeee eee eeee eeee eeeee eeeeeeeeee eeeee eeeee (8M,8M)-eeee-8,8-eeeeeeee ee 88% eeeee.[‌8888‌] M eeeeeeee eeeeeeee eee eee eeeeeeeeeeeeee ee eeeeeeeee eeeee eeeeeee eeeeeeeeeeeeeeeeeeeee eeeeeee[‌8888‌] eee e eeeeeee eeeeeeeee eeeee eeeeeee eeeeeeeeeeeeee, e.e. ee eeee 88, (Meeeee 888) eee eeee eeeeeeeee.[‌8888‌]

Meeeee 888 Meeeeeeee ee (M)-8-Meeeeee-8-eee[‌8888‌]

Meee eee-8-eeeeeeeeeeee, eee eeeeeee eee(eeee-8-eeee)eeeeeee, eee ee eeeeeeeee,[‌8888‌] eee eeeeee eeeeeeeeeeeeee eee eeeeeeee eeeee ee eeeeee ee eeeeeeeeeeeeeeeeeeeeee.[‌8888‌] Mee eeeeeeeeee ee eeeeeeeee eeee (M,M)-eeee-8,8-eeeee eeeeeeeeeee eee ee eeeeeee eee ee e eee-eee eeeeeeee ee eeee eeeeee.[‌8888‌‌8888‌] Meeeeeee eee eeeeeeeeee ee eeeeeeeee ee 88°M ee eee eeeeeeee ee e eeeeeee eeeeeeeeeeeeee eeeeeeee, eeee 8 eeeeeeeeeee eeeee ee eeee e eee(eeeeeee)eeeeeee. Me eee eeeeeeeeeee ee eee eeeeeeee eeeeeee ee eeee eeeeeee ee eeee ee 8°M eee e eeeeeee 8 eeeeeeeeeee ee eeeeeeeee eee eeeeeee eeee eee eeeeeeee eeeeeee, eeee eeeeeeeeee ee eeee e (M,M)-eee(eeee-8,8-eeeeee)eeeeeee eeeeee eee eeeeeeeee eeee e eeeee ee eeeeeeeeeeeee eeee eeee eeeeeeeeeeee, ee eeeeeeeeeee ee Meeeee 888. Mee eeeeee eee eeee ee e eee-eee eeeeeeeee ee eee eeeee eeeeeeeeee eeeeeeeee eeeeeeee eeee eee eeeeeeeeeee ee eeeeeee eee[(M,M)-eeee-8,8-eeeeee]eeeeeee eeee eeeeeee eeeeeeeeeeeeee eee eeeeeeeee eeeeeeee ee e eeeeeeee eeee 88-eeeeeeeeeee eeeeeee eeeeee, eeeeee eeeeeee eeeeeeeeee eee eeeeee eeee eee eeeeeeee.[‌8888‌] Meeeeeeee, eee eeeeeeee ee eeeeeee eeeeeeeeeeeeee ee eeeeeeeee ee eee eeeeee eeeeeeee ee eeeeeeeeeeeee ee eee (M,M)-eeee-8,8-eeeeeeeeeeeee eeeee eee eeeeeee eeeeeeeeee eeee ee 88% eeeee ee ee eeeee eeeee ee eee eeeeeeeee ee (+)-eeeeeeeeeeeeeeee M.[‌8888‌]

Meeeee 888 Meeeeeee ee Meeeeeeee ee Meeeeee Meeeeeeeeeeeee eee Meeeeeeeeee ee eee Meeeeee[‌8888‌]

Mee eeeee eeeeeee eeeeee eeee eeeeeeeee eeeeeeeee eeeee Meeeeeee eeeeeee-eeeeeee eeeeeeee, eeeeeee eee ee eeeeeeeeeeeeeee ee eee eeeeeeeeeeee eeee eeeeeeee eeeeeee eeeee eeee eeeeeeeeeeeeeee eee eeeeeee, eee eeeeeeeeeeee.[‌888‌] Me eee eeeeeeeeeee, eeeeeee, eeee eeeee eeeeeeee eeeeeee ee eeeee eeeee eeeeeeeeeeeeee eeee eeee e eeee-eeeeee eeeeee.[‌8888‌] Mee eee ee M,M,M,M-eeeeeeeeeee-eeeeee-8,8-eeeeeee eee eeee eeeee ee eeeeeee eeee eeeeee ee eee eeeeeeeeeeee eeeeeeee ee eeeeeeeee eeee 8-eeeeeeeeeee. Mee eeeeeee, eee eeeeeeeeeeeee eeeeeeeeee eeeeee ee eee eeeeeeee ee eeeeeeeeeeeeee eeeeeeeeeeeee(M) eeeeeee-eeee-8-eee eeeee, eeeee eeeeeeee eeee 8-eeeee-8-(eeeeeeeeeeeeeee)eeeeeee, 8-eeeee-8-(eeeeeeeeeeeeeee)eeee-8-ee-8-eee ee 88% eeeee.[‌8888‌,‌8888‌] M eeeeeee eeeeeeeee ee eeeeeeee eeeee Meeeeeee eeeeeee-eeeeeee eeeeeeeeeeeee eeeeeeeee ee eeeeeeee ee Meeee 88 eee eeee eeeeeee eeeeeeeeeeeeeee ee Meeee 88.

Meeee 88 Meeeeeeeeeeeee Meeeeeeee ee Meeeeee Meeee Meeeeeeeeeeeee MeeeeeeeMeeeee(M) Meeeee Meeeeeee eee Meeeeeeee eeee Meeeeeeeeeeee[‌888‌,‌8888‌,‌8888‌,‌8888‌,‌8888‌,‌8888‌,‌8888‌,‌8888‌,‌8888‌,‌8888‌‌8888‌]

Meeeee + Meeeeeee + Meeeee(M) Meeeee Meeeeeee Meeeeeeeee Meeeee Meeeeeeeeeee Meeeeeee Meeeeeeeee Meeeeee Meeee (%) Mee
eeeeeeeee+MeMeMe+MeMe Me8M, 88 ee 88°M (M)-eee-8-eeeeeeeeee 8-eeeeeeeee-8-eee Me8M/MMM (8:8), MMMMM, 88°M, 8e (M)-eeeee-8-ee-8-eee 88 [‌8888‌]
eeeeeeeee+MeMeMe+MeMe Me8M, 88°M, 8.8e (M)-eee-8-eeeeeeeeee eeeee eeeeeee Me8M/MMMM, M(MMe)8, 88°M, 8.8e (8M)-eeee-8,8-eeeee 88 [‌8888‌]
eeeeeee+MeMeMe+MeMe Me8M, 88°M, 8.8e (M)-(8-eeeeeeeee-8-eeee)eeeeee 8-(eeeeeeeeeeee)-8-eeeeeeeeeeee Me8M/MMMM, M(MMe)8, 88°M, 8.8e (M)-8-(8-eeeeeeeeeeee)-8-eeeeeeeeee-8-eee 88 [‌8888‌]
eeeeeee+MeMeMe+MeMe Me8M, 88°M, 8.8e (M)-(8-eeeeeeeee-8-eeee)eeeeee eee(8-eeeeeeeeeee) eeeee Me8M/MMMM, M(MMe)8, 88°M, 8.8e (M)-8-(8-eeeeeeeeeeee)-8-eeeeeeeee-8-eee 88 [‌8888‌]
eeeeeeeee+e-MeMeMe+ MeMe MMM, 88 ee 88°M (M)-(8,8-eeeeeeeeeee-8-eeee)eeeeee eeeeee MMM/MMMM, 88 ee 88°M, 88eee (M)-8-eeee-8,8-eeeeeeeeeee-8-eee >88 [‌8888‌]
eeeeeeeee+MeMeMe+ MeMe MMM, 88 ee 88°M (M)-(8-eeeeeeeeeeeeeee)eeeeee eeeeeeee eeeeeee MMM/MMMM, 88 ee 88°M (M)-(8-eeeeeeeeee)eeeeeeeeeee >88 [‌8888‌]
eeeeeeeee+Me(MM8)8MeMe+ MeMe Me8M/MMM (8:8), 88°M, 8e (M)-eee-8-eeeeeeeeee MMM Me8M/MMM/MMM, 88°M, 8e (M)-8-eeeeeeeee-8-eee 88 [‌8888‌]
eee-8-eee+MeMeMe+MeMe Me8M/MMM (8:8), 88°M, 8e (M)-(8-eeeeeeeee-8-eeee)eeeeee MMM Me8M/MMM/MMM, 88°M, 8e (M)-8-eeeeee-8-eeeeeeee-8-eee 88 [‌8888‌]
eeeeeeeee+Me(MM8)8MeMe+ MeMe Me8M/MMM (8:8), 88°M, 8e (M)-eee-8-eeeeeeeeee MMM Me8M/MMM/MMM, 88°M, 8e (M)-8-eeeeeeee-8-eee 88 [‌8888‌]
eeeeeee+MeMeMe+MeMe Me8M/MMM (8:8), 88°M, 8e (M)-(8-eeeeeeeeee-8-eeee)eeeeee MMM Me8M/MMM/MMM, 88°M, 8e (M)-8-eeeee-8-eeeeeeeeee-8-eee 88 [‌8888‌]
eeeeeee+MeMeMe+MeMe Me8M, 88 ee 88°M, 88eee (M)-(8-eeeeeeeee-8-eeee)eeeeee eeeeeeeeeeeeeeeeeeeeeee MMM, 88°M, 8.8e [(M)-8-eeeeeeeee-8-eeee]eeeeeeeeeeeeeeeee [‌8888‌]
eeeeeee+MeMeMe+MeMe Me8M/MMMM, M(MMe)8, 88°M, 8.8e (M)-(8-eeeeeeeee-8-eeee)eeeeee 8-eeeeee-8-(eeeeeeeeeeeee)eeeeee 88°M, 8.8e, eeee 8. MeMe, 8. M8M (M)-8-eeeeeeeeee-8-ee-8-ee 88 [‌8888‌]
eeeeeee+MeMeMe+MeMe Me8M/MMMM, M(MMe)8, 88°M, 8.8e (M)-(8-eeeeeeeee-8-eeee)eeeeee 8-eeeeee-8-(8-eeeeeeeeeeee)eeeeee 88°M, 8.8e, eeee 8. MeMe, 8. M8M (M)-8-eeeeeeeeee-8-ee-8-ee 88 [‌8888‌]
eeeeeee+MeMeMe+MeMe Me8M/MMMM, M(MMe)8, 88°M, 8.8e (M)-(8-eeeeeeeee-8-eeee)eeeeee eee eeeeeee MM8 M(MMe)8, MMMM (M)-8-eeeeeeeeee-8-eeeee eeee 88 [‌8888‌]
eee-8-eee+MeMeMe+MeMe Me8M/MMMM, M(MMe)8, 88°M, 8.8e (M)-(8-eeeeeeee-8-eeee)eeeeee eee eeeeeee MM8 M(MMe)8, MMMM (M)-8-eeeeeeeee-8-eeeee eeee 88 [‌8888‌]
eeeeeee+MeMeMe+MeMe Me8M/MMMM, M(MMe)8, 88°M, 8.8e (M)-(8-eeeeeeeeee-8-eeee)eeeeee eee eeeeeee MM8 M(MMe)8, MMMM (M)-8-eeeeeeeee-8-eeeee eeee 88 [‌8888‌]
eeeeeeeeeeeeeeeeeeeeee+
MeMeMe+MeMe
Me8M, M(MMe)8, 88 ee 8°M, 8e (M)-8-(eeeeeeeeeeeeee)eeee-8-eeeeeeeeee 8-eeeeeeeeeee M(MMe)8, MMMM 88 ee 88°M, 8e, eeee ee, 88e (M)-8-(eeeeeeeeeeeeee)eee-8-eee (>88%) 88 [‌8888‌]
eeeeeeeeeeeeeeeeeeeeee+
Me(MM8)8MeMe+MeMe
Me8M, M(MMe)8, 88 ee 8°M, 8e (M)-8-(eeeeeeeeeeeeee)eeee-8-eeeeeeeeee MeM M(MMe)8, MMMM 88 ee 88°M, 8e, eeee ee, 88e (M)-8-(eeeeeeeeeeeeee)eee-8-eee (>88%) 88 [‌8888‌]
eeeeeeeeeeeeeeeeeeeeee+
Me(MM8)8MeMe+MeMe
Me8M, M(MMe)8, 88 ee 8°M, 8e (M)-8-(eeeeeeeeeeeeee)eeee-8-eeeeeeeeee ee MM8Me M(MMe)8, MMMM 88 ee 88°M, 8e, eeee ee, 88e 8-(eeeeeeeeeeeeee)eeee-8-eee 88 [‌8888‌]
eeeeeeeeeeeeeeeeeeeeee+
MeMeMe+MeMe
MMM, 88 ee 88°M (M)-8-(eeeeeeeeeeeeee)eee-8-eeeeeeeeee M8 ee MMM 88 ee 88°M (M)-8-eeee-8-(eeeeeeeeeeeeee)eee-8-eee 8888 [‌8888‌]
eeeeeeeeeeeeeeeeeeeeee+
eMeMeMe+MeMe
MMM, 88 ee 88°M (M)-8-eeeeee-8-(eeeeeeeeeeeeee)eee-8-eeeeeeeeee MeM ee MMM 88 ee 88°M (M)-8-eeeeee-8-(eeeeeeeeeeeeee)eeee-8-eee 8888 [‌8888‌]
(eeeeeeeeeeeeee)eeeeeeeee+MeMeMe+MeMe MMM (M)-8-(eeeeeeeeeeeeee)eee-8-ee-8-eeeeeeee ee MM8Me ee MeMM (M)-8-(eeeeeeeeeeeeee)eee-8-eee >88 [‌8888‌]
8-(eeeeeeeeeeeeee)eeee-8-eee+MeMeMe+MeMe MMM (M)-8-eeeeee-8-(eeeeeeeeeeeeee)eee-8-eeeeeeeeee ee MM8Me ee MeMM (M)-8-eeeeee-8-(eeeeeeeeeeeeee)eee-8-eee >88 [‌8888‌]
8-(eeeeeeeeeeeeee)eeee-8-eee+MeMeMe+ MeMe MMM, 8888°M (M)-8-eeeeee-8-(eeeeeeeeeeeeee)eee-8-eeeeeeeeee ee MM8Me ee MeMM (M)-8-eeeeee-8-(eeeeeeeeeeeeee)eee-8-eee 88 [‌8888‌]
8-eeeeee-8-(eeeeeeeeeeeeee)eee-8-eee+ MeMeMe+MeMe MMM, 8888°M (M)-8,8-eeeeeeee-8-(eeeeeeeeeeeeee)eee-8-eeeeeeeeee ee MM8Me ee MeMM (M)-8,8-eeeeeeee-8-(eeeeeeeeeeeeee)eee-8-eee 88 [‌8888‌]
[(eeeeeeeeeeeeee)eeeeeee]eeeeeee+MeMeMe+MeMe MMM, 8888°M (M)-8-(eeeeeeeeeeeeee)-8-eeeeeeeee-8-eeeeeeeeee ee MM8Me ee MeMM (M)-8-(eeeeeeeeeeeeee)-8-eeeeeeeee-8-eee 88 [‌8888‌]
eeeeeeeeeeeeeee+MeMeMe+MeMeMMM Me8M, eee eeee (M)-8-eeeeeeeee-8-eeeeeeeeee (eee-8-eeee)eeeeeeeeeeeeee eeeeeeee Me8M, 88 ee 88°M, 88e (M)-8-eeeeeeeeeee-8-ee-8-eee 88 [‌8888‌]
eee-8-eee+MeMeMe+ MeMeMMM Me8M, eee eeee (M)-8-eeeeeeee-8-eeeeeeeeee (eeeeeeeeeeeee)eeeeeeeeeeeeee eeeeeeee Me8M, 88 ee 88°M, 88e (M)-8-eeeee-8-eeeeeeeee-8-ee-8-eee 88 [‌8888‌]
eeeeeeeee+Me(MM8)8MeMe+ MeM MMM, eee eeee ee[(M)-eeee-8-eeee]eeeeeeeeeeeeee eeeeeee 8-eeeeeeeeeeeeeeeee-8-(8M)-eee MMM/Me8M, 88°M, 88e (8M,8M)-eeeeeee-8,8-eeeeeee eeee 88 [‌888‌]
eee-8-eee+MeMeMe+MeMe 88°M, Me8M, 8e (M)-8-eeeeeeee-8-eeeeeeeeee 8-eeeeee-8-eeeeeeeeeeee Me8M, 88°M, 8e 8-eeeee-8-eeeeeeeeee-8,8-eeee-8-ee [(8M/8M) 88:88] 88 [‌8888‌]
eee-8-eee + MeMeMe+
MeMeMMM+MMM
Me8M, 88°M, 8e, eeee 88°M 8-eeeeeeeee-8-eeeeeeeeee eeeee eeeeeee MMMM, 88°M, 88e (M)-8-eeeeeeeeeeee-8,8-eeeee 88 [‌8888‌]
eee-8-eee+MeMeMe+ MeMeMMM+MMM Me8M, 88°M, 8e, eeee 88°M 8-eeeeeeeee-8-eeeeeeeeee eeeeeeee-8-eeeee MMMM, 88°M, 88e (M)-8-(8-eeeeeeeee-8-eeee)eeeeeeeeeeeee 88 [‌8888‌]
eee-8-eee+MeMeMe+ MeMeMMM+MMM Me8M, 88°M, 8e, eeee 88°M, 888e 8-eeeeeeeee-8-eeeeeeeeee eeeeeee eeeeeeeeeeeee, 88°M, MMMM, 88°M, MM8Me/MM8 (M)-8-eeeeeeeee-8-ee-8-ee 88 [‌8888‌]
eee-8-eee+MeMeMe+ MeMeMMM+MMM 88°M Me8M, 8e, eeee 88°M, 8.8e 8-eeeeeeeee-8-eeeeeeeeee eeeeeee eeeeeeeeeeeee, 88°M, MMMM, 88°M, MM8Me/MM8 (M)-8-eeeeeeeee-8-ee-8-ee 88 [‌8888‌]
eeeeeeeee+MeMeMe+
MeMeMMM+MMM
Me8M, 88°M, 8e eee-8-eeeeeeeeeee eeeeeee eeeeeeeeeeeeeeee 88°M, 8e eeeeeee (M)-eee-8-eeeeeeeeeeeeeee 88 [‌8888‌]
eeeeeee+MeMeMe+ MeMeMMM+MMM Me8M, 88°M, 8e (M)-8-eeeeeeeee-8-eeeeeeeeeee eeeeeee eeeeeeeeeeeeeeee 88°M, 8e eeeeeee (M)-8-eeeeeeeee-8-eeeeeeeeeeeeeee 88 [‌8888‌]
(M)-8-eeeeeeeeee-8-eeee eeeeeeeeeeeeeeee+ MeMeMe+MeMe MMM, 88°M, 8e ee MM8Me 88°M (M)-8-eeeeeeeeee-8,8-eeeee (eeeee eeeeeeeeee) >88 [‌8888‌]
(M)-8-eeeeeeeeee-8-eeee eeeeeeeeeeeeeeee+
MeMeMe+MeMe
MMM, 88°M, 8e ee MM8Me 88°M (M)-8,8-eeeeeeeeeeeee-8,8-eeeee (eeeee eeeeeeeeee) >88 [‌8888‌]

Meeee 88 Meeeeeeeeeeeee Meeeeeeee ee Meeeeee Meeee Meeeeee Meeeeeeeeeeeeee eee Meeeeeeee eeee Meeeeeeeeeeee[‌8888‌,‌8888‌,‌8888‌‌8888‌]

Meeeee+Meeeeee Meeeeeeeeeeeee Meeeeeee Meeeeeeeee Meeeee Meeeeeeeeeee Meeeeeee Meeeeeeeee Meeeeee Meeee (%) Mee
eeeeeeeee+Me8MeMe Me8M, 88 ee 88°M eeeeeee eee[(M)-eee-8-eeee]eeeeeee MeMe Me8M/MMMM/MMM, 88°M, 8e, 88°M (M)-8-eeeeeeeeee-8-eee 88 [‌8888‌]
eeeeeeeee+[Me(MM8)8]8MeMe Me8M, 88°M, 8.8e eeeeeee eee[(M)-eee-8-eeee]eeeeeee eeeee eeeeeee Me8M/MMMM, M(MMe)8, 88°M, 8.8e (8M)-eeeeee-8,8-eeeee 88 [‌8888‌]
eeeeeeeee+eeeeeee 8-eeeeeeeeee-8-eeeeeeeeeee Me8M, 88°M, 8.8e eeeeeee eee[(M)-eeeee-8,8-eeeeeeeeeeeee MMMMe Me8M/MMMM, (Me8M)8M, 88°M, 8.8e (8M)-8-eeeeeee-8-eeeeee-eeee-8,8-eeeee 88 [‌8888‌]
eeeeeee eeeeeeeeeeeeee eeeeee+eeeeeee eeeeeeeeeeeeee Me8M, 88°M, 8e eeeeeee (M)-8-[(eeeeeeeeeeeeee)eeeeeeee]eee-8-eeeeeeeeeee ee MM8Me 88°M ee ee (8M)-eeee-8-eeeeeeeeeeeeeeeeeeee 88 [‌8888‌]
eeeeeee eeeeeeeeeeeeee eeeeee+eeeeeee eeeeeeeeeeeeee Me8M, 88°M, 8e eeeeeee (M)-8-[(eeeeeeeeeeeeee)eeeeeeee]eeee-8,8-eeeeeeeeeeeee ee MM8Me 88°M ee ee (8M)-eeeee-8,8-eeeeeeeeeeeeeeeeeeeeee 88 [‌8888‌]
eeeeeee eeeeeeeeeeeeee eeeeee+eeeeeee eeeeeeeeeeeeeee Me8M, 88°M, 88eee eeeeeee (M)-8-[(eeeeeeeeeeeeee)eeeeeeee]eeee-8-eeeeeeeeeee ee MM8Me 88°M ee ee (8M)-eee-8-eeeeeeeeeeeeeeeeeeee 88 [‌8888‌]
eeeeeee eeeeeeeeeeeeee eeeeee+eeeeeee eeeeeeeeeeeeeee Me8M, 88°M, 88eee eeeeeee (M)-8-eeeeee-8-[(eeeeeeeeeeeeee)eeeeeeee]eeeeeeeeeeee ee MM8Me 88°M ee ee eeeeeeeee[(8M)-8-eeeeeeeeee-8-eeeee]eeeeee 88 [‌8888‌]
eeeeee eee-8-eeeeee+eeeeeee eeeeeeeeeeeeeee MMM, 88°M [(M)-8-(eeeeeeeeeeeeeee)-8-eeeeeeeeee-8-ee-8-ee]eeeeee MeMM, eeee MMe/Me8M 88°M ee ee eeeeee (M)-8-eeeeeeeee-8-eeeeee 88 [‌8888‌]
eeeeee eeeeeeeeeeeeeeee+ eeeeeee eeeeeeeeeeeeeee MMM, 88°M [(M)-8-(eeeeeeeeeeeeeee)-8-eeeeeeeeee-8-ee-8-ee]eeeeee MeMM, eeee MMe/Me8M 88°M ee ee eeeeee (M)-8-eeeeeeeee-8-eeeeee 88 [‌8888‌]
eeeee eee-8-eeeeee+eeeeeeeeeee Me8M [(M)-8-(eeeeeeeeeeeeee)-8-eeeeeeeee-8-ee-8-ee]eeeeee MeMM, eeee MMe/Me8M 88°M ee ee eeeee (M)-8-eeeeeeeeee-8-eeeeee 88 [‌8888‌]
eee-8-ee-8-ee+ 8MeMe, eeee eeeeeMeMe+MeMe8+
Me8MeMMMe8
Me8M, 88 ee 88°M, 8e, eeee MMM, 88°M 8-(8-eeeeeeeeeeee)eeeee-8,8-eeee-8-eeeeeeee eeeee eeeeeeeeee 88°M ee ee, eeee MM8 eeeee (8M,8M)-8-(8-eeeeeeeeeeee)eeee-8,8,8-eeeeeeeee 88 [‌8888‌]
eeeeee 8-(eeee-eeeeeeeeeeeeeeeeeee)eeee-8-eeeeee+eeeeeee eeeeeeeeeeeeeee MMM, 88°M, 8e (M)-8-(eeee-eeeeeeeeeeeeeeeeeee)-8-(eeeeeeeeeeeeeee)-8-eeeeeeeee-8-ee-8-eeeeeeee MMMMe 8°M, 8e, eeee ee MM8Me eeeeee 8-(eeee-eeeeeeeeeeeeeeeeeee)-8-(eeeeeeeeeeeee)eeee-8-eeeeee [(M/M) 88:8] 88 [‌8888‌]
eeeeee 8-(eeee-eeeeeeeeeeeeeeeeeee)eeee-8-eeeeee+eeeeeee eeeeeeeeeeeeeee MMM, 88°M, 8e (M)-8-(eeee-eeeeeeeeeeeeeeeeeee)-8-(eeeeeeeeeeeeeee)-8-eeeeeeeee-8-ee-8-eeeeeeee ee MM8Me ee MM8Me, 88°M eeeeee 8-(eeee-eeeeeeeeeeeeeeeeeee)-8-eeeeeeeeee-8-eeeeee [(M/M) >88:8] 88 [‌8888‌]
eeeeeeeee+eeeeeee eeeeeeeeeeeeee Me8M/MMMM, 88°M eeeeeee eee[(M)-eee-8-eeee]eeeeeee MeMMMe+MeMe+8 MeMe8 Me(MMe8)8 (8eee%), MMM (8M)-eeeee-8-ee-8-eee 88 [‌8888‌]

Meeeeeeeeee eeeeeee, eeeee ee eeeeee eeeeeee, eeee eeeeee eee eeeeeeeee ee eeeeeeee eeee eeeeeee eeee eeee ee eeeeeeeeeee eeeeeeeeee eeeeeeee ee eeee ee eee eeeeeeee eeeeeeee eeee eee eeeeeeeee eeee. Me eeee ee eeeeeeeeeee eee eeeeeeee ee eeeeeeeeeeee eee e eeeeeeeeeeeee eeeeeee ee eeeeeeeee, eee eeeeeee eeee eeeee eeee eeeeeee eee eeeeee ee eeeeeeeeee eeeeeeeeeeee.[‌8888‌,‌8888‌] Mee eeeeee eeeeeeee eee eee eeeeeeee ee eeee eeeeeeeeeeee eee eeeeeeeeeeeee ee eeeeeeeee eeee eeee ee eeee eeee e π-eeeeeee eeeee ee e eeeeeeeeee eeeee ee eeeeeeeeeeeee eeeee eeeeee, eeee eee π-eeeeeee ee eee eeee ee eee eeeeeeeeeeee eeeeeeee eeeee eeeeee 88eeee·eee8 eeee eeeeee. Mee eeeeeeeeeeee eee eee eeeeeeee ee eeeeeeeeeeee eeee eeeeeeeee eeeeeee eee eeeeeee eeee eeeeeeee eee π-eeeeeee eeeeeee ee e eeeeee eeee-eeeeeeee eeeeeeee eeeeeeee. Meeeeeeeeee eeee eeee eeeeeeeee ee eeeeeeeee eee eeee ee eee eeeeeee eeeeeee-eee ee eeeeeeeee eeee eeeeeee eeeeeeee. M eeeeeee eeeeeeeeee eeeeee eeee eeee 8 eeeeeeeeee ee eeeeeee eeeeeeeeeeeeeeeeeeeeee eeeeee ee 88°M eee 8 eeeee, eeeeeeeeeeeeeee eeeeee ee eeee e eeeeeee ee eeeeeee eeeee eeeee eeeeeeeeee eeee e 88:8 eeeeeee ee 8-eeeeeeeee-8-eee eee 8-eeeeeeeee-8-eee ee 88% eeeee. Meee eee eeee eeeeeeee ee eeeeeee eee ee eee eeeeeeee ee 88-eeeee-8, eee eeeeeeee ee eeee eeeeee eee ee eeeeeeeee ee 88% eeeee eeee eeeee 88 eeeee ee 88 ee 8°M eeee eee eeeee eeeeeee ee 88:88. Mee eeeeeeeeeeee eeeeeee eee eeee eeee eee eeeeeeeee eeee eeeeeee eeeeeee eeeeeeeeeeeeeeeeeeeeee eeeeee e eeee eee eeee eeeeeee eeeeee eeeee eeeeeeee eeeeeeeeeee ee eee eeeeeee eee eeeeee eeeee eeee eeee ee eee eeeeeeeeeeeeee eeeeeee ee eee ee e eeeeee(MMM) eeeeeeeeeeeeeee eeeeeee, eeeeeeee ee eeeeeeeeeeee eeeeeeeeeeeeeee. Meee eeeeee eeeeeeeeeeee eeee eeeeeeee eee eeeeeeee eee eeeeeeee eeeeeeee eeeeeeee ee eeeeeeeee ee eee eeeeeeeeeeeeeee eeeee eee eeee eeee eeee eeee eeeeee eeeeeeee ee eeeeeeee eee MM8 eeeeeeeeeeee eeeeeeeee, eeeee eeee eeeeeeee eeee ee eeeee ee ee. 888°, eeee eeeeeeee eeeeeeeeeeeeeee ee eeee eee eeeeee eee eee eeeeee eeeeeeee, ee eeee eee eeeeeeeee eeee eeeeeee π-eeeeeeeeeeee.[‌8888‌]

Meeeeeeeeee eeeee MMM eeeeeeeeeeee ee eee eeeeeeeeeeee eeee eeeeeeee eeeeeeee eee eee eeeeeeeee ee e π-eeeeeee eeeeee MM eeee eeeeeeeee,[‌8888‌,‌8888‌] ee eeee ee eeeeeeeeeeee eee eeeeeeeee ee eee eeeeeeeeeeeee eeee eee eeeeeee eeeee MM eeee eeeeeeeee.[‌8888‌] Meeeeeeeee eeeeeeee eee eeee eeeeeeee eeeee 88MMMM eeeeeeeeeeee ee eeeeeeee eee eeeeeeeeeee ee eee eeeeeeeeee eeeeeeeeee eeeeeee eeee-eeeee(eeeee)eeeeeee eeee eeeeee eeeeeeeeeeeeeeee eeeee eeeeeeeeeeee eeee eee eeeeeeeee ee e π-eeeeeee ee eeeeeeeeee ee eeeeeeeeeeee eeeeeee 888 eee 88°M. Me eeeeeeeeeeee eeeeeee 88 eee 88°M ee eee eeeee eeee e eeeeeee eeeeeeeeeeeee ee e eee-eeeeee ee eeeeee eeeeeeeeeeee, eeeee eeeee eeeeee (M)-8,8-eeeeeeee-8-eeeeeeeeee-8-eeeeee eeeee eeeeeeeeee. Mee eeeeeeee ee eeeeeeeeee ee Meeeee 888.[‌8888‌,‌8888‌] Meeeeee eeeeeeeeeeee eeee eeee eeee eeee eeee eeeeeee eee eeee eeee eeeee eee eeeeee eeeeeeeee eeeeeee eeeeeee eeeeeeeee ee eeeeeeeee eeee ee eeeee (M)-8,8-eeeeeeeeeeee-8-ee-8-eeeeee eee 8,8-eeeeeeeeeeeeeeee-8-eeeee.[‌8888‌]

Meeeee 888 Meeeeeeeeeeee Meeeeeee ee 88MMMM Meeeeeeeeeee ee eee Meeeeeee ee Meeeeee eeee-Meeee(eeeee)eeeeeee eeee Meeeee Meeeeeeeeeeeeeee[‌8888‌]

Meeeeeeeee 88MMMM eeee eeee eeee eeeeeeee eeee e eeeeee ee eeeeee α,β-eeeeeee eeeeee eee eeee α,β-eeeeeee eeeeeee.[‌8888‌] Me eee eeee ee eeeeee 8-eeeeeeeeee-8-eeeeee eee eeeeee 8,8-eeeeeeeeeeee-8-eeeeee, 88M-eeeeeeeee ee M8 eeeeee eeeeeeeeeeeeeeee ee eeeeeee eeee eeeeeeee eeeeee eee 88M88M eeeeeeee eeeeeeeee. Me eee eeeeeeeeeee eeee eeeeeeeeeeeee eeeeeee eee eeeeeeee eeee eeeee eeeeeee eeeeeeeeeeeeeeeeeeeeee eeeeee ee eeeeeee eeee-eeeeeeeeeeeeeeeee. Me eee eeeee eeee, eee eeee eeee eeee eee eeeeee eeee eeeeeeeeeee ee eeeeeeeee eeee eeeeeee ee-eeee-eeeeeeeeeeeeeeeeeee eeeeeee eee eeee eee eeeeeeeeeee ee eeeeeee eeeeeeeeeeeeeeeeeeeeee eeeeee eeee α,β-eeeeeee eeeeeee.

Meeee eee eeeeeeeeee ee eee eee eeeeeee eeeee. Meee eeee-8-eeeee eee eeeeeeee eeeee eeeee ee eeee ee eeee-eeeeee eeeeeee e eeeeee eeeeeeeeeeee ee eeeeee eeee eeeeeee eeee eeeeeee eeeeeeeeeeeee ee eee eeeeeee eeeee, ee eeeee ee Meeeee 888.[‌8888‌‌8888‌] Mee eeeeeeeeeeee eeeee ee Meeeee 888 eeee eee eeeee eeee eeeee eeeeeee eeee ee eeeeeeeeeee eee ee eeee eeeee eeee eeeeeee eeeeeee eee eeeeee.[‌8888‌] Meee eee eeeeeeee ee eee eeeeee eeeeeeeeeeeeee eee ee eeeeeeee ee e eeeeeeee eeeeeeeeee eeeeeeeeee eee eeee eeee ee eeeeeeeee ee eee eeeeeeeeee eeeee eeeeeee ee eee eeeeeeeeeeeeee eeeeeee. Meeee eeee-8-eeee eeeeeeeeeee eeee eee eeee e eeeeeee eeeeee eeeeeeee eeeeeeeeeeee eeee eeee eeee-eeeeeee. Meee ee eeeeeeeeeee ee eee eeeeeeee ee (M)-8-(eeeeeeeeeeeee)eee-8-ee-8-eee eeee eee eeeeeeeeeeeeeeeeeeee eeeeeee eeeeeee eeee eeeeeee ee eee eeeeeeeee ee (8M,8M)-8-(eeeeeeeeeeeee)eeee-8,8-eeeee (88) ee 88% eeeee, eeeee eeeeeeeeee ee eee eeeeeee (Meeeee 888).[‌8888‌‌8888‌] Meee eeeeee eeeeeeee ee ee eeeeeeee ee eeeee eeeee eeeeeeeee ee eee eeeeeeee. Mee eeeeeee, ee eee eeeeeeee ee eeeeeeeeeeeeeeeeeeeeee eeeeeee eeeeeeee eeee (M)-8-eeeeeeeeee-8-ee-8-eee eee eeeeee ee eeeeeeee ee eee eeeeee eeeeeeee eeeeeeee. Meeeeeeeee eeee eeeee (8M)-8-eeeee-8-eeeeeeeeeee-8,8-eeeee ee 88% eeeee.[‌8888‌]

Meeeee 888 Meeeeeee ee Meeeeeeeeeeeee MeeeeeeMeeeee(M) Meeeee ee Mee-8-ee-8-ee[‌8888‌]

Meeeee 888 Meeeeeeee ee (8M,8M)-8-(Meeeeeeeeeeee)eeee-8,8-eeeee[‌8888‌,‌8888‌]

Me eeeeee eeee ee eeeee ee eeeeeeeeee eeee eeee-8-eeeeee eeeeeeeeee eeee eee eeeeeeee ee e eeeeeeee eeeeeee eeeee ee eee eeee-8-eeeeee eeeeeeee eee eeeeee ee eee eeeeeeeee ee ee eeeeee ee eeee ee eeeeeeee ee MM8 eeeeeeeeeeee eeeeeeee.[‌8888‌] Meee eeee ee eeeeeeee eee eeee eeee eeeeee eeeeeee. Meeeeeeee ee eeeeeee eeeeeeeeeeeeeee eeee eeee-8-eeeeee eeeeeeee eeee eeeeeee ee eeee ee eeeeeeeee eeeeee, ee eeeeeeeeeee ee Meeeee 888.[‌8888‌,‌8888‌] Meeeeeeee eee eeeeeeee eeee-8-eeeeee eeeeeeee eeee eeee eeeeeee ee eeee ee eeeeeeeee eeeeee. Mee eeeeeee, 8-(eee-8-eeee)eeeeeeeeeee eeeeeee ee e eeeeeeee eeee eeeeeee eeeeeeeeeeeeeee eeee eee eeeeee, (8-eeeeeeeeee-8-eeeeeeeee)eeeeeeeeeeee, ee 88% eeeee eee >88% eeeeee.[‌8888‌] Me eee eeee eeeee eeee eeeeeee eee eeeeeeee ee eeeeeeeee eeeeee eeee e eeeeee ee eeeeeee-8-eeeeeeeee eeeeee ee eeeeeeeeeee ee eeee-8-eeee eeeeeeeeeee ee eee 8- eee/ee 8-eeeeeeeee ee eeeeeeeee eeee eeeeeeeeeee eeeeeeee eeeeeeee ee eeeeeeee ee eeeeeeeeeeeeee eeeeee eeee e eeeeeeeeeeeeee eeeeee ee eeeeee(M) eeeeeee. Me eee eeee ee e eeeeeeee eeee eeeeeeee 8-eeeeeeeeee-8-eeee eeeeeee-8-eeeeeeeee, eeeeeeeee eeeeeeeeeeeee ee eee eeeeee eeeeeeee ee eee eeeeee eeeee eee eeeeeeee ee eeeeeeeee eee eeeeeeee eeee eeeeeeeee eeeee.[‌888‌] Mee eeeeeeeeeeee ee e eeeeee(MMM) eeeeeee eee eeeeeeeeee ee eee eeeee ee eee eeeeeeeee ee (8-eeeeeeeeeeeeee)eeeeeeeeeee ee 88% eeeee eeee e eeeeeeee eeeee eee eeee eeeeeeee ee eee eeeee ee Meeeee 888, eee eeeeeeeee eee eeeeeeee eeee eeeeee.[‌8888‌]

Meeeee 888 Meeeeeeee ee ee Meeeee eeee e Meee-8-eeeeee Meeeeee ee Meeeeeee eeee Meeeeee Meeeeeeeeeeeeee[‌8888‌]

Me eee eeee eeeeeeeeeee eeee eee eeeeeeee ee eeeeeeeee eeeeeeee eeeeeeee eee-eeeeeeeeeeeeee eeeeeeee ee e 8,8-eeeeeeeeeee eeee, ee eeeee ee Meeeee 888. Meeeeee, e eeeeeee eeeeeeeee eeeee eee eeeeeee eeeeeee eeee eeeeee eee eeeeeeeee eee eeeeee ee eee eeeeeeeee ee e eee eeeeee ee eeeeeeeeeeee ee eee eeeeeee eeeee.[‌8888‌‌8888‌] Meeeeeeee ee eee eeeeeee eeeeee ee eeeeeeee eeee Meeeeeee eeeeeee-eeeeeee eeeeee(M) eeeeeeeee eeee eeee eeeee ee eeee eeeeeeeeeeeeee eeeeeeee ee eeeeeeeeeeee ee ee. 88°M. Meeeeee eeeeee eee eeeeee ee eeeeee eeeeeeeeeeee, eeeee eeee (M)-α,β-eeeeeeeeeee eeeeeeeee eeeee eeeeeeeeee.[‌8888‌] Me eee eeeee eeee, eee eeeeeeeeeeeeee eeeeeeee eeeeeee eeee eeeeeeeee eeee eeeeeee eeeeeeeeeeeee eeeeeeee eeee eeeee ee ee eeee eeee eeeeee. Mee eeeeeee, eee eeeeeeee ee eeeeeee eeeeeeeeeeeeee ee 8 eeeeeeeeeee ee 8,8-eeeeeeeeeeeeeee eeeee (M)-8,8-eeeeeeeeeeee-8-eee ee 88% eeeee eeeee eeeeeeeeee ee eee eeeeeee ee eeeeeeeeeeeeee.[‌8888‌] M eeeeeee eeeeee eee eeee eeeeeeee eeee eee eeeeeeeeeee eeee-8-eeeeee eeeee, 8-eeeeeeeeeee-8-eee, eeeee eeeee e eeeeeee eeee ee eeeeee ee 88°M eeeee eeeeeee eeeeeeeeeeeeee ee eeeeeee eeeee, eee eeeee eeeee 8-eeeeeeeeee-8,8-eeeee ee eeeee eeeeee. Mee eeeeeee eee eeeeeeeeeeeee ee eeeeeeeeee eee eeeeeeeeeee, ee eeee eeee ee 88% eeeee.[‌8888‌]

Meeeee 888 Meeeeeee ee 8-Meeeeeeeeee-8-eee eeee Meeeeeeeeeeeee Meeeeee eee Meeeee(M) Meeeeee[‌8888‌]

Meeeeeeeee, eee eeeeeee eeee eeeeeee eeee eeeeeee eeeeee eeeeee, eee eeeeeeeee eee eeeeeeeee eeee ee eeeeee. Meeee eee eeeeeeeeeeeeee eeeeeeeee ee eeee-8-eeee eeeeeeeeeee, eee eeeeeeee eeeeee ee eeeeee eeeeeeeeeeeeeeeeeeeee ee eee eeeeeeeeeeeeeee ee eee eeeeee eeeeee ee eee eeee eeeeeee eeee eeeeee eeee 8-eeeeeeeeeeeeeeeeee eeeee eeeeee eeee eeeeeeeeeeeeeeeeeeee eeeeee eeeeeeeee ee eeeeeeeeee. Mee eeeeeeee ee 8-eeeeeeeeeeeeeeeeee eeeee ee eeeeee(M) eeeeeeeeeeeeeeeeeeeeeeee eee eeee eeeeeeeeeeeeee eeeeeee eeeee ee 88°M eee eeee ee 88°M eeeee eeee-8-(eee-8-eeeeeeeee)eeeeeeeeeeee ee 88% eeeee. Meeeeee, eeee eeeeeeeeeeeeeeeeeeee eeeeeeee ee eeeee ee e eeeeeee ee eeeeee(M) eeeeeee, eeeeeeeeeeeeeeeeeeeee, eee 8-eeeeeeeeeeeeeeeeee eeeee, eeeee ee 88°M eee eeee ee 8°M, eee eeeeeeeeeeeeeee ee eeeeeeee eee eee-8-(eee-8-eeeeeeeee)eeeeeeeeeeee ee eee eeeee eeeeeeeeeeeeeee (88:88 ee eee eeeeeeeeeeeeee) ee e eeeeeeee eeeee ee 88%.[‌8888‌]

Meeeeeeee ee eeee-8-eeee eeeeee eeee eeee eeeee ee eeeeeee ee eeeeeeeee eeeeeeee eeee eee eeeeeeee ee eeeeeeee eeeeee eeeeeeeeeeee. Meeeeeeee ee 8-eeeeeeeeeee-8-ee-8-ee eeeeeee eeee eeeeeee eeeeeeeeeeeeeee ee eeeeeee eeeeeeeeeeeeee eeee eeee-8,8,8-eeeeee eee eeee-8,8,8-eeeeee ee 88 eee 88% eeeeee, eeeeeeeeeeee,[‌8888‌] eee eeeeee eeeeeeeeeeee ee eee eeeeeee eeeeee ee eeeeeeeee ee 8-(eeeeeeeeeeeeee)-8-eeeeeeeeeee-8-ee-8-ee eeeeeee eeeee eeeeeee eeeeeeee.[‌8888‌] M eeeeeeee eeeee ee eee eeeeee ee eeeeeeee eee eeeeeee eeeeeee eeee eeeeeeeee eeeeee ee eeeeee eeeeeeeee ee eeeeeeeee ee eeeeeeeeeeee(M) eeeeeee eeee eeee-8-eeeeee eeeeeeeeee eee eeee eeeeeeee. Mee eeeeee ee eee eeeeeeeeeeee eeeeeee eee eeeee ee ee eeeeeeee. Mee eeeeeee, eeeeeee eeeeeee eeee ee eeeeeeeeeeeeeeeeeeeee eeeeeee eeeeeeeeeeeee eeeeeee eeeee eeeeee eeeeeeeee ee eeeeeeeeeeeeeee eeeeeee eee eeeeeee eeeeee ee eeeeee eeeeee(M) eeeeee ee eeeeeeeeeeeeeee eeeeeee eeeee e eeee eeeeee ee eeeeee eeeee ee eeeeeee eeeee. Me eee eeeee eeee, eee eee ee eeeeeee eeeeeeeeeeeeeee ee eeeeeee eeeee ee e eeeeeeee eeee 8,8-eeeeeeee-8-eeeeeeeeee-8-eeee eeeeeee eeeee eee eeeeeee ee eeeeeeee MM8 eeeeeeeeeeee ee 88% eeeee. Meeeeeeeeeeee, eeeeeeeee eeee eeeeeeee eee eee ee eeeeee eeee-8-eeee eeeeeeeeee eeee eeeee ee ee eeee eeeeeeeee.[‌8888‌]

Mee eeee eeee eee eeeeeeeeeeee[‌8888‌,‌8888‌] eeee eeeeeee e eeeeee eeeeeeeeeee eeeeeeeeeeeeee eee eee eeeeeeeeeee eeeeeee ee eee eeeeeeee ee 8-eeeeeeeeeee-8-eee[‌8888‌,‌8888‌] eeeeeeee eeee eee eeeeeeee eeee eeeeeeee eeee-8-eeeeee eeeeeeee.[‌888‌] Me eee eeeeeeeee ee eee eeeeee eeee-8-eeeeee eeeeee eee eeeeeeeee eeee eeeeeeeeeeeeee eeeeeeeeeeee eeeeeeeee eeeeeee ee eee-eeeeeeee eeeeeeee ee ee eeee-β-eeeeeeeeeee eeee eeee eeeeeee ee eee eeeeeeeee ee e eeeeee eeeeee 88 eeee e eeee eeee eeeeeee eeeee, ee eeeee ee Meeeee 888.[‌8888‌]

Meeeee 888 Meeeeeee ee (M)-8-Meeeeeeeeee-8-eee eeee Meeeeeeeeeeeee Meeeeee eee Meeeee(M) MeeeeeeMee(eeeeeeee eeeeeeeee)[‌8888‌]

Mee eee-eeeeeeeeeeeeee eeeeeeeee ee eeeeeeeeee eeeeeeeeeeeeeeee eeeeee eeeeeeee ee eeeeeee eeeeeeeee ee eee eeeeeeeeeeee eee eeeeeeeeeee ee eee eeeeeeee eeeeeeeeeeeeee (eeee eeeee). Mee eeeeeeeeeeeeeee eeee eeee eeeee ee eeeeeee M ee M eeeeeeeeeeeee ee eeeeeeeeeeee eeeeee 88°M eeee eeeeeee eeeeeeeeee. Meeeeee eee eeeeeee eee-eeeeeeee ee eeeeeeeeee ee eeeeeeee ee ee eeeeeeeeeeeee ee-eeeeeeee eeeeeee ee e eeeeee ee eeeeeee, eeee ee eee eeeeeeeeee ee eee eeeeeeeeeeee eeeeeeeee, eee eeeeee eeeeee ee eee eeeeeeeeeeee, eee eee eeeeeeeeee.[‌8888‌] Mee eeeeeeeeeeeeee eeee ee eeeeee ee eee eeeeeeeeeee ee eeeeeee eeeeeeeeeeeeeee eeee eeeeee 8-eeeeee-8-(eeeeeeeeeeeeeee)eeee-8-eeeeee eee eeeee ee eeeee eeee e eeeeee ee eeeeee eeeeeeeeeeeee, eeeeeeeee eeeeee eeeeeeee eee (eeeeeeeeeeeee)eeeeee, eee eee eeeeeeee eeeeeeee ee α-eeeeee eeeeeeeeeee.[‌8888‌] Me eee eeee eeeeeeeeeee eeee eeeeeee eeeeeee ee eee eeeeeeee eeeeeeeeee eeeee eeeee eeeeee eeeeeeeeeeeee eeee ee eeeeeeeeeeee eeeeeee ee ee eeee ee eeeee ee eeeeeee eeeeeeeeeeeeeeee eeeeeee eeeeeeeeeeeeeeeee eee eee ee MeeeeMeeee eeeeeeeeeee. Meeeeeeee ee eeeeee 8-(eeee-eeeeeeeeeeeeeeeeeee)eeeeeeeee eee eeeeee 8-(eeee-eeeeeeeeeeeeeeeeeee)eeeeeeeeee eeee eeeeeee eeeeeeeeeeeeeee ee eeeeeee eeeeeeeeeeeeee ee 88°M, eeeeeeee ee eeeeeeeee eeee e eeeeee ee eeeeeeeeeeee eeeeeee ee eeeeeeeeeeee eeeeeee 88 eee 8°M, eeee eeeeeeeeeeeeeeee eeeeeee eeeeee 88 eee 88, eeeeeeeeeeeeeeeee (Meeeee 888).[‌8888‌]

Meeeee 888 Meeeeeeee ee (M)- eee (M)-Meeeee 8-(Meeeeeeeeeeeeee)-8-eeeeee-8-(eeee-eeeeeeeeeeeeeeeeeee)eeee-8-eeeeeee[‌8888‌]

Mee eeeeeeeeeeeeee ee eeeee eeeeeeeeee ee 88°M eeeee eeeeeeeeeeeeeeeee eeeee eeeeeeeeeeeeeeeee(M)M,M,M,M-eeeeeeeeeeeeeeeee-8,8-eeeeeee eeeeeeeee eee eeee eeeee ee eeee eeeee ee eeee eeeeee eeee eeeeeeee eeeeeeeee ee eeeeeeeeeeeee. Me ee eeeeeee, (8M,8M)-eeeeeeee(8-eeeeee-8,8-eeeeee-8-ee)eeeeeeee eee eeeeeeeeeeeeee eeeee eeeeeeeeeeee eee eee eeeeeeeeeeeee eeeeeee eee eeee eeeee ee eeeeee(M) eeeeee eee M,M,M,M-eeeeeeeeeeeeeeeee-8,8-eeeeeee eeeeee eeeeee eeeeeeeeeeeeeeeeeeeee eee eeee eeeee eeeeeeeeee eee eeee eee eeeeeeeee eeee eeeeeee, eeeee 8-[(8M,8M)-8-eeeeee-8,8-eeeeee-8-ee]eeeeeeee, ee 88% eeeee.[‌8888‌] Mee eee-eeeeeeee ee eeeeeee eeeeeeeeeeeeeeeeeeee ee eeeeee eeeeeeeeee eee eeee eeee eeeeeeee.[‌8888‌] Meeeeee ee eee eeeeeeeeeeeeee ee eeeee eeeeeeeeee eeeee eeeeeeee eeee eeee e eeeeeeeeeeeeeee eeeeee, eeeeeeee ee eeeeeeeee eeee eeeeeeee, eee eeee eeeeeee.[‌8888‌]

Meeee eee e eeeeee ee eeeeeeeeee eeeeeeeeeeeee ee eee eeee ee eeeeeeeee ee eeeeeeeeeeee eeeeeeee eeee eeeeeee eeeeeeee eeee eee eeeeeeeeee ee eeeeeee eee eeee eee eeee eeeeeeeeee ee eeeeeeee-eeeeeeeeeee eeeeeeeeeeee.[‌888‌,‌8888‌] 8-Meeeeeeeeeeeeee-8-eeeeee eeee eeeee ee eeeee eeee eeeeeee eeeeeeeeeeeee ee 88°M ee eeee eeeeeeeeeeeeee eeeeeeee ee eeeeeeeeee 8-eeeeeeeeeee 8-eeeeeeeeeeeeeee-8-eeeeee eeeee eeeeeeeeee eeeeee, ee eeeee ee Meeeee 888. Me eee eeeeeeeee eeee eee eeeeeeeee eeeeee eee-eeeeeeeeeeeeee eeeeeee ee ee eeeeeeeeeee eeee e eeeeeeeee-eeeeeeeeee eeeeeee eeeeeee eee eeee eee M/M eeeee, eeeee eeeeeeeee ee eee eeeeee eeeeeeeeeee ee eee eeeeeeeeeee eeeeeee eeeeeeeee, eeeeeee eeee eeeeeeeeeee ee eee eeeeee eeeeee eeee eee eeeee-eeeeeeee eeee.[‌8888‌,‌8888‌] M eeeeeeee ee eeeeeee eee(eeeeeeeeeeeeeeeeeee)eeeeeeeeeeeeee eeeeeee eeee eee eeeeeee eeeeee ee e eeeeeeee eeeeeee 8-eeeeeee-8-eeeeeeeeeeeeeee-8-eeeee eee eeeeeee eeeeeeeeeeeeeeeeeeeeee eeeeeee eeee 8-[8-(eeeeeeeeeeeeeeeeeee)eeeeee]-8-eeeeeeeeeeeeeee-8-eeeee ee 88% eeeee.[‌8888‌]

Meeeee 888 Meeeeeee ee 8-Meeeeee-8-eeeeeeeeeeeeeee-8-eeeee eeee Meeeeee Me-eeee-eeeeeeeeeeeeMeeeeee Meeeeee Meeeeeee ee Meeeeeeeee[‌8888‌]

Mee eeeeeeeeeee ee eeeeeeeee eee eeeeeeeeeeeee eeeeeeeee eeeeeeeee eeeeee eee eeeeeeeee ee eeeeeee-eeeeeeeeeee eeeeeee eee eeee eeee eeeeeeeeeeee. Mee eeeeeeeee eeee eeeeee ee eee eeeeeeeee ee ee eeeeee eee ee eeeeeeee ee eeeeeeeee eeeeeeeee, ee ee e eeeee eeeeeeeee ee eeeeeeeeeeee.[‌8888‌] Meee eeee eeee eeee eeee ee eeeeeee eeeeeee eeeeee, eeee ee eeeee eee eeeee eeeeeeeeee ee eeeeeeeeeeeee eeeeeeee eeeeeee.[‌8888‌] Mee eeeeeeeee ee e eeeeee ee eeeeeeee eeee ee eeeeeee eeeeeeeeeeeeeee eee eeeeeee ee-eeee-eeeeeeeeeeeeeeeeeee eeeeeee eeee eeee eeeeeee ee eeeeeeeee eeee eeeeeee eeee eee eeeeeeeeee ee eeeeeee eeee eee eeee eeeeeeeeee ee eeeeeeee-eeeeeeeeeee eeeeeeeeeeee eeee ee eeeeeeeeeeeeeee, eeeeeeeeeeeeeeeeee, eee ee eee eeeeeee eeeeee eeeeee. Mee eeeeeeeeeee ee eee eeeeeee eee ee eeeeeee eeeeeeeeee ee eeeee 8,8-eeeeeeeeeeeeeeeee eeee ee 88°M, eee eeeeeee, ee eee eeeeeeeeeee ee eeeee 8,8-eeeeeeee-8-eeeeeeeeeee-8,8-eeeeeeee, eeeee ee Meeeee 888.[‌8888‌] Mee eeeeee eee eeee eeeeeeee, eeeeeeeee e eeeeeeee eeee 8,8-eeeeeeeeeeeeeeee.[‌8888‌]

Meeeee 888 Meeeeeee ee Meeee (M)-8-Meeeeeeeee-8-ee-8-eeeeee eeee Meeeeee Me-eeee-eeeeeeeeeeeeMeeeeee Meeeeee Meeeeeee ee Meeeeeeeeee eeee 8,8-Meeeeeeeeeeeeeeee Meee[‌8888‌]

Mee eeeeeeee ee eeeeeee ee-eeee-eeeeeeeeeeeeeeeeeee eeeeeee ee eeeeee eeee ee eeeee (M)-8,8-eeeeeeeeeeee-8-ee-8-eeeeee eee eeeee 8,8-eeeeeeeeeeeee-8,8-eeeeeeee eeeeeeee ee eeeeeeeeeee eee eeee eeee ee eeeeeee eeeeeeeeee eeeeeeee eeeeeee.[‌8888‌] Mee eeeeeeeee ee eee 8,8-eeeeeeee eeeeeeee eee eeee eeeeeee ee eee-eeeeeeeeeee 88MMMM eeeeeeeeeeee eeeee eeeee (M)-8,8-eeeeeeeeeeee-8-ee-8-eeeeee 88M eeeeeee ee eee M8 ee M8 eeeeeeeee eee eeeee 88M-eeeeeee eeeeeee eeeeeeeeeeeeeeeeeeeeee eeeeeee.[‌8888‌] Mee eeeeeee eeeeeee eee eeeeeee eeeeeeeeeee eeee eeeeeeee π-eeeeeee eeeeeeeee (eeee eeeee).[‌8888‌,‌8888‌] Mee 88M88M eeeeeeee eeeeeeee eeeeeeeee eeee eeee eeeeeeeeee, ee eeee ee eee MMMMM eee MMMMM eeeeeee ee eee eeeeeee-eeeeee eeeeeeeee, eeee eeeeeeeeeee eeeee ee ee eeeeeeeeeee eeee eeeeee eeeeeeeeeee eeee eee eeeeeeeee eeeeeee eeeeeeee, ee eeeee ee Meeeee 888.

Meeeee 888 MMM Meeee ee e MeeeeeeMeeee π-Meeeeee[‌8888‌]

Meeeeeeeeeeee, eeeeeeeee eeee eeeeeeeeee eeeeeeeeeee eeeeee eeeee eeee eeeeeee eeeeeeeeeeeeee eeeeeeeee ee eee eeeeee eeeeee, eeeeeeee e eeeeeeee eeeeeeee ee eeeeeeeeeee eeeeeee ee e eeeeeeee eeeeeeeee ee eee eeeee ee eee eeeeee eeeee eeeeeeeeeee ee eee eeeeeee. Me eeee eeeeeee eeeee (M,M)-eeee-8,8-eeee-8-eeeeee eeeee, eeeee e eeeeeeee eeee eeeeeee eeeeeeeeeeeeeee eee e 8,8-eeeeeeeeeeeeeeeee eeee eeeeee, eeeee (M)-8,8,8-eeeeeeeeeeeee-8,8,8-eeeeeeeee ee 88% eeeee, eeeeeeeee eee eeeeeeeeeee ee eee eeeeee eeee eee eee eeeeee eeeee eeeeeee ee eeeee eeeeeeeeee ee 88% eee 88%, eeeeeeeeeeee.[‌8888‌] Meeeeeeeee eeeeeeeeeeeeee eeee eeee eeee eeeeeeee ee eeeeeeeeeeeeee ee eeeeeeee eeee ee 8-eeeeee-8-[(M)-eee-8-ee-8-eeee]eeeeeee eeeee eeeee, ee e eeeeeeee eeee eeeeeee ee-eeee-eeeeeeeeeeeeeeeeeee eeeeeee, eeeeeee (M)-8-eeee-eeeee-8-eeeeeeeeee-8,8,8-eeeee-8-ee ee 88% eeeee eeeee eeeeeeeee eee eeeeeeee.[‌8888‌] Me eee eeee ee eeeeeeeee ee eeeeeeee, eee eeeeeee eee eeeeeeee ee eeee 88 eeeee ee Meeeee 888, eeee eeeeeeeeeeeeeeeeee ee eeeeeee ee eee eeeeee eeeeeee eeeee.[‌8888‌,‌8888‌]

Meeeee 888 Meeeeeeeeeeeeeee Meeeeeeee ee ee Meeeeeeeeeeee ee 8,8-Meeeeeeeeeee[‌8888‌]

Mee eeeeee ee eeeeeeeeee eeeeeeeeeeee eeeeeeee eeeeeeee ee eee eeeeee eeeeee ee eeeeeeeeeee, eeeeeeee eeeeeeee ee eeeeeeeeeeeeee eeeeeeee eee eeeeeeeee eeeeeeee eeee eeeeee eeee e eeee ee eee eeeee eeeeeeeeeeeeeeeee ee eee eeeeeeeeeeeeee eeee. Meeeeeeeeeeeeeeeeeee eeeeeee eeeeeeee eee ee eeeeeeeeeeeeeeeeeeeeee ee eeeee eee eeeeee ee eee eeeeee eeeeeeee ee eee eeeeeeeeeeeeee eeeee.[‌8888‌] Meeeeeee eeeeeeee ee eee eeeeeeee ee eeeeee(M) eeeeeeee eeee eee eeee eeeeee ee e eeeeeeee eeeee eeeeeeeeeeeeeee eeeeeee eee 8-(eeeeeeeeeeeeeeeeeeeeeee)eeeeeee ee eeeeeeeeeeeeeee eeeeeee eeee 8-(eeeeeeeeeeeeeeeeeeeeeee)-8-eeeeeeeeeeeeee. Meeeeeeeee eee eeee eeee eeee eeeeeeeee eeee eee eeee eeeeeeeeeeeeee eeeeeee ee eee ee eee eeeeeeeee eeeee eeeeeee eee ee eeeeeeeeee eeee eeeeeeeeeeee, eeee eeeeeeeeeeeee ee eee eeee eeeeee eeeeeeeeeeee eeeeee.[‌8888‌] Meeeeee eeeeeeeeeeee eee ee eeeeeeee eeeeeee ee eeeee eeeeeeeeee eeeeeeee[‌8888‌‌8888‌] eee eeeeeee ee eeeee eeeee ee eeeeeeeee eeeeeeeeeeeee.[‌8888‌] Meeeeeee ee eeeeeeeee eeeeee ee eee- eee eeeeeeeeeeeeeeee eeeeeeeeeeeeeeeeeee eeee eeee eeeeeeee ee eeeeeeeee ee eee-8-eeeeeeeeeeeeeeee eeee eeeeeeeeeeee(M) eeeeeeee eeeeeeee ee eeeeeeeee eeee eeeeeeeeeeeee. Mee eeeeeee, eeeeeeee ee eee eeeeeeeeeeeeee eeeeeee, eeeeeeee eeee e eeeeeeee ee eeeeeee eee-8-eeeeeeeeeeeeeee eeee eeeeeeeeeeeeeeeeeeeeeee eeeeeee, ee eeeeeee eeeeeeee eeeeeeee eeeeeeee eeeee eee M-eeeeeeeeeeeeeeeeee eeeeeeeeeee (Meeeee 888). Me eee eeeeeeee ee eeeee, eeeeeeeee eeee ee eeeeeeeeeeee, eeeeeeeeeee ee Meeeee 888, eeee eee eeeeeeeeeee eeeeeeeeeeeeeeee eeeeeee ee eeeeeeeee eeeeee.[‌8888‌]

Meeeee 888 Meeeeeeee ee Meeeeee Mee-8-eeeeeeeeeeeeeee eeee Meeeeeeeeeeee(M)Meeeeeeee Meeeeee Meeeeeee ee Meeeeeee eeee ee Meeeeeeeeeee[‌8888‌]

Meeeeeeee ee eeeeeeeeeee eeeeeeee eeee eeeeeeee eeeeeeeeeeeeeeeee eeee eeee eeee eeeee ee eeeeeee eeee eeee eee-eeeeeeeeeeeeeeeee ee eee eeeeeeeeeeee ee eeee eeeeeeeee eeeeee ee eeeeeeeeeeeeeeeee. Mee eeeeeee, e eeeeeeee ee eeeeeeeeeeeeeeeeeeeee eeeeeee eeee eeeeeeeeeeeeeeeeeeeeeeee eeeeeee eee ee eeeeeeeeeeeeeee ee 88 ee 88°M eeeee eeeeeeee[(M)-eeee-8-eeee]eeeeeeeee ee eeeeeeeeeeee eeeee eeeee eeeeeeeeee eeee ee eeeeeee eeeeeee ee eeeeeeee eeeeeeee eee eeeeee eeeeeee. Meeeeeeee, e eeeeeeee ee eeee-eeeeeeeeeeeeeeeeeeee eeeeeeee eeee eeeeeeeeeeee-8-eeeeeeeeeeeee eeeeeee eee ee 88 ee 88°M eeeee eeeeeeee[(M)-8,8,8-eeeeeeeeeeee-8-eeee]eeeeeeeee, eeee ee e eeeeeeeeeeee eeeee.[‌8888‌] Me eee eeee ee eeeeeeeee ee eeeeeeee eeeeeeeeeeeee eee eeeeeeee, eee-eeeeeeee eeeeee eee eeeeee ee eee eeeeeeee eeeeee. Meeeeeeee eeee eeeeeeee eeeeeeee eeeeeeeeee eeeeee eee-eeeeeee eeee eee eeeeeeee-eeeeeeee eeeeeeeee ee eee eeeeeeee eeeeeeeeeee eeeeeeeeee eee eeeeee ee eeeee eeeeee eeee eee ee eeeeeee. Meee ee eeeeeeeeeee ee Meeeee 888.[‌8888‌] Mee eee-eeeeeeee ee eeeeeeeeeee ee eeeeeeeeeeee eeeeeeee ee eeeeeeee eeee 8-eeeeeeee-8-eee eeeee (M)-8-eeeeeeeee-8-ee-8-eee ee 88% eeeee.[‌8888‌] Meeeeee, eee β-eeeeeeeeeeeeeeeee eeeeeeeeeee eee eeeeeeee eeeee ee. 88°M eee, ee eeeeeeee, eeeeeeeeeeeeeeeee ee eeeeeeeee eeee, ee eeeeeeeee ee Meeeee 888. Me eee eeeee eeee, eeeeeeeeee ee eee eeee eeeeee eeee eeeeeee e eeeee ee eeeeeee, eeeeeeeee α,β-eeeeeeeeeee eeeeeee ee eeeee ee Meeeee 888, eee ee eee eeeeeeee eeeeeeeeeeeeeeeee eeee eee eeeeee eee eeeee ee eee eeeeeeeee eeeeeeeee.[‌8888‌]

Meeeee 888 Meeeeeee ee MeeeeeeeeeeMeeeeeeee Meeeeee ee M-Meeeeee-M,M-eeeeeeeeeeeee[‌8888‌]

Meeeee 888 Meeeeeee ee Meeeee(M) Meeeeeee ee 8-Meeeeeeee-8-eee Meeeeeeeeee[‌8888‌,‌8888‌]

Meeeeeeee ee eeeeeee eeeeeee- eee eeeeeeeeeeeeeeeee eeee eeeeeee eeeeeeeeeeeeee eeeeee eeee eeee eeeee ee eeeeeee eeeeeeeeeee eeee eeee eeeeeeeeeeeeeeeee ee eeee eeeeeeee eeee eee eee eeeeeeeee eeeeeeeeeee ee eeeeeeeeee eeeee. Meeeeee eeeeeeee,- eeeeeee-, eee eeeeeeeeeeeeeeee eee eeee (M)-8-eeeeeeeeeee eeeeeeee ee eeeeeeeee eeeeee, eee eee eeeeee eeee eeeeeeeeeeeeeee eee ee eee eeeee ee 8888%. Mee eeeeeee, eee eeeeeeee ee eee eee-eeeeeee eeeeee ee eee eeeeeeee ee eeeeeee eeeeeeeeeeeeee ee eeeeeeeee eeee eeeeeee eeeeeeeeeeeeee eeeeee eeeee (8M,8M)-eeee-8,8-eeeeee eeeeeeeeeeeeee eeeeee ee 88% eeeee, eee e eeeeeeeeee eeeeeeee eeee eeeeeeeeeeeeeeeeee eeeeeeee ee eeeeeeeeeeeeeee eeeeeeee ee eeeeeeeee eeee e eeeeeeeee eeeeeee eeeeeeee ee eeeeee eeeeeeeeeeeeeeeee eeeee (8M,8M)-eeee-8,8-eeeeee ee 88% eeeee.[‌8888‌]

Meee eeee eeeeeeeeeeeeeeeee eee eeee eeee eeeeeeee ee eeee eeeeeeeee ee eeeeeeeeeeeeee-eeeeeeeeeeee eeeeeeeee eeee α,β-eeeeeee eeeeeeee eeeeeeeee, eeeeeeeee eeeeee, eeeeeeeeee eeeee, eeeeeeeee, eee eeeeeee. 8-Meeeeeeeeeeeeee eeee eeeee (M)-8-eeeeeeeeee-8-eeeee eeee ee 88% eeeee ee e eeeeeeee eeeee eee eeeeeeeeeeeeeeee-8-eeeeeeeeeeeeeeeee eeeeeee ee 88°M eeeee eeeeeeeee eee eeeeeeee eeeeeee eeee eeeeeeee, eee eee eeeeeeeeeeeeeeeeeeeeeeeee eeeeeee eeeee (M)-eeee-8-eeee eeeeee eeeeee ee 88% eeeee ee e eeeeeeee eeee eeeeeee eeeeee eeeeee.[‌888‌] Me eeeeee ee eeeee eeee eeeeeeeee ee eeeeeeeeeee ee eeee-8-eeee eee eeeeeeeee eeee eee ee eeeeeee eee ee eeeee ee eeeeee ee e Meeeeeee eeeeeee ee eee eeeeeeee ee eeeeeee eeeeeeeeeeeeeeeeee.[‌8888‌,‌8888‌] Meeeeeeee eee eeee eeeee ee eeee eeeeeeeeee ee eee eeeeee eeeeeeeeeeeeeee eeeeeeee ee (8-eeeeeeeeee-8-ee-8-ee)eeeeeeeee eeeeeee ee 8-eeeeeeeeee-8-eeeee eeee, eeeee eeeee eee M-eeeeeeeeeeee ee 88% eeeee. Me eee eeeeeee eee eeeee eeeeeeeeeeee eee eeeeeeeeeeee eeee ee eee eeeeeeeeee.[‌8888‌] Meeeeeeee ee eeee-8-eeee eeee ee eeeeee ee e Meeeeeee eeeeeee eee eeeeee(M) eeeeee ee eeeeeee eeeee eeee eeeeeeee eeeee eeee eeeeeee eeeeeeee ee eeeeeeeeee. Mee eeeeeee, eee eeeeeeee eeeee eeeeeeeeeeeeee eeeeeee eeeeeeee ee eeeeeeeee eee eeeeeeee eeeeeee eeee eeeeeeeee eeeee eeeee 8-[8M8]eeeeeeeeeeeee-8-ee-8-ee ee 88% eeeee.[‌8888‌] Meee eeee ee eeeeeeee eee eeee eeeeeeee ee eeeeeeeee eeee eeeeeee eeeeeeeeeeeee eeeeeeee eee eeeeeee eeeeeeeeeeeeee eeeeeeee ee eeeeeeeee eeee e eeeeee ee eeeeeeeeeeeee, eeeeeeeee eeeee eeeeeee eee eeeee eeeeeeeeee.[‌8888‌]

Meeeeeeee eeee eeeeeee eeeeeeeeee, eeeeeeeeee, eee eeeeeeee eeee eeee eeeeeee ee eeeeee eee eeeee eeee eeee eeeeeeeeeeeeeeee eeee eeeeeee ee eee-eeeeeeee eeee eee eeeeee eeeeeeee ee eee eeeeee eeee eeee ee eeeeeeeeeee ee eee eeeeee eeeeeeeeeeeee. Meeeeee eee-8-ee-8-ee eee eeeee ee eeeee ee eeee-eeeeeeee (Meeeee 888), eeee-8-eeee eeeeeeee eeeeee eeee ee eeeeeeeeeeeeee eeeeeee eee eeeeeeeee eeee eeeeeeee eeee ee eeeeeee eeeeeeeeeeeeee eeee eee eeeeee eee-eeeeeee.[‌8888‌] Meeeeeee eeeeeeeee ee eeeeeeeeee eeee eeee eeeeee eeeeeee eee eee eeeeeeeeeee ee Meeeee 888.[‌8888‌,‌8888‌,‌8888‌,‌8888‌‌8888‌] Meeeeeeee ee (eeeeeeeeeeeeeeeeeeeeeee)eeeeeee eeee eeee eeee eeeeeee.[‌8888‌] Meeeeeeee ee eeeeeee eeeee(eeeee)eeeeeeee eee eeeeeee eeeee(eeeeee)eeeeeee eeee 8-eeeeeeeeeeee-8-(eeeeeee-8-eeeeeeee)eeeeee eeee eeee eeeeeeee eeee eee eeeeee ee eee-eeeeeeee ee eeee eeeeee eeeeeeeeeeeeeeee, eeee eeee eee eeeeee eeeeeeee ee eee eeeeeeee eeeeee.[‌8888‌] Meeeeeee eeee eeee eeee eeeee ee eee ee α,β-eeeeeeeeeee eeeeeeee. Mee eeeeeee, eee eeeeeeee ee eeeeeee eeeeeeeeeeeeee ee eeeeeeeee eee eeee ee 8-eeeeeeeeee-8-eeee eeeeee eeeeeee eeeee eee eeeee ee 88% eeeee.[‌8888‌]

Meeeee 888 Meeeeeee ee Meeeeeeeeeee(M) Meeeeeee ee α,β-Meeeeeeeee Meeeeeeeee[‌8888‌]

Me eeeeeeeee eeeeeeeeeee ee eee eee ee eeeeee-eeeeeeeeeee eeeeeee ee eeeee ee eee eee ee e 8,8-eeeee-eee eeeeeeeeeeeee eeeeeeee.[‌8888‌‌8888‌] M eee-eee eeeeeeee eee eeee eeeeeee eeee eeee (eeeeeeeeeeeeeee)eeeeeee ee e eeeeee ee eeeeeeeeeeeeee eeeeeee eeee eeeeeee eeeeeeeeeeeeeee.[‌8888‌] Mee eeeeeee, eee eeeeeeeeeeeeee ee (eeeeeeeeeeeeeee)eeeeeee eeee eeeeeee eeeee(eee-8-eeee)eeeeeee eeeeeeee ee e eeeeeeee eeee eee-eeeeeeeeeeee eee eeee eeeee eeeeeee eeeee (8M)-8-eee-eeeee-8-eeeeeeeeee-8,8-eeeee ee 88% eeeeeee eeeee, ee eeeee ee Meeeee 888. Mee eeeeeeeee ee eeeeeeeeeeeee eeeeeeeeeee eeeeeeee eeee eeeeeeeee ee eeeeeee eeeeeeeeee eeee Meeeeeee eeeeeee-eeeeeee eeeeeeeeeeeeeee eeeeeee eeeeeeeee eeee eeee eeeee ee eeeee eeee eee(eeeeeeeeee)eeee ee eeee eee eeeeeeeeeeee eeeeeee eeeeeeee ee eeeeeeeeeee β-eeeeeeeeeee ee eeeeeee 8,8-eeeeeeeeeeeee eeeee-8,8-eeeeee ee eeee ee eeeeeeeee eeeeee. Mee eeeeee, eeeeeeeeeee ee Meeeee 888, eee eeeeeeeee eeeeeee ee eeeeee eee eeeeeeeee ee 8,8,8-eeeeeeeeeeeeee eeeeeeeeeee ee eeeeeeeeee e eeee eeeeeeeee ee eeee ee eee eeeeeeee ee eeeeeeeeeee eeee 8,8-eeeeee-8-eeeeeeeeeeee.[‌8888‌]

Meeeee 888 Meeeeeeee ee (8M)-8-eee-Meeee-8-eeeeeeeeee-8,8-eeeee[‌8888‌]

Meeeee 888 Meeeeeeee ee Meeeeeeeeee ee Meeee-8,8-eeeee eeee Meeeeee Meeeeeeeee[‌8888‌]

Mee eeeeeeeee eeeeeeeeee eeee eeee eeee eeeeeeeeeee ee eee eeeeeee eeeeeeeeee eeeeeeeee eee eeeee ee eeeeeeeeeeeeee eeeeeeeee ee eeeeeeeee. Meeeeee eee eeeeeeeeee ee eeeeeeeeeeee eeee eeeeeee ee eeeeeee eeeeeee eeeeeeeee, eee eeeeee ee eeeeeee eeeeeeeee eee eeeee eeeeeeeee ee eeeee ee eeeeeeeeee eeee eee eeeeee ee eeeeeee eeeeeeeee eee eee eeeeeeeee ee eee-eeeeeeee eeeee. Mee eeeeeeeeeee ee eeeeeeeee eeeeee eeeeeeeeeeeeee eeeeeeeee-8-eeeeee ee e eeeeeeee eeee eeeeeeee eeeeeeeee eeeeeeee ee e eeeeeee ee ee α,β-eeeeeeeeee eeeee eeeeeeee ee eeeeeeeeeeeeee eeeeeee ee eee eeeee ee eeeeeeeeeee ee Meeeee 888. Mee eeeeeeeeee ee eee eeeeee ee eeeeeeee ee eeee eeeee ee eeeeeeeeeee eee eee-eeeeeee eeeeeeee eeeeeee ee 88°M eee eeee eeeeeeee eee eee eeeeeeeeeee eeee eeeee eeeeeee eeeeeeeeeeeeeeee.[‌8888‌] Mee eeeeee eee eeee eeee eeee ee e eee eeee ee e eeeeeeeee ee (±)-eeeeeeeeee eeee eeeee eeeeeeee eee eeeeeeeeeeeeee ee eeeeeee 8,8-eeeeeeeeeee-8-eeeeeeeee eeee eee eeeeeeeeeeee eeeeeee eeeeeeeee eeee 8-eeeeeeeeee-8-ee-8-eeeeeeeeeee eeeeeeee eee eeeeee(M) eeeeee eee M,M,M,M-eeeeeeeeeeeeeeeee-8,8-eeeeeee ee eeeeeeeeeeeeeee eee eeeee eeeee eee eeeeeeee eeeeeee ee 88% eeeee.[‌8888‌,‌8888‌] Mee eeeeee eee eeee eeeeeeee ee eeeee eeeeeeeee eeeeeeee eeeeeeeee ee eee eeee eeeeeeeeeee eeeeeee eeee 8-eeeeee-8-(eeeeeeeeeeeeeee)eeeeeeeeeeee, eeeeeeeee ee 8888eee% ee eeeeee(M) eeeeeeeeeeeeeee eeeeeee eeeeeee, eeeeeeeeeee ee Meeeee 888.[‌8888‌] Meee eeeeeeeeeeee eeeeeee ee eee eeeeeeeee eeeeeeeeeeeee eeeeeee ee eeeeeeeee ee eeeeeeeee ee eeeeeeeeee eeeeee.[‌8888‌]

Meeeee 888 Meeeeeeee ee e Meeeee Meeeeeeeeeeeee Meeeeeeee-8-eeeee[‌8888‌]

Meeeee 888 Meeeeeeee ee e Meeeee Meeeeeeeeeeeee Meeeeeeee-8-eeeee Meeee Meeeeeeee Meeeeeee Meeeeeeee ee e Meee Meeeeeeeeee[‌8888‌]

Mee eeeeeeeee ee eeeeeeeeeeeeeee eee eeee eeee eeeeeee eee ee e eeeee-eeee eeeeeeee eeee eeeeee eeee eee eeeeeeeeeeeeee ee eeeee eeeeeeeeee eeeee eeeee eeeeeeeeeeeee eeee ee eeeeeee eeeeeeeeeeeeeeeeee eee eeeeeeeee ee eeee eeeeeee eeee eeee eeeeeeeee.[‌8888‌] Me eeeeeee ee eeeee ee Meeeee 888, eeee eee eeeeeeeeeeeeee eeeeeeeee ee ee ee eee eee eeeeee eeeeeee ee eeeeee. Me eeee eee eeeeeeee eeeeeee eeee eeeee eeeeeeeeee, eeee eeeeeee eeee eeeeeeeeeeeeeeeeeeeee, eeee e eeeeeee eeee eeeee MM eeeeeeeeee ee 8888ee8.

Meeeee 888 Meeeeeeee ee ee Meeeeeeeeeee ee e Meeeeeeeeeeeee Meeeeeeee eeee Meeee Meeeeeeeee[‌8888‌]

Mee eeeeeeeee ee eeeeeeeee eeeeeee eeeeeeee eee eeee e eeeee eeeeeeeee ee e eeeeee ee eeeeeeee eeeeee eeee eeee eeee eeeeeeee ee eeeeeee ee eeeeeeeeeeeeee eeeeeeeee ee eeeeeee. Mee eeeeeee, eeeeeeee, ee eeeeeeeeeee eeeeeeeee ee eee eeeeeeee eeeeee (Meeeeeeeeeee eeeeeeee), ee eeeeeeee ee eeeeeeeee ee eee eeeeeee eeeeeeee ee eee eeeeeeee ee 8-eeeeeeeeee-8-eeeeeeeeeee ee eeeeee eeeee eeeeee.[‌8888‌] Mee ee eee eeeee eeeeeeee, ee eeee eeee eee eeeeeeee eee eeeeeeeeee ee eee eeeee eeee eeeeee (Meeeeeeeeeeeeee eeeeeeee), eeeeeeee ee eeeeeee eeeeeee eeee ee eeeeeeeee ee eeeee ee Meeeee 888.[‌8888‌] Mee eeeeeeee ee (M)-()-8-eeeeeeeeee-8-eee eeee eeeeeee eeeeeeeeeeeeeee eee eeee eeeee ee eeeeee ee eee eeeeeeeee ee ee (M)-eeeeee,[‌8888‌] eee eeee eeeeeeee, eeeee e eeeeee eeeeeeeee, eee eeee ee eee eeeeeeeee ee (M)-()-eeeeee eeeeeeeee-8,8-eeeeeeee, eeeee eee eeee eeeeeeeee eeee (M)-()-eeeeee (8M)-eeeeeeeee-8,8,8-eeeeeeeee, eeeee eee 88% ee eee eeeeeeee ee eee eeeeeee eeeeeee.[‌8888‌] Mee eeee eeeeeeeeeeeeeeeee ee eee eeeeeeeee ee eeeeeeeeeee eeeeeee eee eee eeee eeee eee eeeeeeeeeeeeeee eeeee eeee e eeee eeeee ee eeeeeeeeeeeee eeee eeeeeeeee ee eeeeeeeeeeeee eee eeee eeeeeeee ee eeee eeeeeeeee. Mee eeeeeee, eee eeeeeeee ee eee eeeeeee eeeeee eeee eeeeeeeeeeeeeee eeeeeee eee eee eeeeee(M) eeeeeeeeeeeeee eeeeeee eeeeeee ee (M)-8-eeeeeeeee-8-ee-8-eee eeeeeeee ee eeeeeeee eeee eeeeee eeeee (M,M)-8-eeee-8,8-eeeeeeeeeeee-8,8-eeeee ee 88% eeeee, eeee ee e eeeeeeeee ee eeeeeee, eee eeeee eeeeeeeee ee eee Meeeeee'e eee.[‌8888‌] Mee eeeeeeee ee eeeeeee eeeeeeeeeeeeeee eeee eeeeeeeee eee eeee eeee eeeeeeeeeeeee eeeeeee eeee eeeee eeeeeeeeee eeeee eee eeee eeeee, eeeee (8M,8M)-eeee-8,8-eeeeeeee, ee 88% eeeee eeee e eeeeee ee 88%.[‌8888‌]

Meeeee 888 Meeeeeeee ee eee Meeeeeee Meeee Meee Meeeee Mee Meeeeeeeee[‌8888‌]

Mee eeeeeeeee ee eeeeeeeeee eeee eeeeeee eeeeeeeeeee eeeeeee eeeeeeee eeee eeeeeeeeeeeeeeeee eeeee eeee eeee eeeee eeeeeee ee eee eeeee eeeeee eeeee eeeeeee eee eeeeeeeeee eeeeeeee ee eee eeeee eeeeee. Mee eeeee ee eee eeeeee eee eeeeeeeeeee ee ee eeeee eeeee ee eee eeeeeeeeeee ee eee eee ee eeeeeeeeeeeeee ee eeeeeee. Mee eeeeeee, ee eee eeeeeeeee ee eeeeeeeee, eee Meeeeeeeee eeeeeeee eeeeeeee eeeeeee'e eeeee eeeeee eeeee eeee eeeeeeeee ee eee eeeeeeeeee eeeeeeee ee ee eeeeeeeeeee eeeeeee ee eee eeeeeeeeeee eeeeee.[‌8888‌] Me eee eeeeeeeeeee eeee eeeeeeeee eeeeee eeeeeeee eeeeeeee eeee eeeeeeeeeeee eeeeeeee eeee eee eeee eeeeeee, eeee eeee eeeeeee ee eee eeeeeeee ee eee eeeee eee eeee eee eeeeeee ee eeeeeeeeeeeeeee. Mee eeeeeeee eeee ee eeeee eeeee ee eeeee ee eee eeeeeee eeeeee eeeee eee eee eeeee eeeeee ee M88 eeeee eeee eeeeeeeeee eeeeeeee.[‌8888‌] Meeee-eeeee eeeeeeeee ee e eeeeee ee eeeeee eee eeeeeeeeeee eeee eeee eeeeeee eee ee eeeeeeeeee eee (M)-eeeeeeeeeeeeeeeee eeee eee eeeeeeee ee eee eeeeeeee ee eeeeeee eeeeeeeeeeeeeee eeee ee eeeeeee eeeeeeeeeeeeee ee eeeeeeeee. Mee eeeeee ee eee eeeeeeeeee eeeeeeee eee eeeeeeee ee >88.88% ee eee eeeeeeeeeeeeee eee ee eeeeeeeeeee ee Meeeee 888 ee eee eeeee eeee ee e eeeeeeeee ee eee-eeeeeeeeee, eee eeeeeeeee eee eeeeeeeeee ee eee eeeeeee eeee eeeeee, Meeeeeeeeeee eeeeeeeeee.[‌8888‌] Meeeeeeeeeeeeee eeeeeeeee ee eee eeeeeeee eeeeeee eeee (Meeeeeeeeee eeeeeeeee) eee eeeeeeeee eeee eeee eeee eeeeeeee.[‌8888‌,‌8888‌]

Meeeee 888 Meeeeeeee ee eee-Meeeeeeeee[‌8888‌]

Mee eeeeeeeeeeeeeee ee eeeeeee eeeeeeee eeee ee eeeeeee eee eeee ee ee eeeeeeeeee eeeeeeeeee eee eeee eeeeeeeeeee eee eeee eeee eeeeeeeeeeee ee eee eeeeeeeee ee eeeeeeeee[‌8888‌] eee ee e eeeeeeeee ee eeeeeeee eeeeeeee eeeeee eeee eeeee eee eeeeeee ee 88% eeeee.[‌8888‌] M eee eeee ee eee eeeeeeeee ee 88-eee-8-eeeeeeeeeeee eeeeeeeeeee eee 88-eee-88-eeeeeeeeeeee eeeeeeeeeee eeeeeeee eee eee-eeeeeeeeeeeeeee eeeeeeeeeeeeee ee ee eeeeeeeeee eeeee eee ee eeeeeeeeeee ee Meeeee 888. Meeeeeeeeeeeee eeeeeeeee ee eeeeeeeeee eeeeee eeee eeee eeee eeee ee eee eeeeeeeee ee eeeeeeeeeeeee eeeeeeeee[‌8888‌] eee ee e eeeeeeeee ee (±)-eeeeeeeeeeee M.[‌8888‌]

Meeeee 888 M Mee Meee ee eee Meeeeeeee ee 88-Mee-8-eeeeeeeeeeee[‌8888‌]

Mee eeeeeeeeee eee eeeeeeeeee ee eeeeeeeee-eeeeeeeee eeeeeeee ee eeeeeeeeeeeeeee eeee eeee eeeeeeeee ee eeeeeeeeeee ee eee eeeeeeeee ee e eeeeeee eeeeeeeee eeee Meeeeee eeeeeeeeee, eeeee ee Meeeee 888.[‌8888‌] Meeeeeeee, eee eeeeeeeee ee eeeeee eeeeeeeee, eeeeeeeee, eee (M)-eeeeeee eeee eeee eeeeeeee eeeeeeee eeee eee eeeeeeeeeeeeee ee eeeeeeeee eeee eeeeeeeeeeeeeeeeeeeeeee eeeeeee, eeeee eeeee ee-(M)-eeeeeeeeeeeeee eee eeee (M)-eeee-8-eeeee eeee ee 88% eeeee eeeee eee eeee-eeeeeee eeeeeeee eeee β-eeeeeeeeeeeee.[‌8888‌]

Meeeee 888 Meeeeeeee ee e Meeeeee Meeeeeeee eeee Meeeeee eeeeeeeeee[‌8888‌]

Meeeeeeeeeee Meeeeeeee

8-[(Meeeeeeeeeeeee)eeeeee]eee-8-eee (88); Meeeeee Meeeeeeee:[‌8888‌]

M 8.88M eeee ee Me8M ee [(eeeeeeeeeeeeee)eeeeee]eeeeeeeee eeeeeeee (88eM, 88eeee) eee eeeee ee 8°M ee e eeeeeeeeee ee MeMe (8.8e, 88eeee) eee 8M MeM (88eM, 88eeee) ee Me8M (88eM). Mee eeeeeee eeee eeeee e eeeeee eeeeeeeeeee eee eeee e eeeeeeeeeee eeee eeeee eeee eeeee eee eeeeeee ee 8°M eee 8e. Mee-8-eee (8.8e, 88.8eeee) eee eeee eeeee eee eee eeeeeee eee eeeeeee ee eeee ee 88°M eee eeeeeee ee eeee eeeeeeeeeee eee 88e ee eeee e eeeee eeee eeeee eee eeeeeeeeee eeee eeeeeeee ee MM8 eeee (888eM). Mee eeeeeee eee eeeeeeee eee eee eeeeeee eeeee eee eeeeee eeee eeeee (88eM) eee eeeee (MeMM8). Mee eeeeeee eee eeeeeeeeee eee eee eeeeeee eeeeeeeee eeeeeee e 88-ee Meeeeee eeeeee ee eeee 88; eeeee: 8.8e (88%); ee 88°M/88Meee.

(M)-8-Meeeeeeeeee-8,8-eeeee (88); Meeeeee Meeeeeeee:[‌8888‌]

Meeeeeeee eeee (Meee; Meeeeeee, Meeeeee Meeeeeeee, Meeeeeeeee Meeeee MMM), Meeeeeeee (8888), e888, eeee eeeeeeeeee eeee Meee Meeee&Meee, Mee.

MMMMMMM: Meee eeeeeeeeee eeeeee ee eeeeeeeee ee ee eeeeeeeee eeee eeee eeeeeee ee eee eeeeeeeeee eeee ee eeeeeeee eeeeeee.

M eee, eeeeee-eeeeee, eeeee-eeeeeeee eeeee (8M) eee eeeeeeee eeee e Meeeee-eeeeee eeeeeeee eeeeeee eee eee e eeeee-eee eeeeeeee eeee e eeeeee eeeeee. Mee eeeee eee eeeeeee eeee MeMeMMM eeeeeee (88.8e, 8.888eee) eee ee eeeee ee eeeeeeee M8 eeeeeeeeee eee eeeeeeeeeee ee eee eeeee ee eeeeeeee eeeeee ee eeeeeeeeee eeee ee eee eeee eee eeeeeeeee eeee eee eeeee eee. Me8M (888eM) (eeeeeeeee eeee eeeeee eeeeeeeeeeee eeeee eeeeeee eeeee) eee MMM (888eM) eeee eeeee eeeee e eeeeeee ee eeeeeee. Mee eeeeeee eee eeee eeeeeee eee e eee eeeeeee ee 88°M eeeeee eeeeeee eee eeeee eeeeeeeee eeee ee 88°M. M 8.88M eeee ee MeMeMe (88eM, 8.888eee) eee eeee eeeee eeeeeeee ee eeeeeee ee eeeeeee eeee e eeeeee ee 88eee. Mee eeeeeeeee eeeeee-eeeeee eeeee eee eeeeeee ee 88°M eee 8e eeeeee eee-8-eee (88.8eM, 8.888eee) eee eeeee eeee e eeeeeee ee eeeeeee eeee e eeeeee ee 8eee. Mee eeeeeee eee eeee eeeeeee ee 88°M eee e eeeeeee 8e, eeeeee ee 88°M, eee eeeeeeeeee ee eeee eeeeeeeeeee eeeeee eee eeeeeeeeee eeeeeeee ee MMMM (88.8eM, 8.888eee) [e eeeee eeeeeeeeeee ee eee eee ee MMMM[‌8888‌]] (eeee eeeeeee eeee eeeeeeee eeeeee eeeeeeeee) eee eeeee eeeeeee (88.8eM, 8.888eee). Mee eeeeeee eee eeeeeeeeeee eeeeee ee 88°M eee eeeeeee ee eeee eeeeeeeeeee eee 88e, eeee eeeeee ee 8°M, eee eeeeeeee ee eee eeeeeeee ee e eee. ee MM8Me eeee eee eee eM eeeeeeee ee 8 ee eee eeeeeeee ee ee MM8 eeee (88eM). Mee eeeeeee eee eeee eeeeeee ee eee eee eeeeeee ee 88°M eee 8.8e eee eeeee ee e eeeeeeeeee eeeeee eeeeeeeeee M8M (88eM) eee Me8M (88eM). Mee eeee eeee eeeeeee eeeee eee eeeeeeeee eee eee eeeeeee eeeee eee eeeeee eeee eeeeeeeeee eeeeeeee ee eee ee MM8Me eeee (eM8) eeeee eee eeeeeeee eeee eeeeeeeee. Mee eeeeeee eeeee eee eeee eeeeee eeee M8M (88eM), eee. ee MeMe eeee (88eM), eeeee (MeMM8), eeeeeeee, eee eeeeeeeeeeee ee eeeeee eeeeeeeeeee ee 88°M eeee 88eee. Mee eeeeeeee eeeeee eee (88.8e) eee eeeeeeee ee eeeeeeeeeeee eeeeeee e 88-ee Meeeeee eeeeee ee eeee 88 ee e eeeeeeeee eeeeee; eeeee: 88.8e (88%); ee 88°M/8.88Meee.

(M)-8-Meeeeee-8-eee (88); Meeeeee Meeeeeeee:[‌8888‌]

Meeeeeeee eeee (Meeeeeee; Meeeee; Meeeeee, Meeeeee Meeeeeeee, Meeeeeeeee Meeeee MMM), Meeeeeeee (8888), e888, eeee eeeeeeeeee eeee Meee Meeee&Meee, Mee.

Meeeeee Meeeeeeeeeeeee:[‌8888‌]

M eee, eeeee-eeeeeeee, eee-eeeeee eeeee (888eM) eee eeeeeeee eeee e eeeeeeee eeeeeee eee, e eeeeee eeeeee, eee e eeeee-eee eeeeeeee, ee eee ee eeeee eee eeeeeeee e eeeeee eeeeeee eeeeeeeeee M8. M Me-888 eeeeeeeeeee eee eeeeeeee eeee eee eeeee eeeeeee eee eeeeee eee eee eee ee eee eeeee eee eeeeeeee ee M8 ee eeeeeeee eeeeee ee eeeeeeeeee eeee ee eee eeee eee eeeeeeeee eeee eee eeeee eee. Mee eeeee eee eeee eeeeeee eeee MeMeMMM eeeeeee (88.8e, 8.8888eee) eee Me8M (888eM), eeeeeeee ee e eeee ee 88°M eee eeee e ee. 8.8M eeee ee eeeeee ee MeMe (8.88eee) eee eeeee eeeeeeee eeee eeeeeeee ee eeeee ee e eeeeeee eeeeeee eee eeeeee ee e eeee eeee eeee eee eeeeeeeeeee eee eee eeeeee 88°M. Mee eeeeeeee eee eeee eeeeeeeee ee 88°M eee e eeeeeee 88eee ee eeeee ee eeeeeee e eeee-eeee ee eeee eeee eeee ee eee eeeeeee.

Meeeeee Me[(M)-eee-8-eeee]eeeeeee:[‌8888‌]

M eeeeee ee eeeeeeeee eee eeeeeeee eeee e eeeeeeee ee eeeeeee ee eeeeeee eee eee eeeeee eee eeeee eeeeeeeeee ee 88°M eeeeee e eeeeeeeee eee eeee eeeeeee e eeeeee eeee (88ee×8ee) eeeeee eeee eeeee MeMe8. Mee eeeee ee eeee eeee ee eee eeeeeeeee eee eeeeeee eeeeeee eeee eeeeeeeee ee eeeee ee eeeeee eee eeeeee eeeeeeeee eee eeeeeeee eeeeee (8.88M) ee eeeeeeeee. M eeeeee eeeeeeeee ee eee eeeeee ee eeeeeeeee eee eeeeeeeeee eeee eee eeeee eeeeeee eee eeeeee eeee eee eee ee eeeee 8ee eeeee eee eeeeeee ee eee eeeeeee ee eee eeeeeee eeee eee eee eeeeeeee eee eeeee eeeeee eeeeee eee eeeeeee. Mee eeee eee eeee eeeeee ee 88°M eee eee eeeeeeeee (8.88M, 8.88eee) eee eeeeeee eeee eee eeeeeee eeeeeee eeee eeee e M8M eeeeeeeee, eeeeee eeee eeee eee eeeeeeeeeee ee eee eeeee eee eee eeee eeeee 88°M. Mee eee eeeee eee eeee eeeeeee eee eee eeeeeee eee eeeeeee ee 88°M eee 88eee.

(M)-8-Meeeeee-8-eee (88):[‌8888‌]

M eee, eeeee-eeeeeeee, eee-eeeeee eeeee (888eM) eee eeeeeeee eeee e eeeeeeee eeeeeee eee, e eeeeee eeeeee, eee e eeeee-eee eeeeeeee eee eee eeeeeee eeee M8 (88.8e, 8.888eee) eee eeeeeee eeee eeeee ee eeeeeeee eeeeeeeeee eee eeeeeeeee eeeee ee eee eeee. Meeee MMM (88eM) eee eeeee eeeeeee eee eeeeee eeee e eeeeeee eee eeeeeeee eee eeeeeeeee ee eeeeeeee eee M8. Mee eeeee eeeeeeeeee eee M8 eeee eee eeeeeeeee ee eee eeeee eeeeeeeeee eee eeeeeee eeeeeeeeeeee eeee, eeeee eee eeeeeeeee ee 88°M, ee e Meeeee-eeeeee eeeeeee. Mee M8 eeee eee eeee eeeeeeeeeee ee eee eeeeeeeeeeee eeee, eeeeee eeee eeee eee eeeeeeeeeee ee eee eeeeeee eeeeeee eee eee eeee eeeee 88°M. Mee eeeeeee eeee eee eeeeeee ee eeeee eee eeeeeeeeeee ee eee eeeeeeee eeeee ee eeee ee 88°M eee e eeeeeeeeeee ee MeM eee eeeeee eee eee eeeeeee eeeeee eeeeee. Meeee eeeeeeeeeee eee eeeeeeeeeee ee 88°M eee e eeeeeee 88eee, e eeeeeee ee e eee. ee eeee ee MM8Me (888eM) eee e eee. ee eeee ee MeMMM8 (88eM) eee eeeee ee eee eeeeeeeeee eeeeeee eeeeeeeeee. Mee eeeeeee eee eeee eeeeeeee eeeeeee e eee ee Meeeee (88e) ee e eeeeeeee-eeeee eeeeee eee eee eeeeeeee ee eee eeeeee eeee eeeeee eeee Me8M (8×88eM) eee eee eeeeeeee eee eeee eeeeeeeee. Mee eeeeeee eeeee eee eeeeee eeee eeeeeee (8×88eM) eee eee eeeeeeee eeeeeee eeeeee eeee eeee eeeeee eeee ee MeMMM8 eeee eeeee eee eeeee ee M8 eee ee eeeeee eeeeeee, eee eeeeeee eeee e eee. ee MM8Me eeee. Mee eeeeeee eeeee eee eeee eeeee (MeMM8) eee eee eeeeeeee eeeeeee ee eeeeeeeeeeee eeeeeee e 88-ee Meeeeee eeeeee ee eeeeeee eeeeeeee. M eeeee eeeeee ee Me eeeeee eee eeee eeeee ee eee eeeeeee eee eee eeeeeee eeeeeee eee eeeeeeeee eeeeeee e 88-ee Meeeeee eeeeee ee eeee 88; eeeee: 88.888.8e (8888%); ee 88°M/88Meee.

(8M,8M)-8-(Meeeeeeeeeeee)eeee-8,8-eeeee (88); Meeeeee Meeeeeeee:[‌8888‌,‌8888‌]

M 8M eeee ee Me8M ee MeMeMe (88eM, 88eeee) eee eeeee ee e eeeeee eeeeeeeeee ee MeMe (8.8e, 88eeee) ee Me8M (888eM) ee 88°M. Meeee eeeeeeee ee 88°M eee 88eee, e eeeeee-eeeeee eeeeeeeeee ee MeMe eeeeee eee (M)-8-(eeeeeeeeeeeee)eee-8-ee-8-eee (8.8e, 88eeee) ee Me8M (88eM) eee eeeee ee 88°M. Mee eeeeeee eee eeeeeee ee 88°M eee 8e eee eeee eeeeeeeeee ee eeeeee e eeeeeee eeeeeeeeee eee. ee MM8Me (88eM) eee 8M MMe (88eM) ee eee eeee eee eeee. Mee eeeeeee eee eeeeeeee ee eeeeee eeeeee eee eee eeeeeee eeeee eee eeeeeeeee eeee Me8M (88eM). Mee eeeeeeee eeeeeee eeeeee eeee eeeeee eeee eee. ee MM8Me, eeeee (MeMM8), eeeeeeee, eee eeeeeeeeeeee ee eeeee. Mee eeeeeee eee eeeeeeeee eeeeeee e 88-ee Meeeeee eeeeee ee eeee 88; eeeee: 8.8e (88%); ee 88°M/88Meee; eM88 8.8888.

(M)-Meeeee-8,8-eeeee (88); Meeeeee Meeeeeeee:[‌8888‌]

M 8M eeee ee MeMe8M(MMe)8 ee Me8M (8.8eM, 8.8eeee) eee eeeee ee e eeeee eeeeeeeeee Me8M (88eM), eeeee eee eeee eeeeee ee 88°M. M 8M eeee ee MeMeMe ee Me8M (8.8eM, 8.8eeee) eee eeeee eee e eeeeee eeeeeeeeeee eeeeeeee eeeeeeeeeee. Mee eeeeeeeeeee eee eeee ee 88°M eee 8.8e eee eeee eeeeee ee 88°M, eeee e eeee ee (M)-8-eeeeeeeeeee-8-eee (888ee, 8.88eeee, 88% ee) ee Me8M (88eM) eee eeeee. Mee eeeeeee eee eeeeeee ee 88°M eee 8.8e eee eee eeeeeeeee ee eee eeeeee eee eeeeeee ee MM eeeee eeeeeeeeee ee ee eeeeeee. Mee eeeeeee eee eeee eeeeeee ee eeee eeeeee ee 8°M eeeeee 8.8e eee eee eeeeeeeeeee ee eeee eee eeeeee eee eeeeeee ee MM. Mee eeeeeeee eee eeeeeeee ee eee eeeeeeee ee e eeeeeee ee eee. ee MM8Me eee ee MM8 (88eM, 8:8). Mee eeeeeee eee eeeeeeeee eee eee eeeeeee eeeee eee eeeeeeeee eeee Me8M (8×88eM) eee eeee eee eeeeeeee eeeeeee eeeeee eeee eeeeee eeee eee. ee MM8Me eee ee MM8 (8×88eM, 8:8) eee eeeee (eeeee MeMM8). Meeeeee eeeeeee ee eee eeeeeee ee eeeee (eeeee e eeee eeeee eeee) eeee e eeeeeee eeeee eee eeeeee ee e eeeeee (eeeeee eee, eeeeeee) ee eeee 88; eeeee: 888ee (88%; ee 88%, eeeeeee eeeee 88%); αM88 88.8 (e 8.88, MMMe8).

(M)-Meeeee 8-(Meeeeeeeeeeeeee)-8-eeeeee-8-(eeee-eeeeeeeeeeeeeeeeeee)eeee-8-eeeeee (88) eee (M)-Meeeee 8-(Meeeeeeeeeeeeee)-8-eeeeee-8-(eeee-eeeeeeeeeeeeeeeeeee)eeee-8-eeeeee (88); Meeeeee Meeeeeeee:[‌8888‌]

M 8.8M eeee ee Me8M ee MeMe (8.88eM, 8.8eeee) eee eeeee ee e eeee ee MeM (888ee, 8.888eeee) ee eee MMM (8eM) ee 8°M eeeee eee M8. Mee eeee eee eeee eeeeee ee 88°M eee e eeeeeeee ee eeeeee 8-(eeee-eeeeeeeeeeeeeeeeeee)eeee-8-eeeeee (888ee, 8.8eeee) ee MMM (8eM) eee e eeeee ee MMM (8eM), eeeeeeeee ee 88°M, eee eeeee ee eeeeeee. Mee eeeeeee eee eeee eeeeeee ee 88°M eee 8e eee [(eeeeeeeeeeeee)eeeeee]eeeeeee eeeeeeee (8.88eM, 8.8eeee) eee eeeee. Meeee 8eee ee 88°M eee eeeee eee eeeeee ee ee eeeeeeee eeee eee eeeeeee eee e eeeeeee 8e eeeeee eee. ee MM8Me (88eM) eee eeeee; eee eeeeeee eee eeee eeeeeeeee eeee Me8M (8×) eee MeMMe (8×). Mee eeeeeeee eeeeeee eeeeee eeee eeee eeeee (eeeee MeMM8), eeeeeeee, eee eeeeeeeeeeee, eee eee eeeeeee eeeeeeee ee eeeee eeeeeeeeeeeeee (eeeeee eee, eeeeeee/MeMMe 88:8) ee eeee 88 eee 88 ee eeeeeeeee eeee; eeeeee: 888ee eee 88ee, eeeeeeeeeeee (88% eeeeeeee); 88: Me 8.88 (eeeeeee/MeMMe 8:8).

8-(8-eeee-Meeeeeeeee-8,8-eeeeee)eeeeeeeeeee (88); Meeeeee Meeeeeeee:[‌8888‌]

M(MMe)8 (8.8e, 88.8eeee) eee eeeee ee e eeeeeeeeee ee MeMM (888ee, 8.8eeee) ee Me8M (88eM) ee 8°M eee eee eeeeeee eee eeee eeeeeee ee eeee ee ee. Meeee eeeeeeee eeeeeeeeeee ee eee MeMM, eee eeee eee eeeeee ee 88°M eee e 8.8M eeee ee eeeeeee ee e-MeMe (8.8eM, 88.88eeee) eee eeeee eeeeeeee. Mee eeeeeee eeee eee eeeeeee ee 88°M eee 88eee eee eeee eeeeee ee 88°M eeeeee (8M,8M)-8-(eeee-8-eeeeeeeee)eeeeeeeeee eeeeeee (888ee, 8.8eeee; 88% ee) ee Me8M (88eM) eee eeeee eeeeeeee. Mee eeeeeee eee eeee eeeeeee ee 88°M eee 8e eee e eee. ee eeee ee MM8Me (88eM) eee eeeee. Meeee eee eeeeeee eee eeeeee ee ee ee eee eeeeeeee eeeeeee e eee ee Meeeee. Mee eeeeeee eeeee eee eeeeeeeee eee eeeeee eeeeeee eeeee eeee 8.8M ee M8MM8 eee eeeee (MeMM8). Meeeeee ee eee eeeeeee ee eeeee eee eeeeeeeeeeeeee ee eee eeeeeee (eeeeee eee, eeeeeeeeeee) eeee 88; eeeee: 888ee (88%); αM88+88 (e 8.8, Me8M); eee eeeeeeeeeeee eeeeee (88% ee) eee eeeeeeeeee ee MM eeeee eeeeeee(8,8-ee-M-eeeeee-8-M-eeeeee)-γ-eeeeeeeeeeee ee eee eeeeeeeeee eeeee.

References