Science of Synthesis

Heaney, H.; Christie, S., Science of Synthesis, (2004) 3, 518.

Substitution reactions of alkenylcopper reagents proceed as expected, allowing transfer of the vinylic group to the organic electrophile. Generally, only small quantities of copper catalyst are required and the reaction is conducted at low temperature. This is not strictly necessary, since higher temperatures have been successfully employed, showing that alkenylcoppers are relatively thermally stable. The solvent of choice is generally tetrahydrofuran. Some representative examples, and experimental procedures, are presented here.

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‌Meeeee 888‌ Meeeeeeeeeee ee Meeeeee Meeeeee Meeeee eeee Meeeeee Meeeeeeee Meeeeeeee ee Meeeee(M)[‌8888‌,‌8888‌]

Me eeeeeeee, eeeeeeeeee eeeeee eee ee eeeeeeee ee eeeeee eee eeeee ee eeeeeeeee; eeeeeee eee eeeeeeeeee eeee eee eeeeeeee eeeeeeeeee (‌Meeeee 888‌).[‌8888‌] Meeeeeee eeeeeeee eeeee eeeeeeee ee eeeeeeeee, eeee ee eeeeeeeeeee. M eeeeee eeeeeeeeee ee eee Meeeeeee eee ee eeeee ee eeeeeeeeeee eee eeeeee eeeeeee eeeee.[‌8888‌]

‌Meeeee 888‌ Mee ee Meeeeeeeee Meeeee ee Meeeeeeeeeee Meeeeeee eeee Meeeeee Meeeeeeee Meeeeeeee ee Meeeee(M)[‌8888‌,‌8888‌]

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‌Meeeee 888‌ Meeeeeee ee Meeeeee Meeeeeeee eeee Meeeeeee Meeeeeeee ee Meeeee(M)[‌8888‌–‌8888‌]

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‌Meeeee 888‌ Meeeeeee ee Meeeeee Meeeeeeee eee Meeeeee Meeeeeeeeeee, Meeeeeeee ee Meeeee(M)[‌8888‌,‌8888‌]

Meeeeeeeeeee Meeeeeeee

8-(Meeeeeeee)-8-eeeeeeeeeeeeeeeee-8,8-eeee (‌88‌); Meeeeee Meeeeeeee:[‌8888‌]

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References

Meeeeee Meeeeeeeeee

• 8.Meeeee-Meee, (8888) 8/8e, 888.