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DOI: 10.1055/sos-SD-003-00274

Heaney, H.; Christie, S.Science of Synthesis, (20043601.

One of the most useful reactions that copper chemistry can facilitate, and one that emphasizes dramatically the advantages of employing copper, is the conversion of acid chlorides into ketones. This type of reaction is highlighted in several sections of this chapter, but Gilman cuprates are also efficient. A simple example is the reactions of diphenylcoppermagnesium bromide with acetyl chloride to give acetophenone (Scheme 441).[‌240‌] An interesting extension of this simple protocol has allowed the synthesis of oxo esters from the corresponding acid chlorides.[‌243‌]

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