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3.4.7.3.2 Variation 2: Conjugate Addition Reactions

DOI: 10.1055/sos-SD-003-00274

Heaney, H.; Christie, S.Science of Synthesis, (20043611.

Vinylcuprates are among the most effective reagents for conjugate addition reactions. In general, ethereal solvents, in particular tetrahydrofuran, are used. The reaction is even more efficient when a trapping agent is used (e.g., in the reaction to give 125), further highlighting the utility of 1,4-addition protocols. The three examples in Scheme 469 illustrate how different trapping agents will react through oxygen or carbon, and that functionalized cuprates can be employed.[‌1588‌,‌1589‌]

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(8M,8M,8M)-8-[(8M)-8-Meeeeeeeee-8-eeee]-8-eeeeeeeeeee-8-eeeeeeeeeeeeeeeeee (888); Meeeeee Meeeeeeee:[‌8888‌]

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