0 Hits

  • Previous / Next

You are using Science Of Synthesis as a Guest.
Please login to access the full content or check if you have access via Method 59: Allylation of Aldehydes and Ketones

DOI: 10.1055/sos-SD-004-00909

Sarkar, T. K.Science of Synthesis, (20024905.

Homoallylic alcohols are available by the reactions of allylsilanes with aldehydes or ketones either by prior activation of the carbonyl functionality with a Lewis acid or by prior activation of allylsilane itself with a Lewis base. In some exceptional cases,[‌42‌,‌43‌] no external activation is required; for an illustrative example see Scheme 5. Use of chiral Lewis acids[‌280‌] or chiral Lewis bases[‌281‌,‌282‌] allows asymmetric synthesis of homoallylic alcohols.