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4.4.41.7 Additional Methods

DOI: 10.1055/sos-SD-004-01012

Ian Fleming, Science of Synthesis, (20024943.

Among methods forming the central CC bond (Scheme 17), aldol condensations on acylsilanes result in β-silyl carbonyl compounds, with the Peterson variant (e.g., 6567) probably the best.[‌82‌] The trimethylsilylmethyl Grignard reagent 68 reacts with nitroethenes (e.g., 69) to give the Nef product 70.[‌83‌]

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References