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7.1.9.6 Method 6: Addition to C—C Multiple Bonds

DOI: 10.1055/sos-SD-007-00207

Oishi, M.Science of Synthesis, (20047277.

This section deals with synthetic methodologies utilizing triorganoaluminum compounds, one of whose organo groups transfers to a CC multiple bond. Classically, uncatalyzed processes are based on the significant interplay of the relatively strong Lewis acidity of the aluminum center and Lewis base substrates. Recently, development of transition-metal catalysts with the organoaluminum precursors have led to a high level of control of reaction selectivities and broad application for the syntheses of complex natural products. Many examples described here use Ziegler's aufbau reaction and the concept of alkene polymerization catalysis. This section is classified into four procedures: carbo­alumination, hydroalumination, cyclopropanation, and conjugate addition.


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