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7.1.9.7 Method 7: Addition Reactions to Carbon—Heteroatom Multiple Bonds

DOI: 10.1055/sos-SD-007-00207

Oishi, M.Science of Synthesis, (20047303.

Addition reactions of AlC bonds to CO or CN multiple bonds utilize the intrinsically strong Lewis acidity of the triorganoaluminum reagents. More electrophilic reactions are characteristic and largely differ from those with Grignard and organolithium reagents. Interestingly, the reactivity and product structure using these aluminum reagents can be modulated by varying the ligands and reaction media. Owing to the strong oxophilicity of the aluminum center, reactions with carbonyl substrates will be covered in this section.


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