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7.6.11.2 Method 2: Coupling Reactions Using Nickel–Phosphine Catalysts

DOI: 10.1055/sos-SD-007-00562

Takahashi, T.; Liu, Y.Science of Synthesis, (20047598.

Coupling reactions using Grignard reagents in combination with a nickel catalyst are very useful methods in organic synthesis. The following reaction mechanism is widely accepted for these coupling reactions (Scheme 1).[‌1‌,‌5‌]

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