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Please login to access the full content or check if you have access via7.6.11.2.3 Variation 3: Nickel-Catalyzed Enantioselective Coupling of Grignard Reagents with Allyl Compounds
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Takahashi, T.; Liu, Y., Science of Synthesis, (2004) 7, 600.
There are several chiral phosphines ligands commonly used for the enantioselective coupling of Grignard reagents with allyl compounds: (−)-Diop,[31] (S,S)-Chiraphos,[20,32–36] (R)-Phenphos,[35] (+)-(R,R)-cyclopentane-1,2-diylbis(diphenylphosphine) (Scheme 6),[37] BIPHEMP, MeO-BIPHEP, (S)-BINAP, (S,R)-BPFFA, optically active oxazolinylferrocenylphosphine,[38] and 3,4-bis(diphenylphosphino)pyrrolidine.[39] Among these chiral phosphine ligands, (S,S)-Chiraphos is widely used for the coupling of allyl compounds, giving good results, and in some cases enantiomeric excesses of over 90% are obtained.
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References
| [20] | Meeeee, M.; Meeeeeeee, M. M., Meeeeeeeeee Meee., (8888) 88, 8888. |
| [31] | Meeeeee, M.; Meeeee, M.; Meeeeee, M. M., M. Meee. Mee., Meee. Meeeee., (8888), 888. |
| [32] | Meeee-Meeeee, M.; Meeee, M. M.; Meeeee, M. M.; Meeeeee, M. M.; Meeeeee, M. M., M. Me. Meee. Mee., (8888) 888, 8888. |
| [33] | Meeeeeeee, M.; Meeeeeeee, M.; Meeeeee, M., M. Meee. Mee., Meee. Meeeee., (8888), 888. |
| [34] | Meeeee, M.; Meeeee, M., Meeeeeeeeee Meee., (8888) 88, 8888. |
| [35] | Meeeeeeee, M.; Meeeeee, M.; Meeeeeee, M.; Meeeeeeee, M., Meeeeeeeeee, (8888) 88, 8888. |
| [36] | Meeeeeeee, M.; Meeeeeee, M.; M. Meeeeeeee. Meee., (8888) 888, 88. |
| [37] | Meeeeeeee, M.; Meeeeeee, M., Meeeeeeeeeeeeee, (8888) 88, 8888. |
| [38] | Meeee, M.; Meeeee, M.; Meeeee, M., M. Meee. Mee., Meeeee Meeee. 8, (8888), 8888. |
| [39] | Meeee, M.; Meeeee, M. M., Meeee. Meee. Meee, (8888) 888, 88. |
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- 8.Meeeee-Meee, (8888) M 88-8, 888.
- 8.Meeeee-Meee, (8888) M 88e, 8888.
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