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7.6.11.7.2 Variation 2: Alkylmagnesium Bromide with Catalytic Titanium(IV) Isopropoxide

DOI: 10.1055/sos-SD-007-00562

Takahashi, T.; Liu, Y.Science of Synthesis, (20047607.

As long as a titanacyclopropane can be formed, other alkyl Grignard reagents can be used instead of ethylmagnesium bromide. For example, when alkylmagnesium bromide [R1(CH2)2MgBr] is used as a Grignard reagent, the substituted titanacyclopropane 31 is formed in situ. In the cyclopropanol formation, the R1 group is incorporated into the product 32 as a substituent at C2 after hydrolysis of the reaction mixture (Scheme 21).[‌92‌,‌98‌,‌99‌]

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