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Please login to access the full content or check if you have access via7.6.13.12 Method 12: Reactions Involving Diethyl (Ethoxymagnesio)malonate
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Shimizu, M., Science of Synthesis, (2004) 7, 652.
Diethyl (ethoxymagnesio)malonate (4) (see Section 7.6.13.4) can be acylated by many activated carboxylic acid derivatives and alkyl chloroformates.[11] It is soluble in aprotic solvents such as diethyl ether and benzene, and undergoes exclusive C-acylation. A number of acylmalonates, e.g. 14, have been prepared from diethyl (ethoxymagnesio)malonate (Scheme 12).[39,40] Methyl ketones are prepared from the acyl malonate intermediate following vigorous hydrolysis (Scheme 12).[41] Methanetricarboxylic esters are generally prepared by the reaction of diethyl (ethoxymagnesio)malonate with an alkyl chloroformate.[11] For example, triethyl methanetricarboxylate is obtained in high yield from diethyl (ethoxymagnesio)malonate and ethyl chloroformate.
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Meeeeee Meeeeeeeeeeeeee (88):[88]
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References
[11] | Meeee, M. M.; Meeeeee, M. M., Mee. Meeee., Meee. Mee. MM, (8888), 888. |
[39] | Meeeeee, M. M.; Meeeeee, M. M.; Meeeee, M. M., M. Meeeeeeeee. Meee., (8888) 88, 888. |
[40] | Meeee, M. M. M.; Meeeeeee, M.; Meeeeeee, M., M. Mee. Meee., (8888) 88, 8888. |
[41] | Meeeee, M. M.; Meeeee, M.; Meeee, M.; Meeeee, M.; Meee, M. M.; Meeeeee, M., M. Mee. Meee., (8888) 88, 8888. |
Meeeeee Meeeeeeeeee
- 8.Meeeee-Meee, (8888) 88/8e, 888.