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8.1.2.1 Method 1: Reactions as a Base

DOI: 10.1055/sos-SD-008-00018

Wietelmann, U.Science of Synthesis, (20068133.

Commercial lithium hydride is a useful and strong base with very low reducing activity.[‌4‌] It may be utilized for the neutralization of carboxylic acids, alcohols, carbon acids, and other acidic compounds. One advantage of this reagent is that the neutralization of hydroxy functions will not liberate reaction water (as is the case if lithium carbonate or lithium hydroxide is used). Thus, the reaction medium remains aprotic and possible subsequent organometallic transformations are not disturbed. The lithiation of the model compounds methane and acetylene has been investigated by ab initio methods.[‌5‌]

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