You are using Science Of Synthesis as a Guest.
Please login to access the full content or check if you have access via8.1.17.1.2 Method 2: Regio- and Stereoselective Formation of Lithium Enolates by Indirect Methods
Please login to access the full content or check if you have access via
DOI:
10.1055/sos-SD-008-00312
Caine, D., Science of Synthesis, (2006) 8, 522.
As highlighted in the preceding discussion, by a judicious choice of a lithium amide base and appropriate reaction conditions, it is frequently possible to generate a lithium enolate regioselectively with the desired regio- and stereochemistry by quantitative deprotonation of the corresponding ketone. Nevertheless, a large arsenal of indirect methods for generating specific lithium enolates has been developed.[16–18,27] Because they may offer some distinct advantages for the synthesis of particular α-substituted ketones, a brief description of some of the more important methods of this type is provided below.
References
| [16] | e'Meeeee, M., Meeeeeeeeee, (8888) 88, 8888. |
| [17] | Meeee, M., Me Meeeee-Meeeee Meee Meeeeeeee, Meeeeeeee, M. M., Me.; Meeeee: Mee Meee, (8888); Mee. 8, Meeeeee 8. |
| [18] | Meeeeeeeeee, M. M.; Meeeee, M. M., Me Meeeeeeeeeeee Meeeeee Meeeeeeee, Meeee, M. M.; Meeeeee, M., Mee.; Meeeeeee: Meeeee, (8888); Mee. 8, Meeeeee 8.8. |
| [27] | Meeee, M., Me Meeeeeeeeeeee Meeeeee Meeeeeeee, Meeee, M. M.; Meeeeee, M., Mee.; Meeeeeee: Meeeee, (8888); Mee. 8, Meeeeee 8.8. |
Meeeeee Meeeeeeeeee
- 8.Meeeee-Meee, (8888) M 88e, 888.
Return to Top