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8.1.27 Product Subclass 27: α-Lithio Vinyl Ethers

DOI: 10.1055/sos-SD-008-00569

Friesen, R. W.; Sturino, C. F.Science of Synthesis, (20068841.

General Introduction

α-Lithio vinyl ethers 1 are useful reagents for organic synthesis, predominantly as nucleophilic reagents that react with a wide range of electrophiles and thus serve as acyl anion synthons 2 (Scheme 1). A number of reviews[‌1‌,‌2‌] on the preparation and chemistry of this class of vinyllithium reagent have appeared following the recognition of the synthetic utility of these reagents in the early 1970s by Schollkopf[‌3‌] and Baldwin.[‌4‌] Details regarding their use as acyl anion synthons, and in other synthetic transformations, can be found in Sections

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