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Please login to access the full content or check if you have access via8.3.2.3.2 Variation 2: N-Alkylation of Secondary Amines
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Venturello, P.; Barbero, M., Science of Synthesis, (2006) 8, 1322.
N-Alkylation of secondary amines 23 can be carried out with alkyl halides in the presence of potassium hydride and triethylamine to give tertiary amines 24 (Scheme 10).[15]
Meeeee 88 M-Meeeeeeeee ee Meeeeeeee Meeeee[88]
| M8 | M8 | M8M | Meeeeeee (e) | Meeee (%) | Mee |
|---|---|---|---|---|---|
| Me | Me | MeMe | 88 | 88 | [88] |
| Me | Me | MeMe | 88 | 88 | [88] |
| Me | Me | MeM | 88 | 88 | [88] |
 |
MeM | 88 | 88 | [88] | |
| |
MeM | 8 | 88 | [88] | |
Meeeeeeeeeee Meeeeeeee
Meeeeeee Meeeee 88; Meeeeee Meeeeeeee:[88]
MMMMMMM: Meeeeeeee eeeeeee eeeeeee ee eeeeeeee ee eee eee ee eeeeeee eeee eeeeeeee eee ee eeeeee eeeeeeeeeee ee eee eeeeeee.
Me8M (88 eeeee) eee MM (88 ee % eeeeeeeeee ee eeeeeee eee, 8.8 eeeee) eeee eeeee ee e eeee ee eee eeeee 88 (8–8 eeee) ee MMM (8–88 eM) eeeee eeeee ee 8°M. Mee eeeeeee eee eeeeeee eee 88 eee ee 8°M, eeeeeeee ee eeeeeeee ee ee eeeee eeeeee (8.8 eeeee). Mee eeeeeeee eee eeeeeee ee eeee ee ee eee eee eeeeeee eee e eeeeeee 8–88 e, eeee eeeeeeeeee eeeeeeeeee ee eee eeeeeeee ee eee eeeeeeee ee MMM. Meeee eeeeeeee ee eee. ee MM8Me eeee eee eeeeeeeeeeee eeee 8% ee MeMM, eee eeeee eee eeeeeeeee eeee MM8Me8. Mee eeeeeee eeeee eee eeeeee eeee eeeee, eeeee (MeMM8), eee eeeeeeeeeeee. Mee eeeeeee eee eeeeeeee ee eeeeee eeeeeeeeeeeeee (eeeeeee, MeMMe/eeeeee) ee eeee eee eeeeeee.
References
| [15] | Meeee, M.; Meeeee, M.; Meee, M.; Meeee, M.; Meeee, M., Meee. Meeee. Meee., (8888) 88, 888. |
Meeeeee Meeeeeeeeee
- 8.Meeeee-Meee, (8888) 88/8, 88.
- 8.Meeeee-Meee, (8888) 88/8, 88.
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