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8.3.6.18.4 Variation 4: Nucleophilic Aromatic Substitution Reactions of (Fluorophenyl)dihydroimidazoles with Phosphides

DOI: 10.1055/sos-SD-008-01221

Venturello, P.; Barbero, M.Science of Synthesis, (200681434.

The BoehringerIngelheim phosphinodihydroimidazole (BIPI) ligands 91 can be synthesized by the reaction of (fluorophenyl)dihydroimidazoles 90 with potassium diphenylphosphide (Scheme 47). To explore electronic effects in asymmetric catalysis, these ligands can be tuned in three different regions by changing the Ar1, R1, and R2 substituents.[‌60‌]

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