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You are using Science Of Synthesis as a Guest.
Please login or sign up for a free trial to access the full content. Method 5: Introduction of Chloromethyl and Hydroxymethyl Groups

DOI: 10.1055/sos-SD-009-00244

König, B.Science of Synthesis, (20019243.

The reaction of furans 273, 275, or 277 with formaldehyde and dry hydrochloric acid in the presence of zinc(II) chloride or other catalysts introduces a chloromethyl group (compounds 274, 276, and 278; Scheme 90).[‌506‌‌510‌] The method is of limited use for the synthesis of functionalized furans because of their sensitivity towards acids.

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