Navigation

0 Hits

  • Previous / Next

You are using Science Of Synthesis as a Guest.
Please login or sign up for a free trial to access the full content.
9.9.4.1.5 Method 5: Introduction of Chloromethyl and Hydroxymethyl Groups

DOI: 10.1055/sos-SD-009-00244

König, B.Science of Synthesis, (20019243.

The reaction of furans 273, 275, or 277 with formaldehyde and dry hydrochloric acid in the presence of zinc(II) chloride or other catalysts introduces a chloromethyl group (compounds 274, 276, and 278; Scheme 90).[‌506‌‌510‌] The method is of limited use for the synthesis of functionalized furans because of their sensitivity towards acids.

Mee eeeeeeeee eeeeeeee ee eeeeee 888 eee eeeeeeeeeeee eeeeeee eeeeeeeeeeee eeee eeeeee eeeeeeeeeeeee eeeeeeeeeee 888 (Meeeee 88).[‌888‌]

Meeeee 88 Meeeeeeeeeeeeeeee ee Meeeee[‌888‌‌888‌]

Meeeee 88 Meeeeeeeeeeeeeeeee ee Meeeee[‌888‌]

References