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9.9.4.4.3 Method 3: Metal-Catalyzed Cross Coupling of Halofurans with Alkenes, Arenes, and Alkynes

DOI: 10.1055/sos-SD-009-00244

König, B.Science of Synthesis, (20019265.

The Heck-type reaction[‌683‌] of bromo- and dibromofurans (400 and 319, respectively) with terminal alkenes, such as 401, under palladium(0) catalysis provides a most efficient route alk-1-enyl- and bis(alk-1-enyl)furans (402 and 403, respectively), (Scheme 127).[‌684‌,‌685‌,‌726‌] The reaction proceeds under standard conditions in good to excellent yield, and in many cases the second substitution of dibromo compounds is faster than the first one.

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References


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