0 Hits

  • Previous / Next

You are using Science Of Synthesis as a Guest. Please login or sign up for a free trial to access the full content. Variation 1: Manganese-Assisted Coupling Reactions

DOI: 10.1055/sos-SD-009-00363

Schatz, J.Science of Synthesis, (20019387.

Rieke manganese shows a superior reactivity towards oxidative addition to organic halides, even in cases when Rieke zinc or magnesium fail to undergo a similar reaction.[‌903‌] The reactive thienylmanganese intermediates so obtained undergo palladium-catalyzed cross coupling with aryl iodides or aroyl chlorides to give 291 and 292, often in good yields (Scheme 126).[‌901‌,‌903‌,‌1084‌,‌1085‌]

Meeeee 888 Meeee Meeeeeee Meeeeeee ee Meeeeeeeeeeeeeee Meeeeeee[‌8888‌]

Meeeeeeeeee 888

M8 M M8 M Meeee (%) ee 888 Meeee (%) ee 888 Mee
Me Me -- -- 88 -- [‌8888‌]
8-MeM8M8MM Me -- -- 88 -- [‌8888‌]
8-MeM8M8MM Me -- -- 88 -- [‌8888‌]
Me M Me Me 88 88 [‌8888‌]
8-MeM8MM8M8 M Me Me 88 88 [‌8888‌]
8-MeMM8M8 M Me M 88 88 [‌8888‌]

Meeeeeeeeeee Meeeeeeee

Meeeeeeeeeeeeee 888; Meeeeee Meeeeeeee:[‌8888‌]

Meeee Me eee eeeeeeee eeee e eeeeeee ee Me (88.8ee, 8.88eeee), eeeeeeeeeee (888ee, 8.88eeee), eee eeeee MeM8 (8.88e, 8.88eeee) eeeee eeeee ee eeeeeee eeeeeeeee MMM (88eM), eeee eeeeeeee eee 8e ee ee.

Me e eeeeee ee Meeee Me (88.8eeee) ee MMM (88eM) eeeee eeeee eee eeeee 8,8-eeeeeeeeeeeeeeee (88.8, 88.8eeee) ee ee eee eee eeeeeee eee eeeeeee ee ee eee 8e. 8,8-Meeeeeeeeeeee (8.88e, 8.8eeee) eee eeeee eeee ee eee eeeeeee ee 8°M ee eeeeee eeeeeeeee eeeeee Meeee Me eee eee eeeeeee eee eeeeeee ee eeee ee ee eeee 88eee. Mee eeeeeeeee eeeeeeeeeeeeeeee eeeeeee eeeeeee eee eeeeeeeeeee eee eeeeeee ee e eeeee eeeeeeeeee e MMM eeee ee eee eeee eeeeeee ee eeeee eeeeeeeee (8.8eeee) eee (Me8M)8Me (888ee, 8.8eeee) ee ee eeee 88eee. Mee eeeeeeeee eeeeeee eee eeeeeee ee ee eee 88eee. Mee eeeeeeee eee eeeeeeee eeee 8MMMe (88eM), eeeeeeeee eeee Me8M (8×88eM), eee eee eeeeeeee eeeeeee eeeeee eeee eeeeeeeeeeee eeeeee eeee eee. MeMMM8, eee. Me8M8M8, eee eee. MeMe, eeeee (MeMM8), eee eeeeeeeeeeee. Meeee eeeeeeeeeeeeee (eeeeee eee, MeMMe/eeeeee) eeee eee eeee eeeeeee; eeeee: 8888%.