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10.13.1.4.2.1.1.5.6 Variation 6: Introduction of Alkyl Groups

DOI: 10.1055/sos-SD-010-00559

Joule, J. A.Science of Synthesis, (200110523.

Indoles do not react with simple alkyl halides at room temperature; 1H-indole itself reacts with iodomethane in dimethylformamide at about 80°C when the main product is 3-methyl-1H-indole (skatole), but alkylation of indoles with simple alkyl halides is not a useful synthetic process. However, more electrophilic alkylating electrophiles react at lower temperatures, e.g. dimethylallyl bromide reacts at room temperature[‌784‌] but with 1H-indole itself mixtures are obtained.[‌785‌] Conditions can be chosen such that 3-substituted indoles will react with this halide to give 3,3-disubstituted 3H-indoles in which one of the 3-substituents is the allyl group[‌541‌] or to give 2-allylated products cleanly.[‌786‌] Other halides reactive enough to attack indoles at C3 include 2-hydroxybenzyl halides[‌787‌,‌788‌] and trityl chloride in hot toluene.[‌789‌]

Meeeeeeeee ee 8-eeeeeeeeeeeee eeeeeee eeee α-eeeee eeeeeee ee α-eeeeeee eeeeeee (e.e., ee eeee 888, Meeeee 888),[‌888‌] ee eeeeeee eeee 8-eeeeeeeeeeeeeeeeeee,[‌888‌] eee 8-eeeeeeeeeeeeee ee eeeeeee eeeeeeeeeeee eeeeeeee 888 eeeee eee ee eeeeeeeeee ee 8M-eeeeee-8-eeeeeeeeeeee (Meeeee 888),[‌888‌] eeee eeee eeee eeeee ee ee eeeeeeeeeeeee eeeeee eeeeeeeee. Meeeee 888 eeeee eee eeeeee ee eeeee 8-eeeeeeeeeeeeeeeeeee (888) eeee eeeeee 8M-eeeeee-8-eeeeeeeeeee (888) eeeee eeeeeee eeeeeeee eeeee ee e 8-eeeeee-eeeee eeeeee 888.[‌888‌]

Meeeee 888 Meeeeeee ee α-Meeeeee Meeeeee eeee 8M-Meeeee[‌888‌,‌888‌]

Meeeee 888 Meeeeeee ee 8M-Meeeee eeee e 8-Meeeeeeeeeeee[‌888‌]

Meeeee 888 8-Meeeeeeeeeeee Meeeeeeeeeee ee ee Meeeee-8-eeeeeeeeeee eeee ee α-Meeeee Meeeee[‌888‌]

Meeeeeeee eeeeeeee eee ee eeeeeeeee ee eeeeeeee eeeeeeeeeeee eee eeee eeeee eeeee 8-eeeeeeeeeeeeee ee eeeeeee, e.e. 8-eeeeeeeeeeeeee ee 8M-eeeeee (8) ee eeee 888 (Meeeee 888).[‌888‌,‌888‌]

Meeeee 888 8-Meeeeeeeeeee ee 8M-Meeeee eeee 8-Meeeeeeee-8-ee-8-ee eeee e Meeeee Meeeeeee[‌888‌,‌888‌]

Meeeeee eeeeeeee eeeeee 8-eeeeeeeeee ee eee eeeeeeee ee eeeeeee eeeeeeeeeee, ee eeeeeeeeeee ee eee eeeeeeeee ee 888 eeee eee eeeeeeee ee eeeeeee eeeeeee 888 eeee 8M-eeeeee (8) ee Meeeee 888.[‌888‌]

Meeeee 888 8-Meeeeeeeeeee ee 8M-Meeeee eeee ee Meeee Meeeeee eeee Meeeeee Meeeeeeeeee[‌888‌]

Meeeeeee eeee eeeeeee eeeeeee 888 eeeeeeeee ee eeeeeeee(MM) eeeeeeee eeee eeeeee 8M-eeeeee-8-eeeeeeeeeee (888) eeeee 888; eeee eee eeeeeee eeeee ee eeeeeeeee ee eeeeee eeee eee eeeeee ee eeeeeee ee ee eeeee eeee (Meeeee 888).[‌888‌]

Meeeee 888 8-Meeeeeeeeeee ee Meeeee 8M-Meeeee-8-eeeeeeeeeee eeee e Meeeeee Meeeeee[‌888‌]

Meee eeeeeeeee eeeeeeee, eeeeeeeee α-eeeeeee eeeeeee[‌888‌,‌888‌] eeeeeeee eeeeeee ee eeeeeeee ee eee eeeeeeee ee eeeee eeeeeeeeeee,[‌888‌] ee ee eee eeeeee eeee[‌888‌] ee ee eeee eeeeeeeeeee ee eeeeee eeee eeee eeeeeeeee ee eeeeeeeeee eeee, e.e. eeeeee 888 (Meeeee 888).[‌888‌] Meeeeeeeeeee-8-eeeeeeeeee ee eeeeeeee eeeeee ee eeeeeeee 8-eeeeee-8M-eeeeee ee M8 ee eeeeee eeeeeeeee ee eeeeeee.[‌888‌]

Meeeeeee[‌888‌] eeee eeeeeeee ee M8; eee eee ee eeeeeeeeeeeee/eeeeeeee eeeeeeeeeee/888°M eeee 8,8-eeeeeeee-8M-eeeeee, eeeeeeeeeee e eeeeeeeee eeee eeee eeeee, ee eee eeeeeee.[‌888‌]

Meeeeee eeeee eeee eeeeeeee eeeee eeee ee Meeee eeee eeeeeeeee; eee eeeeeeeee ee 888 eeeeeeeeeee eee eeeeeeeeeeee ee e 8-eeeeeeeeeeee eeee eeeee (Meeeee 888).[‌888‌‌888‌] Meeeeee eeeeee eeeee ee eeeeee eee ee 88 eeee ee 88°M eeee eeeeeee ee eee eeeeeeee eeeeeeee ee eeee eeeeee.[‌888‌] Meeeeeeee(MMM) eeeeeeee ee 88 eeee ee 88°M eeee eeeeee eeeee eee eeeeeeee ee eeeeeee eeee eeeeeeee ee M8.[‌888‌]

Meeeee 888 Meeeeeee ee Meeeee Meeeeee-8-eeeeeeeeeee eeee 8M-Meeeee ee eeee Meeeee 8-Meeeeee-8-(8M-eeeee-8-ee)eeeeeeeeee [‌888‌‌888‌]

Meeeeeee ee eeeeeee eeee eeeeeeeeee, eeeee Meeee eeee eeeeeeeee ee eeeeeeeeee eee eeeeee, eeeee ee 8M-eeeeee-8-eeeeeeeeeee, eeee ee, eeeeeeeeeee. Meee eeeeeeee ee eee eeeeeeee ee eeeeeee eeee eeeeeeeeee eeeeeee eeeeeeeeee eeee ee eeeeeeee-eeeeeeeeeee eeeee ee eee eeeeeeeee eeeeeeee ee eeeeeeeeee eee eeeeee eee eeeeeeeee eeee eeeeeee, eee eeee eeee eeeeeee eeee M-eeeeeeeee eeeeeeeeee eeee eeeeee, eeeeeee eee eee ee eeeeeeeeeee eeeeeeeeeeeeeeeee eeeeeeeeee eee eeeeeeeeee eeeeeeeeee eeee eeeee eeeeeeee, Meeeee 888 eeeee eee eeeeeeeeee ee 8-eeeee-8M-eeeeee (888) eeee 888.[‌888‌,‌888‌]

Meeeee 888 8-Meeeeeeeeeee ee 8-Meeee-8M-eeeeee eeee ee Meeeeeeeeee Meee[‌888‌,‌888‌]

Me eee eeee ee eeeeee eeeeeeee eee eeeeeeeeee, eeee eeeeeeeeeeeeeeeee ee eeeeeeee[‌888‌‌888‌] ee eeeeeeeeeee ee eee eeeeeeeee ee 888 eee 888 ee Meeeeee 888[‌888‌] eee 888.[‌888‌]

Meeeee 888 8-Meeeeeeeeeee ee 8M-Meeeee eeee ee Meeeeee[‌888‌]

Meeeee 888 8-Meeeeeeeeeee ee 8M-Meeeee eeee e Meeeeeeeeeeeeeeee-Meeeeeeee Meeeeeeee[‌888‌]

Meeeeee eeeeeeeee ee eeeeeeeeee eeeeeeee-eeeeeeeeeee eeeeeeeeeeee eeee eeeeeeee eeeeeee; ee eeeeee eeeeeeee, 8M-eeeeee eeeeee eeee eeeeee eeeee eeeeee, eee eeeeee eeeeeeeeeeeee eeeeeee eeeee eeeeeeee ee eeeeeeeeeee eeee eee eeee eeeeeee ee eee eeeeee,[‌888‌] ee eeee eeeeeeeeee ee eee eeeeee eeee.[‌888‌] Mee eee ee Meeeeeeeeeeeeee eeee ee ee eeeeee eeeeeeee ee eeee eeeeeeeee, eeeeee 8-(8M-eeeee-8-ee)eeeeee-8-eee (888) eee eeeeeee (Meeeee 888).[‌888‌] Meeeeee eeee eeeeeeeee eeeeeeee eee eee eeeeeeeeee ee eeeeeee eeee eeeeeeeeeee eeeeeee ee eeeeeeeee(MMM) eeeeeeee,[‌888‌] eeeeee eeee eeeeeeeeeee eeeeee eeeeee eeeeeeeeee eee ee eeee, eeeeeeeeee ee eeeeeee eeeeeeeeee[‌888‌,‌888‌] ee eeeee ee eee eeeeeeeeee ee 888 eeee 888 ee Meeeee 888.[‌888‌]

Meeeee 888 Meeeeeee ee Meeee Meeee Meeeee eeee 8M-Meeeee Meeee Meeeeeeeeeeeeee Meee[‌888‌]

Meeeee 888 Meeeeeeeeeeeee 8-Meeeeeeeee ee ee Meeeee eeee e Meeeeeeeee Meeeeeeeee Meeeee[‌888‌]

Meeeeeeeeeee eee eeeeeeeeeeee eeeeeeeeeeeee ee eeeeeeeeee 8M-eeeeee eeeeeee eee eeee eee eeee eeeeeeeee, eee eee eeeeeee 888 ee Meeeee 888.[‌888‌,‌888‌] 8-Meeeeee-8-eeeeeeeeeee ee eeee ee e eeeeeeeeee eeeeee ee eeeeeeeeeee, eeeeeeeee ee eeee ee eeeeeee, eeee, eee eeeeeee eeeeeeeee eee eeeee eee eee eeeeeeeeee ee 8-eeeeeee-8M-eeeeee (888) eeee eee 8-(8-eeeeeeeeee) eeeeeeeeee 888 (Meeeee 888).[‌888‌,‌888‌]

Meeeee 888 Meeeeeee ee 8-Meeeeeeeeeee eeee 8M-Meeeee[‌888‌,‌888‌]

Meeeee 888 8-Meeeeeeeeeee ee 8-Meeeeee-8M-eeeeee eeee Meeeeeeeeee[‌888‌,‌888‌]

Mee eeeeeeeee ee eeeeeee eeee eeeeeeeee eee Meeeeee'e eeee 888 eeeeeeee eeeeeee eeeeeee eeeeeee eeeeeeeeeeee ee eee eeeeeeee eeee Meeeeee'e eeee, eeee eeeeeeeeee e eeeeeeeeee eeeeee eeeee ee eee eeeeeeeeeeee eeeee eeeeeee eee eeeeee, eeeeeee 888 ee eee eeeeeee eeeee (Meeeee 888).[‌888‌,‌888‌]

Meeeee 888 8-Meeeeeeeeeee ee 8M-Meeeee eeee ee Meeeeeeeee Meeeeee'e Meee[‌888‌,‌888‌]

8-Meeeeeeeeeeeeeee eeee (888) ee e eeeeeee ee eeeeee eeee eee eeeeee eeeeeeeee eeee eeeeee ee eeeeeeee ee eee eeeeee 8-eeeeeeee, eeeeee M-eeeeeeeeeeeeeeee (888); eeee eee eeeeeeee eeee eee eeeeeee ee eee eeeeeee ee eee eeeeee eeeeeeeee ee eeeeeeeeeee ee eeeeeee eeee eeeeeeeee 888 ee eee eeeeeeeeeeee, eeeee eeeeeee eee eeeeee, eeeeeeee ee eeeeeeeeee eeee (Meeeee 888).[‌888‌]

Meeeee 888 8-Meeeeeeeeeee ee 8M-Meeeee eeee ee Meeeeeeee[‌888‌]

Meeeeeee ee M,M-eeeeeeee-8-eeeeeeeeeeeeeee (888) eeee 8M-eeeeee (8) ee eeeeeeeeeeeeeee eeee eeeee ee 8-(8-eeeeeeeeee)-8M-eeeeee (888);[‌888‌,‌888‌,‌888‌] ee eee eeeee eeee eee eeeeeeeeeeeee eeeeeee 888 ee eee eeeeeeeeee eeeeeee, eee eeeeeee ee eeeeeeeee ee e Meeeeee eeeeeeeeeeee (Meeeee 888). 8-Meeeeeeeeeeeeeeeee ee 88% eeeeeeeeeee eeee eeeeee ee ee eeeeeeeee eeeeeee.[‌888‌]

Meeeee 888 8-Meeeeeeeeeee ee 8M-Meeeee eeee M,M-Meeeeeee-8-eeeeeeeeeeeeeee ee Meee[‌888‌,‌888‌,‌888‌]

Meeeee 8-eeeeee-8-eeeeeeeeeeeee (888) ee eeeeeee eeeeeeeeeeeee eeeeee eeeee eeeeee eeeee eeeeeeeeeeee ee eeee eeeeeeeeeee, eeeeeeeee ee eee eeeeee eeeeeeeeeeee ee eee eeeeeeee ee e eeeeeeeeeeeeeeeee eeee eeeee eeee 8-eeeeee-8M-eeeeee (888) ee eee eeeeeee eeeee, eeeeee eee eeeee eeeeeeeeee 888 eeeee ee eeeeeee eee eeeeeeeeee ee eeee 888 (Meeeee 888).[‌888‌,‌888‌]

Meeeee 888 8-Meeeeeeeeeee ee 8-Meeeee-8M-eeeeee eeee Meeeee 8-Meeeee-8-eeeeeeeeeeeee[‌888‌,‌888‌]

Meeeeee eeeeeee eeeee eeeeee eeeeeeeeee eee eee eeeee ee eee eeeeeeeeee eeee eeeee ee eee eeee eeeeeee eeeeeeeeeeee eeeee 888 ee e eeeeee eeeeeeeeeeeeee (Meeeee 888); eeeeeeee eeeeeeeeeee, eeeeeeeeeeeeeee, eee eeeeeeeeeeeee eeeeeeee eee eeee ee eeeee eeeee eeeeeeee ee eeeeeee 888 eeeeeeeee 888.[‌888‌,‌888‌]

Meeeee 888 8-Meeeeeeeeeee ee ee Meeeee eeee e Meeeeeeeeeeeee Meeeeee[‌888‌,‌888‌]

Meeeeeeeeeeeeeee eeeeee eeee 8M-eeeeee (8) ee M8 ee eeee 888 (Meeeee 888).[‌888‌] Meeeeeeee eeee eeeeeeee ee eee eeeeeeee ee eeeeeeeeeeee eeeeeeeeeeee eeee eeee ee MM eeeeeee, eee eeeeeee eeee eeeee-8,8-eeeeeee ee M8 ee eee eeeeeee ee eeee eeeee-8,8-eeeeeeee ee M8, eeeeee eeee ee eee eeeeee.[‌888‌]

Meeeee 888 Meeeeeee ee 8M-Meeeee eeee Meeeeeeeeeeeeeee[‌888‌]

Meeeeeee ee 8-eeeeee-8M-eeeeee eeee 8- ee 8-eeeeeeeeeeeeee ee M8 ee eeeeeeeee ee eee eeeeee eeee eee eeeee ee eee Meeeeee-eeee eeeeeeee ee eee eeeeee ee eee eeeeeeee eeee-eeeee eeeeee eeee; Meeeee 888 eeeee eee eeeeeee 888 eeee 8-eeeeeeeeeeeee (888) eee 8-eeeeee-8M-eeeeee (888).[‌888‌,‌888‌]

Meeeee 888 Meeeeeee ee 8-Meeeee-8M-eeeeee eeee 8-Meeeeeeeeeeee ee Meee[‌888‌,‌888‌]

Me eee eeeeeeee ee eeee, 8-eeeeeeeeeee 888 eeee eeeeeeee eeeeeee eeeeeeeeee, ee eeee, eeeeeeeeee eeeeeeeeeeeeee 888. Meee, eeeeeeee ee 8-eeeeeeeeeee eeeeeee 888 eeee eeeee 8-eeeeeeeeeeeeeee (888) eeeeeeeee ee eeee,[‌888‌] eeee eeeeeeeee,[‌888‌,‌888‌] eeeeee eee eeeeeee eeeeeeeeeeee ee eee eeeeeee eeeeeeeeee eeee eeeee eeeeee 888 (Meeeee 888).

Meeeee 888 8-Meeeeeeeeeee ee e 8-Meeeeeeeeee Meeeee eeee e Meeeeeeeee Meeeeeeeeeeee[‌888‌,‌888‌,‌888‌]

Meeeeeee ee 8-eeeeeeeeeeee 888 eeee eeeeeeeeeeeee 888 eeeeeeeee eeeeeeeeeee eeee eee eeeee eeeeee, eeeee 88 eeee eeeeeeee eeee eeeeeeeee(MMM) eeeeeeee ee eeeeeeee, eeeee ee eeeeeeee 888 ee eeeeeeeeeeee ee M8 (Meeeee 888).[‌888‌]

Meeeee 888 8-Meeeeeeeeeee ee ee Meeeee eeee e Meeeeeeeeeee[‌888‌]

Mee(eeeeeeeeeeeeeee)-eeeeeeeeeee eeeeeeee 888 eeeee eeeee eeeeeeeeeeee (888) ee 8M-eeeeee (8), eee eeeeeeeeeeeeeeee (Meeeee 888).[‌888‌]

Meeeee 888 8-Meeeeeeeeeee ee 8M-Meeeee eeee e Meeeeee[‌888‌]

Meeeeeeeeeee Meeeeeeee

8-(8-Meeeeee-8-eeeeee-8M-eeeee-8-ee)eeeeeee; Meeeeee Meeeeeeee:[‌888‌]

8-Meeeeee-8-eeeeee-8M-eeeeee (88.8e, 8.8eee) eee eeeeeeeeeeee (88.8e, 8.88eee) eeee eeeeee eeeeeeee ee e eeeeeee ee MeMM (888eM) eee 8.88M M8MM8 (888eM) eee 88eee. Mee eeeeee eeeeeee eee eeeeee eeee e eeeeeee ee eee (8.8M) eee ee MM8 (888eM) eee eee eeeeeee eeeeeeeee eeee MeMMe, eeeee eee eeeee eee eeeeeeeeee ee eeee eee eeeeeee ee ee eee; eeeee: 8.8e (88%).

8-[8-(8-Meeeee-8M-eeeee-8-ee)-8-eeeeeeeeeeeeeeee]eeeeeeeeeeeee; Meeeeee Meeeeeeee:[‌888‌]

Me8M (8.8e, 88eeee) eee eeeee ee 8-(8-eeeee-8-eeeeeeeeeeeeeeee)eeeeeeeeeeeee (8.88e, 88eeee) eee 8-eeeeee-8M-eeeeee (8.8e, 88eeee) ee eeeee MMMe8 (888eM) eee eee eeeeeee eeeeee ee eeeeee eee 8.8e. Meeee eeeeeeeeeee ee eee eeeeeee, MeMM/M8M (8:8) eee eeeee eee eeeee eeeeeee eeeeeeeee ee ee, eee eeeeeee eee eeeeeeee eee eee eeeeeeeeeeeeee (MeMM) ee eeee eee eeeeeee; eeeee: 8.8e (88%); ee 888888°M.

Meeeee 8-(8-Meeeeeeee-8-eeee)-8M-eeeeee-8-eeeeeee; Meeeeee Meeeeeeee:[‌888‌]

Me eeeeee 8M-eeeeee-8-eeeeeee (8.88e, 8eeee) ee e eeeeeee ee MeMM, MeMMe eee M8M, 8-eeeee-8-eeeeeeeee-8-eee (8.88e, 8eeee) eee eeeee eeeeeeee eeee eeeeeeee ee ee. Meeee e eeeeeee 8e eee eeeeeee eee eeeeee eeee M8M (888eM) eee Me8M eeee ee eeeeeee eee eeeeeee. Mee eeeeeeee eeeeeee eee eeeeee eeee M8M, eeee eee. ee MeMMM8 eeee eeeee eee eeeeeeeeee. Meeeeeeeeee eeeee eeeeeeeeeeeeee (eeeeee eee, eeeeee/MeMMe 8:8) eeee eee eeeeeee; eeeee: 8.888e (88%).

8M-Meeeee-8-eeeeeee (Meeeeeeeee); Meeeeee Meeeeeeee:[‌888‌]

Meeeeee eee eeeeeee eeee e eeee ee 8M-eeeeee (8.88e, 88eeee) ee MeMM/Me8M (8:8, 88eM) eeee eee eeeeeee eeeeee ee 88°M eee 88e. Meeee e eeeeeee 88e ee ee, M8M eee eeeee eee eeeeeee eeeeeeee eeeeeeeee eeee Me8M. Mee eeeeee eee eeeee eeeeeee eee eeeeeeeeee ee eeee eeeeeeee eeeee eee eeeeeeee ee eeeeeeeeeeeeee (eeeeeee, eeeeeee) ee eeeee, eeeee eeeeeeeee eeeeee (8.88e), eee eeee eeeeeeeeee; eeeee: 8.88e (88%).

Meeeee 8-Meeeeee-8-(8M-eeeee-8-ee)eeeeeeeeee (888); Meeeeee Meeeeeeee:[‌888‌]

8M-Meeeee (8; 8.8e, 88eeee) eee eeeeee eeeeeee-8-eeeeeeeeeee (8.8e, 88.8eeee) eeee eeeeeeeee ee MMe8 eeee MeMe8 (8.8eM, 88.8eeee) eee eeeee eeeeeeee ee 8°M eeee 88eee. Meeee e eeeeeee 88eee ee 8°M, eee eeeeeee eee eeeeeeeeeee eeeeeee 88% ee MeMMM8 (888eM) eee MMMe8 (888eM). Meeeeeeeee, eeee ee-eeeeeeeeee ee eee eeeee eeeee eeee MMMe8 (88eM), eeeeee eee eeeeeee eeeeeeee (MeMM8) eee eeeeeeeeeee eeee eeeee eeeeeeee eeeee eee eeeeeeee ee eeeeeeeeeeeeee (eeeeee eee, Me8M/eeeeeeeee eeeee) ee eeee eeeeeeeee 8M-eeeeee (8.8e) eee eeee eee eeeeeee; eeeee: 8.88e (88%); ee 88°M.

8-(8M-Meeee-8-ee)-8-eeeeeeeeeeeee; Meeeeee Meeeeeeee:[‌888‌]

8M-Meeeee (888ee, 8eeee) eee eeeeeee eeeee (888ee, 8eeee) eeeeeeeee ee MeMM (8eM) ee e Meeeee-eeeeee eeeeeeee eeeeee, eeee eeeeee ee 88°M eeeee 88 eeee eee 88e. Meeeeeeeeee eeeee eeeeeeeeeeeeeee eeeeeeeeeeee (eeeeee eee, eeeeee/MeMMe 8:8) eeee eee eeeeeee; eeeee: 888ee (88%); ee 888888.8°M.

8-Meeee-8M-eeeeee-8-eeeeeeeeee (8-Meeeeeeeeeeeeee, 888); Meeeeee Meeeeeeee:[‌888‌]

Meeeeeeeeee eeeeeeeeeeeeeeeee (8.88e, 8.88eeee) eee eeeee ee eeeeeeee ee 8-eeeee-8M-eeeeee (888; 8.888e, 8.88eeee) ee 888°M. Meeee 8e eee eeeee eeee eee eeeeeeee eeee M8M (88eM). Meeeeeee ee MMM (8e) eeeeeeeee eee eeeee eeeee eee eeeeeeeee eeee MeMMe. Meeeeeeeeeeeeee eeeeeeeeeeee (eeeeee eee) ee eee eeeeeee eeeeeeee eeee eeeeeeee eeeee MeMM/ee MM8/MMMe8 eeee 8-eeeee-8M-eeeeee (888; 8.88e) eee eeee 8-eeeeeeeeeeeeeee 888 ee e eeeeeeee eeeee eeeee; eeeee: 8.88e (88%); ee (eeeeeeeeeeeee) 888888°M (eee).

8-(8M-Meeee-8-ee)eeeee-8-eee; Meeeeee Meeeeeeee:[‌888‌]

8M-Meeeee (8.8e, 8.88eeee) eee eeeeee eeeee eeeeee (8.8e, 8.8eeee) eeeeeeeee ee MM8Me8 (88eM) eeee eeeeee ee eeeeee eeee Meeeeeeeeeeeeee eeee (8.8e) eee 8e. Meeeeeeeee eee eeeeeeeeeee eeee, eeeeeeeee eeeeeeeeeeeeeee eeee eeeeeeeee eeeee/eeeeeee, eee eeeeeee; eeeee: 8.8e (88%); ee 8888°M.

8-(8-Meeeee-8M-eeeee-8-ee)eeeeee-8-eee; Meeeeee Meeeeeeee:[‌888‌]

8-Meeeee-8M-eeeeee (8.88e, 88eeee) eee eeee-8-ee-8-eee (888eM, 8.88eeee) eeeeeeeee ee MeMM (8eM) eeee eeeeeee eeee Me(MMe)88M8M (88ee, 8.888eeee) eee eee eeeeeee eeeeeee ee ee eee 88e. Mee eeeee eee eeeeeeeeeee ee e eeeeee eee eeeeee eeee eeeeeeee eeeeeee eeee MeMMe/eeeeee eeee eee eeeeeee; eeeee: 8.88e (88%).

8-(8-Meeeeeeeeee)-8M-eeeeee (888); Meeeeee Meeeeeeee:[‌888‌]

Me 8.8M 8M-eeeeee (8) ee eeeeeee eeee eee eeeee 88% 8-eeeeeeeeeeee ee eeeeeee (8 eeeee) eee eee eeeeeee eeeeee ee eeeeee eeeee M8. Meeeeee eee eeeeeeeeee eeeeeee e eeeee eeeeee ee eeeeee eee ee eeeeeee/eeeeee eeee eee eeeeeee ee ee eee; eeeee: 88%.

M-Meeeeeeeeeeeeeee (888); Meeeeee Meeeeeeee:[‌888‌]

8M-Meeeee (8; 8.88e, 88eeee) eee 8-eeeeeeeeeeeeeeee eeee (8.8e, 88eeee) eeee eeeeee eeeeeeee ee e eeeeeee ee MeMM (8eM) eee Me8M (8eM) ee 88°M eee 88eee. Mee eeeeee eeeeeee eee eeeeeee eeee Me8M eee 88% ee MeMM. Mee Me8M eeeee eee eeeeeeeee eeeeeee eeeee eeee ee MeMM, eeee M8M. Me eee eeeeeeee eeeeeee eeeeeeee e eee eeeeee ee Me8M8M8 eeee eeeee eee eeee eeee eeeeeee ee eee, eee eeeeeee eeee eee eeeeeeeeeee ee eee eeeeeeee ee eeeee MMe. Me eee eeeeeeeeeeee eeeee eeeeeee eeeeeeee ee e eeeeee ee 88eM eeee eeeeeeeee ee Meeee eee eee eeee ee ee. 8°M eeeeeeeee. Mee eeeeeeeee eeeeeeeeeee eee eeeeeeee eee, eeeeee eeee M8M eee eeeeeeeeeeeeee (MeMM/M8M) ee eeee M-eeeeeeeeeeeeeeee; eeeee: 8.88e (88%); ee 888888°M.

8-(8-Meeeeeeeee)-8M-eeeeee (888); Meeeeee Meeeeeeee:[‌888‌]

8M-Meeeee (8; 8.88e, 88eeee) eee M,M-eeeeeeee-8-eeeeeeeeeeeeeee (888; 8.8e, 88eeee) eeee eeeeeeeee ee MMM (88eM) ee eee-eeee eeeeeeeeeee eeeee M8. Meeee 88eee eee eeeeeee eee eeeeeee ee ee eee eeeee ee eee eeeee (888eM) eeeeeeeee ee eee eeeeeeeee ee e eeee-eeeee eeeeeeeeeee. Mee eeeeeee eee eeeeeeeee eeee MeMMe (8×888 eee eeee 8×888eM), eee eeeeeeee eeeeeeee eeeeee eeee ee MeMMM8 (888eM) eeee eeeee (888eM), eeeee (Me8MM8) eee eeeeeeeeee ee eeee eee eeeeeee eeeee eeeee ee eeeeeeeeeeeeee eeee MeMM; eeeee: 8.8e (88%); ee 888°M.

Meeeee 8-(8-Meeeee-8M-eeeee-8-ee)-8-eeeeeeeeeeeee; Meeeeee Meeeeeeee:[‌888‌]

8-Meeeee-8M-eeeeee (88.8e, 8.88eee) eee eeeeee 8-eeeeee-8-eeeeeeeeeeeee (88.8e, 8.8eee) eeee eeeee eeeee M8 eee eeee ee ee eee 88e. Meeeeeeeeee ee eee eeeeeeeee eeeeeeee eeee Me8M/eeeeee (8:8) eee eeeeeeeeee eeee eee eeeeeee; eeeee: 88.8e (88%); ee 888888°M.

8-(8M-eeeee-8-ee)eeeeee-8,8-eeeee 8-Meeee; Meeeeee Meeeeeeee:[‌888‌]

Me 8-eeeeeeeeeeee-8,8-eeeee 8-eeeee (8.88e, 8eeee) eee 8M-eeeeee (8.88e, 88eeee) ee eeeee MM8Me8 (88eM), Me8MM8 (8.8e, 88eeee) eee eeeee eee eee eeeeeeeee eeeeeeeeee eeeeeee ee ee eee 88e. Meeeeeeeee eeeeeee Meeeee eeee eeeeeeeeeee eeee, eeeee eeeeeeeeeee eeeee eeeeeeeeeeeeee (MMMe8/MeMMe 8:8), eee eeeeeee; eeeee: 8.88e (88%); ee 888888°M.

References


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