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10.13.1.5.4.1 Method 1: Of C-Halogen Indoles

DOI: 10.1055/sos-SD-010-00559

Joule, J. A.Science of Synthesis, (200110591.

There are many examples of removal of halogen by catalytic hydrogenolysis.[‌1194‌,‌1195‌] Selective hydrogenolysis of the heterocyclic ring halogens in hexachloro-1-methyl-1H-indole gives 4,5,6,7-tetrachloro-1-methyl-1H-indole.[‌889‌] Chemical reductants, zinc/acetic acid or sodium amalgam are also employed.[‌344‌,‌1196‌] 4-Chloro groups are removed by irradiation in methanol.[‌1197‌]

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