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10.13.3.1.1.2.1.1 Method 1: From (o-Nitroaryl)acetic Acids and Esters

DOI: 10.1055/sos-SD-010-00559

Joule, J. A.Science of Synthesis, (200110607.

(o-Nitroaryl)acetic acids/esters can be prepared in a number of ways: displacement of halogen ortho to an aromatic nitro group with malonate (1149 1150) then hydrolysis and nitro group reduction produces 1,3-dihydro-2H-indol-2-ones 1151 with loss of carbon dioxide (Scheme 425).[‌209‌,‌1264‌,‌1265‌]

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