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Please login to access the full content or check if you have access via Method 1: Condensation of 1,4-Diketones with Indoles

DOI: 10.1055/sos-SD-010-00864

Gallagher, P. T.Science of Synthesis, (200110706.

The condensation of indoles (e.g., 47) with diketones (e.g., 48) is a much utilized synthesis of carbazoles.[‌68‌] The reaction is acid catalyzed and has been reported predominantly for electron-rich indoles substituted with methoxy or dimethyl substituents (Scheme 21).[‌68‌] Yields range from 36 to 45% and this is the preferred method of choice for the synthesis of 1,4-dimethyl-9H-carbazoles.[‌69‌,‌70‌]

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