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11.8.1.1.2.1.5.1 From 2-Oxoalkyl N,N-Disubstituted Dithiocarbamates

DOI: 10.1055/sos-SD-011-00303

Schukat, G.; Fanghänel, E.Science of Synthesis, (200211201.

The cyclization of the easily accessible 2-oxoalkyl N,N-disubstituted dithiocarbamates 35 with a strong acid (perchloric,[‌19‌,‌39‌,‌44‌,‌71‌‌75‌] sulfuric,[‌76‌‌83‌] or tetrafluoroboric acid/phosphorus pentasulfide[‌76‌,‌84‌,‌85‌]) is the best method for the preparation of N,N-disubstituted 2-amino-1,3-dithiolium salts 36 (Scheme 11). The cyclization with tetrafluoroboric acid can also be accomplished in the absence of phosphorus pentasulfide.[‌86‌]

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