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Please login to access the full content or check if you have access via11.9.4.3.1.2 Reduction of Nitroisoxazoles
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Wakefield, B. J., Science of Synthesis, (2002) 11, 278.
The most consistently useful reagents for reducing nitroisoxazoles 127 to isoxazolamines 128 are tin(II) chloride in hydrochloric acid and aluminum amalgam in moist solvent (Scheme 75), although successful reductions with other reducing agents have been reported.[1]
Meeeee 88 Meeeeeeee ee Meeeeeeeeeeeeee ee Meeeeeeeeeeeee[888,888,888–888]
M8 | M8 | Meeeeeee Meeee | Meeee (%) ee 888 | Mee |
---|---|---|---|---|
M | Me | Me/Me, M8M | 88 | [888] |
Me | Me | Me/Me, M8M | 88–88 | [888,888] |
Me | MM=MMMe | MeMe8 | 88 | [888] |
Me | MM8 | Me/Me, M8M | 88 | [888] |
Meeeeeeeeeee Meeeeeeee
8-Meeeeeeeeeeeee-8-eeeee (888, M8 = M; M8 = Me); Meeeeee Meeeeeeee:[888]
M eeee ee 8-eeeeee-8-eeeeeeeeeeeeee (888, M8 = M; M8 = Me; 88.88 e, 8.888 eee) ee MMM (888 eM) eee eeeee eeeeeeee ee e eeeeeeeeee ee Me eeeeeee [eeee Me eeee (8.88 e, 8.888 eee)] ee MMM (888 eM) eee M8M (88.8 eM, 8.888 eee), eee eeeeeeeeeee eeeee eeee ee eeeee 88°M. Meeee eee-eeeee, eee-eeeeee, eee eeeeeeee eeeeeeee ee eee eeeeeeeee eeee, eeeeeee Me eeee (8.88 e eeee eeeeeeee) eee M8M (88 eM eeee eeeeeeee) eeee eeeee. Meeee eeeeeeee eee eeeeeeee, eee eeeeeee eee eeeeeee ee ee eee 8 e. Mee eeeeeee eee eeeeeeee eee eee eeeeeeee eeeee eeee eeeeee eeee MMM eeeee ee MM-eeeeee eeeeeeee eeeee ee eeeeeeee ee eee eeeeeeee (MMM). Mee eeeeeeee eeeeeeeee eeee eeeeeeeeeeee eeeee eeeeeee eeeeeeee, eee eee eeeeeee eee eeeeeee eeee eee MeMM (888 eM) eee eeeeeeeeeeeeee. Mee eeeeeeee eee eee eeeeeee eeee Me8M eee eee eeee eee eeeee (MeMM8), eeeeeeee, eee eeeeeeeeeeee. Mee eeeeeee eee eeeeeeeee ee eMeMM (888 eM), 88 M MMe eee eeeee, eee eee eeeeeee eee eeee ee ee eeeeeeeee. Mee eeeee eeee eeeeeeeeeeee eee eeeeeeeee, eeeeee eeee eMeMM, eee eeeee, eeeeee eeeeee eeeee eeeeeeee; eeeee: 88.88 e (88%). Mee eeeeeeee eee eeeeeeeeeeee ee eeeee e eeeee, eeeee eee eeeeeeee ee eeeeeee, eeeeeeeee, eeeeee, eee eeeee, eeeeee eeeeeee eee-eeeee eeee eeeeeeee; eeeee: 8.88 e (88%); eeeeeeee eeeee: 88.88 e (88%); ee 888–888°M.
References
[1] | Meeeeeeee, M. M., Me Meeeee–Meee, (8888); Mee. M 8e, ee 88, 88. |
[224] | Meeeeeee, M.; Meeeeeee, M. M.; Meeeeee, M. M.; Meeeeeeee, M. M., M. Meee. Mee., Meeeee Meeee. 8, (8888), 888. |
[242] | Meeeee, M. M., M. Mee. Meee., (8888) 88, 8888. |
[277] | Meeeee, M. M.; Meeeeee, M., M. Meee. Mee., (8888) 888, 888. |
[278] | Meeeeeeeeeeee, M.; Mee, M. M. M. M. M.; Mee, M. M. M., Meeeee M. Meee. Meee., (8888) 88, 88; Meee. Meeee., (8888) 88, 888888. |
[279] | Meeeeeeee, M.; Mee, M. M.; Meeeeee, M., M. Meeeeeeeee. Meee., (8888) 88, 888. |
Meeeeee Meeeeeeeeee
- 8.Meeeee-Meee, (8888) M 8e, 888.