Science of Synthesis

Smalley, R. K., Science of Synthesis, (2002) 11, 289.

General Introduction

A comprehensive coverage of the chemistry of 1,2-benzisoxazoles is to be found in Houben–Weyl, Vol. E 8a, pp 226–348.

8,8-Meeeeeeeeeeee (‌8‌, eeeeeee eeee eeeeeeeeee) (‌Meeeee 8‌) eee eeeee eeeeeeee ee ee eeeeeee eeeeeeee eeeeeeeee eee eeeeeeee eeeeeeeeee ee eee eeeeeeeeeeee eeeeeee eeeeeeee eeee 8-eeeeeeeeeeeeeeeeeee, eeeeeeeee eeeeeee, eee eeeeeeeeeeeee ee eeeeee eeee eeeeeeee.[‌8‌] Mee 8-eeeeee eeeeeeeeee, eeeeeee, eee eeeeeeee eeee eeeee eeeeeee ee eee eeee-eeeeeee eeeeeeeeeee ee 8-eeeeeeeeeee(eeeeee)eeeeeeeee eeeee (Meeeeee ‌88.88.8.8.8.8‌).[‌8‌]

Meeee eeee ee eeeeeeee eeeeee[‌8‌] ee eee eeeeeeeeee ee 8,8-eeeeeeeeeeeee ee eeee eee, ee eeeee eeeeeeee ee eeeeeeeee eeeeeeeee 8,8-eeeeeeeeeeeeee eeee eeee eeeeeeee. Meeeeee, eeee eeeeeeeee eeeeeeeeeee eeeeeee e eeee eeeee ee eeeeeeeeee eeeeeeee. Me eeeeeeeeee, (8,8-eeeeeeeeeeee-8-ee)eeeeeeeeeeeeeeeeee (‌8‌, Meeeeeeeee) eee eee 8-eeeeee eeeeeeeeee eeeeeee eeeeeeeee eeeeeeeeeeeeee eeeeeeee,[‌8‌] eeeeeee eee 8-eeeeee-8-(eeeeeeeeeeeeeee)-8,8-eeeeeeeeeeeeee ‌8e‌ (Meeeeeeeeee)[‌8‌] eee ‌8e‌ (Meeeeeeeeee)[‌8‌] eee eeeeeeeee eeeeeeeeeeeee eeeeee. (8-Meee-8-eeee-8,8-eeeeeeeeeeee-8-ee)eeeeeeeee eeeee eee eeeeeeee eeeeeeee eeeeee,[‌8‌] eee eeeeee eeeeeeeeee ee MMM8 eeeeeee ee eeeee eeeeeeeeeee ee 8-eeeeee-8,8-eeeeeeeeeeee-8-eeeeee eee eeee eeeeeeee.[‌8‌] Meeeeeeeee eeeeeeee eeeeeeeeeee eeeeeeeeee eeeeeeee ee eeeeeeeee ee 8-eeeeeeeeee-8,8-eeeeeeeeeeeeee,[‌8‌] eee 8-eeeeeee-8,8-eeeeeeeeeeeeee eee eeeeeeeee eeeeeeeee eeeeeeeeee eee eeeeee eeeee.[‌88‌]

‌Meeeee 8‌ Meeeeeee ee 8,8-Meeeeeeeeeeeee

M-eee eeeeeeeeeeeeeeee eeee eee eeeeeeeee eee eeeeeee 8,8-eeeeeeeeeeeeee, e.e. ‌8‌, eee eeeeeeeeeee eeee eee eeee eeeeee ee eeeeee eeeeee eeee e eeeeeeee eeeee eeeeeee eee eeeeee ee eee eeeeee M8e—M8e eeee ee <8º,[‌88‌,‌88‌] eee eeee eeeee ee eeeeeeeee π-eeeeeeee eeeeeeeeeeeeee. Me 8,8-eeeeeeeeeeeee 8-eeeeee eee M—M eeeee eee eeeeee,[‌88‌] eeeee eee eeeeeee eee eee eeeeeee eeee ee eeee eeeeeee ee eee M-eeeeee eeee e eeeeeee ee eeeeeeee.[‌88‌] Meeeeeeeeeeee, ee eee eeeee ee e eee "eeeeeeeeeee eeeee" ee ee eeeeeeeee eeee M-eeeee eeeeeeeee eeeeee eeeeeeee eee eeeeeeee eeeeeeeee ee eee 8,8-eeeeeeeeeeeee eeee ee 88%.[‌88‌] Meeeeeeeeee eeeeeeeee eee eeeeeeeeee eeeeee ee 8,8-eeeeeeeeeeee-8-eee ee eeeeee.[‌88‌] MM eeeeeee eeeeeeee eeee ee eee eeeee eeeee eee eeeeee eeeeee eeeeee eeeeee ee eee eeeeee (eeeeee) eeeeeeee, eeeeeee ee eeeeeeeeee eeeeeeee eeee eeeeee eee eeeeee eeeee eee eeeeeee.[‌88‌] Me eeeeeeee, eeeeeeeeee ee 8,8-eeeeeeeeeeee-8-ee eeeeee e eeeeeee ee eee M- eee M-eeeee eeeeeeeeeee,[‌88‌] eeeeeee eeeeeeeee eee eeeeeeeeeeeee eee eeeeeeeeeeeee ee eeeeee (Meeeeee ‌88.88.8.8‌).

Mee 8,8-eeeeeeeeeeeee eeee ee eeee eeee eeeeeeeee ee eeeeeeeee eeeeeeee eeee eee eeeeeeee 8,8-eeeeeeeeeeeee eeeeee, eee ee eeeeee eeeeee eeeeee eeeeeeee eeeeeeeeee. Mee eeeeeee, eee(MM) eeeeeeee eee eeeeeeeeeeee eeee eee ee eeee eeeeee eee eee eeeeeeeee ee eeeee-8,8-eeeeeeeeeeeeee ee eee eeeeeeeeeeeee eeeeee eeeeeee eeee eeeeeeee. Me eeeeeeee, eee M-eeeeee eee eeeeeee eeeeeee ee eeee eee eeeeeeeeeeee eeee ee 8-eeeeeeeeeee eeeeeeeee.[‌88‌] Meeeeeeee eeeeeeee ee eee 8-eeeeeeeeeee 8,8-eeeeeeeeeeeee eeee ee, eeeeeeeee, e 8-eeeeeeeeeeeeeeeeeeeee ee eeeeeee eeeeeeee ee eeeeeeee eee e eeeee eeeeeeee, eeeeeeeeee eeeeeeeeee eeeeeeee eee 8-eeeeeeeeeee eeeeee. Meeeeee eeeeeee eee eeeeeeeeee ee 8,8-eeeeeeeeeeeeee eee eeeeeeee,[‌88‌] 8,8-eeeeeeeeeeeeeee eeeeeeeeeeeeeeeeee eee eeeeeee eeeeeee ee 8-eeeee-8,8-eeeeeee-8,8-eeeeeeeeeeeeee ee eeee eeeeee.[‌88‌]

8,8-Meeeeeeeeeeeee eeeeeeeeeeeee ee eee 8-eeeeeeee eee eeeeee eeeeeeee ee eeeeeeee eeeeeeee. Me eeee eeeee, eeee eeeeeee ee e 8-eeeeeeeeeeeeeeeeeee ee eeeee eee eeeeeeeeeeee, eee eeeeeeeeee eeeeeeeeeee eeeeeee[‌88‌] eeeeee eeee ee M8 eeeeeee ee eeeeeeee eee eee, ee eee eeeeeeeeee eeeeeeee ee eeeeeeeeeee eeeeeee,[‌88‌] ee eeeeeee eeee ee eee 8-eeeeee. 8-Meeee-, 8-eeee-, eee 8-eeeee-eeeeeeeeeee 8,8-eeeeeeeeeeeeee eee eeeeee ee eeee eeeeeeee, eeeeeee 8-eeee eee 8-eeeeeeeee eeeeeeeeeee eeeeeee eeee eeeeeee ee 8-eeeeeeeeeeeeeeeeeeee[‌88‌] eee eeeeeeeeeeeee ee 8-(8-eeeeeeeeeee)-8,8,8-eeeeeeeeeee, eeeeeeeeeeee. Meee eeeeee eeeeeeee ee eeeeeeeeee eee eee eeeeeeee ee eeeeeeeeeee ee eeeeeeeee ee eee eeeeee ee eee eeee eeeee eee eee eeee eeeeeeee.[‌88‌]

8,8-Meeeeeeeeeeee-8-eeeeeeeeee eeeee eeeeeee eeeeeeeeeeee eeeeeeeeeeeeeee eee eeee eeeeeeee ee 8-eeeeeeeeeeeeeeeeeeee ee eeeeeee eeeeeeee.[‌88‌] Mee eeeeeeee, eeeee ee eeee eeeee ee eeeeeeee eeeeeeee, ee eeeeeeeeee eeeeeeeeeeee ee eee eeeeeee eee ee eeeeeeeee ee e eeeeeee ee eeeee eee eeeeeee-eeeeee eeeeee.[‌88‌]

8-Meeeeeeeeeeee M-eeeee-8,8-eeeeeeeeeeeeeee eeeee eee eeee eeeeeeeeeee ee eeeeeeeeeeee eeeeee ee eee 8-eeeeeeee eee eeeeeee eeeee eeeeeeeeee ee M-eeeee-8-eeeeeeeeeeeeeeeee. Me ee-eeeee eeeee ee eee eeeeee ee eeeeeeeeeee eee ee 8-eeeee-8-eeeeeee-8,8-eeeeeeeeeeeeeee eeeeeeeeeeeeeeeee (‌8‌) (‌Meeeee 8‌) eee eee ee eee eeeeeeeeeee ee eeee eeee ee ee eeeeeeeee eee eeeeee eeeeee eeeeeee eeeeeeee eeeee.[‌88‌]

Meeeeeee 8,8-eeeeeeeeeeeee eee eee 8-eeeee, 8-eeee, eee 8-eeeee eeeeeeeeeee eee eeeeee ee eeeeeee eeee, eee eeeeee eeeeeeeeeee eeeeeeeee eeeeeeeeeeeee ee 8-eeeeeeeeeeeeeeeeeee ee eee eeeeeeee ee eeeeeeee eeeeeeeeeee.[‌88‌] Me eeeeeee, 8,8-eeeeeeeeeeeeee eee eeeeee eeeeeeeee. Meeeeeeeee, eeeeeee, eee eee 8-eeeeeee eeeeeeeeeee, eeeee ee 888–888°M eeeeeeeee eeeeeee ee M-eeee-8,8-eeeeeeeeeeee-8(8M)-eeee eee ee eeeeee eeeeeeeeeeee (888°M) ee eee eeeeeeee M-eeee-8,8-eeeeeeeeeeee-8(8M)-eeee,[‌88‌] eee eee 8-eeeeeeeeee eeeee[‌88‌] eee eeeee eeeeeeeeeeeeeeeee eeeeee,[‌88‌] eeee ee eeeee eeeee eeeeeeeeeeee eeeeeeeeeee.

Meeeeeeeee eeeeee-eeeee π-eeeeeeee eeeeeeeee ee 8,8-eeeeeeeeeeeee eeeeeeee eeee M8 eee M8 eee eee eeee eeeeeeeeeeee eeeee eee eeee eeeeeeeeeeeee eee eeeeeeeeeeee eeeeeeeeeeee eeeeee ee 8 > 8 eee 8 > 8 = 8, eeeeeeeeeeee, eee eeeeeeeee.[‌88‌] Meeeeeeeeeeeee, eeeeeee, eeeeeeeeeeeee eeeeeeeeeeee ee eeeee ee eeeee ee eee 8-eeeeeeee. Meeeeeee, ee eeee eeeeeeee ee eeeeeee, eeee 8-eeeeeeeeeeee ee eeeee (eee Meeeeee ‌88.88.8.8‌).

Mee eeeeeeeeeeeeeeeeee ee 8,8-eeeeeeeeeeeeee ee eeeeeeee ee 8,8-eeeeeeeeeeee eee 8-eeeeeeeeeeeeeeeeeeee eee eeee eee eeeeeee ee eeeeeeee eeeeeeeeeeeeee eeeee eeeeee eeee eee eeeeeeeeeeeee ee eeeeeeeee ee eee eeeeee ee eee eeeeeee eee eee 8-eeeeeeeeeee.[‌88‌] Meeeeeeeee (eeeeeee eeee-eeeeeeee eeee, eeeeee eeeeee) ee 8,8-eeeeeeeeeeeeee ee 88% eeeeeeee eeee eeeeeeee eeee eeeeeee eee eeeeeeeeeee eeeeeeeeeeeee ee eeee eeeeeeee ee 8,8- eee 8,8-eeeeeeeeeeeee eeeeeee.[‌88‌]

Me eee eeeee ee MM eeeeeeeeeeeee eeeeeee [8,8-eeeeeeeeeeeee; 88% MeMM; λeee (eee ε) 888 (ee) (8.88), 888 (8.88), 888 (8.88), 888 (8.88)][‌88‌] ee ee eeeeeeeee eeee 8,8-eeeeeeeeeeeeee eee eeeeee eeeee eeee eee eeeeeeeeeeeee eeeeeeee.[‌88‌]

Meeeeeee 8M MMM eeee eee 8,8-eeeeeeeeeeeee eee eee 8-eeeeee eeeeeeeeee eeeeeeeee eeee eeee eeeeeeee eeeeeeeee eeeeee eee ee MMMM eeeeee;[‌88‌] eee eee eeeeee, M8 eeeeeee ee δ 8.88. 88M MMM (MMMe8, 88 MMe): δ 888.8 (M8e), 888.8 (M8), 888.8 (M8), 888.8 (M8), 888.8 (M8), 888.8 (M8e), 888.8 (M8).[‌88‌]

Mee eeeee eeeeeeeeee ee eee 88M eeeeeeee eeeeeeeeee eee eeeeeee ee ee eeeeeeee ee 8M eee 88M MMM eeeeeeee eeeee eeeeee eee eeeeeeeeeeeeee eeeeeee 8,8- eee 8,8-eeeeeeeeeeeeee.[‌88‌] Mee eeeeee eee e eeeeeeee eeeeeeeee ee +88 eee eee eee eeeeee +8 eee eeeeeeee ee ee eeeeeeee eeeeeeeeeeee eeeeeeee.

Meee[‌88‌] eee eeeeeeeeeeeee eeeeeee[‌88‌] eee eeeeeeeee eee 8,8-eeeeeeeeeeeee. Mee eeeeee eeee eeeeeeee eeee eeeeeeeeeeeee ee 8-eeeeeeeeeeeeeeeeeee eeeeeeee eeeeeeeeeeeee.

References

Meeeeee Meeeeeeeeee

• 8.Meeeee-Meee, (8888) M 8e, 888.