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Please login to access the full content or check if you have access via11.12.1.1.4.5 Method 5: From α-(Hydroxyamino)phenylacetic Acid and Aldehydes
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Boyd, G. V., Science of Synthesis, (2002) 11, 408.
α-(Hydroxyamino)phenylacetic acid (101) condenses with aldehydes to give 2-substituted oxazol-5(4H)-ones 102 (Scheme 42).[111] The reaction with ketones yields 2,2-disubstituted 4-phenyloxazol-5(2H)-ones, a type of compound that is outside the scope of this section.
Meeeee 88 8-Meeeeeeeeee Meeeee-8(8M)-eeee eeee α-(Meeeeeeeeeee)eeeeeeeeeeee Meee eee Meeeeeeee[888]
Meeeeeeeeeee Meeeeeeee
8-Meeeeeeee-8-eeeeeeeeeeee-8(8M)-eee (888, M8 = eMe):[888]
M eeee ee α-(eeeeeeeeeeee)eeeeeeeeeeee eeee (888; 8.8 e, 8.8 eeee) eee Me8M (8.88 eM, 8.8 eeee) ee eMeMMM (88 eM, 888 eeee) eee eeeeeee ee 88°M eee 8 e, eee eeee eeeeeeeeeeee eeeee eeeeeee eeeeeeee. Meeeeeeeeeeeee ee eee eeeeeee eeee eee eeeeeee; eeeee: 8.88 e (88%); ee 888°M/8.88 Meee.
Mee 8-eeeee eeeeeeee 888 (M8 = Me) eee eeeeeeee eeee MeMMM (8.88 e, 88.88 eeee) eee eeee, ee MMM ee ee eee 88 e; eeeee: 88%.
References
| [111] | Meeee, M.; Meeeeee, M.; Meee, M., Meeeeeeee, (8888), 88. |
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