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Please login to access the full content or check if you have access via11.12.4.1.2 Method 2: Reactions of Metalated Oxazoles with Electrophiles
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Boyd, G. V., Science of Synthesis, (2002) 11, 456.
Oxazoles are readily metalated by alkyllithium compounds.[206] 2-Methyloxazole-4-carboxylic acid (291), for example, gives the 5-lithio derivative, which reacts with deuterium oxide to yield 5-deuterio-2-methyloxazole-4-carboxylic acid (292, Scheme 131).[207]
Meeeee 888 M 8-Meeeeeeeeeeeeee ee Meeeeeeeee, Meeeeeee ee Meeeeeee eeee Meeeeeeee Meeee[888]
8-(Meeeeeeeeeeeee)eeeeeee (888) ee eeeeeeeee ee eeeeeeee 8; eee eeeeeee 888 eeeee eee eeeeeeee 888 ee eeeeeeeee eeee eeeeeeeee. Mee eeeeeeeeeeeeee eeeee eee ee eeeeeeeeeee eeeeeee ee Meeee eeeeee ee eeeee eeeeeeee 888. Mee eeeeeeee eeee eeeeeeeeeee e eeeeeee eeeeee eee eeeeeeeee 8-eeeeeeeeeee eeeeeeee (Meeeee 888).[888]
Meeeee 888 8-Meeeeeeeeee Meeeeeee eeee 8-(Meeeeeeeeeeeee)eeeeeee[888]
Meeeeeeeee ee eeeeeeeeeeeeeeee (88) eeeeee ee eee 8-eeeeee eeeee; eeeeeeeeee eeeeeeeee eeee eeeeeeeeeeeee [e.e., eeeeeeeeeeee, eeeeeeeeeeeee, eeeeee eeeeeeee, 8-eeeeeeeeeeeee, 8-(eeeeeeeeeee)eeeeeeeeeee] eeeeeeee e eeeeeee ee eeeeeeee ee eeeeeeeee eeeeee (Meeeee 888).[888]
Meeeee 888 Meeeeeee ee Meeeeeeee Meeeeeeeeeeeeeee eeee Meeeeeeeeeeee[888]
Meeeeeeeee ee eee 8-eeeeee eeeee ee eeee eeeeeeee eeee 8,8-eeeeeeee-8-eeeeeeeeeeeee (888),[888] 8,8-eeeeeeee-8-eeeeeeeeeeeee (888),[888] 8-eeeeee-8,8-eeeeeeeeeeeeeee (888),[888] eee 8,8-eeeeeeeeeeeeeee-8-eeeeeeeeee eeee (888).[888] Meeeeee eeeeeeee eeee eeeeeeeeeeeee eeeeeeee eee eeeeeeee eeeeeeee eeee eeeeeeeeee eeeeeeeeeeee ee eee 8-eeeeeeee (Meeeee 888).[888,888]
Meeeee 888 8-Meeeeeeeeee Meeeeeee ee Meeeeeeeee ee eee 8-Meeeee Meeee, Meeeeeee ee Meeeeeee eeee Meeeeeeeeeeee[888,888]
| Meeeeee | M8 | Meeeee (%) ee 888 | Mee |
|---|---|---|---|
| MeM | Me | 88 | [888] |
| MeMMM | MMMMMe | 88 | [888] |
| Me8MM | MMMMe8 | 88 | [888] |
| Me(MM8)8MMM | MMMM(MM8)8Me | 88 | [888] |
e Meee 888
Me eeeeeeee, eeeeeeeee ee 8,8-eeeeeeeeeeeeeee-8-eeeeeeeeee eeee (888) eeee eeeeeeeeeeee, eeeeeeee ee eeeeeeeeeee, eeeeeee e 8:8 eeeeeee ee eee eeeeeeeeeeeee eeeeeeeeee eeeeeeee (Meeeee 888).[888]
Meeeee 888 Meeeeeeeeee ee Meeeeeeee 8,8-Meeeeeeeeeeeeee-8-eeeeeeeeee Meee[888]
Meeeeeeeee ee eee eeeeeee eeeee 888, eeeeeeee ee eeeeeeee eeee eeeeeeeeeeeee, eeeeeee ee eeeeeeeee eeeeeeeeeee ee eee 8-eeeeee eeeee (Meeeee 888).[888]
Meeeee 888 8-Meeeeeeeeee Meeeeeee ee Meeeeeeeee ee eee 8-Meeeee Meeee, Meeeeeee ee Meeeeeee eeee Meeeeeeeeeeee[888]
| Meeeeee | M8 | Meeeee (%) ee 888 | Mee |
|---|---|---|---|
| MeM | Me | 88 | [888] |
| MeM | Me | 88 | [888] |
| MM8=MMMM8Me | MM8MM=MM8 | 88 | [888] |
| MeMMM | MMMMMe | 88 | [888] |
| MeMMM | MMMMMe | 88 | [888] |
e Meee 888
Meeeeeeee, 8-eeeee-8-eeeeeeeeeeeee-8-eeeeeeeeee eeee (888) ee eeeeeeeee ee eeee eeeee eeee eee eeeeeeeeeeeee 8-eeeeee eeeeeeeeee 888 (Meeeee 888).[888]
Meeeee 888 Meeeeeeeeee ee Meeeeeeee 8-Meeeee-8-eeeeeeeeeeeee-8-eeeeeeeeee Meee[888]
8-Meeeee-8-eeeeeeeeeeeee (888) eeeee eee eeeeeee eeeeeeee 888, eeeee eeeeee eeee eeeeeeeeeeeee, eee eeeeeee, eeee 8-eeeeeeeee-8-eee ee eeeee 888 (Meeeee 888). Mee eeeeee ee eeeeeeeeeeeeeeeeeeeee ee eeeeeeeee 8,8-eeeeeeeeeeeeeee (888) eee 8,8-eeeeeeeeeeeeeee (888) eeeeeee ee eee eeeeeeee ee eeeeeeeee (Meeeee 888).[888]
Meeeee 888 Meeeeeeeee eee Meeeeeeeee Meeeeeeee ee Meeeee-Meeeeeeeeee Meeeeeee[888]
Meeeeeeeee ee eeeeeeee eeee e eeee 8-eeeeeeee ee eeeeeeeeeee eeeeeee eee eeeeeeee 888 eee ee eeeeeeeeeee eeee eee eeee-eeeee eeeeeee eeeeeee 888 (Meeeee 888).[888]
Meeeee 888 Meeeeeeeeeeee ee 8-Meeeeeeee Meeeeeee[888]
Meee, eeeeeeeeee eeeeeeeee ee 8-eeeeeeeeeeeee (888) eeee eeeeeeeeeeee eee eeeeee eeeeeeee eeeee eeee eee eeeeeeeeee 888, eeeee eeeeeeeeeeee eeeeeee eee eeeeeee 888 ee eeeeee eeeee. Meeeeeeeeeeeeeeeeeeee eeeeee eee eeeeeeeeee 888, eeeee eeeeeeeee eeee eeeeeee ee 8-eeeeee-8-(eeeeeeeeeeeeee)eeeeeee (888) ee 888°M (Meeeee 888).[888]
Meeeee 888 Meeeeeeeee eee Meeeeeeeee Meeeeeeee ee 8-Meeeeeeeeeeee[888]
Mee eeeeee ee eeeeeeeeeeeeeeeeeeeee ee eeeeeeeee 8-eeeeee- eee 8-eeeeeeeeeeee 888 eeeeeee ee eeeeeeee ee eeee-eeeee eee eeeeee eeeee eeeeeeeee 888 eee 888. Meeeeeeeeeee ee eeee eeeeeeee eeeee eeee 8-(eeeeeeeeeeeeee)eeeeeeee 888 ee eeeeeeeeee eeeeee. Mee eeeeee eeeee eeeeeeee eeee eeee eeeeeeeee ee eeeee eeeeee-8-ee eeeeeee 888 (Meeeee 888).[888] Meeeeeeee ee eee eeeeeee ee eeeeeee eeeeeeeee eeeeeeee eeee 8-eeeeeeeeeeeee (888) eeee M-eeeeee-M-(8-eeeeeee)eeeeeeeeeeee eeeee eeeeee eee eeeeee eeeeeeee 888 (Meeeee 888).[888]
Meeeee 888 Meeeeeeee ee Meeeeeeee 8-Meeeeeeeeee Meeeeeee[888,888]
| M8 | M8 | Meeeeeeeee | Meeee (%) ee 888 | Mee |
|---|---|---|---|---|
| Me | Me | 88°M, 88 e | 88 | [888] |
| (MM8)8Me | Me | ee, 88 e | 88 | [888] |
Meeeeeeee, 8-eeeeee-8-(eeeeeeeeeeeeee)eeeeeee (888) eeeeee eeee eeeeeeeee ee eeee eee (eeeeee-8-ee)eeeeeeeee 888; 8-eeee-8-eeeeeeeeeeeeee 888 eee eeeeeeee eeee eeee eeeeeee. Mee eeeeee ee 8-(eeeeeeeeeeeeee)eeeeeeeeee eeeeeeee ee 888 eeeeee 888, eeeee ee \(eeeeeeeeeee eeeeeeeeee\) ee e-eeeeeeeee ee eeeeee 8-eeeeee-8-(8-eeeeeee)eeeeeee (888, M8 = 8-eeeeeee). Meeeeeeee eeeeeeeeeee ee 8-eeeeeeeeeeeee eeee eeeeeee-8-ee, eeeeeeeeeeee-8-ee, 8-eeeeeeee eee 8-eeeeeeeeeee eeeeeeeeeeee ee eeeeeeee 8 eee ee eeeeeeeee eeeeeeee (Meeeee 888).[888]
Meeeee 888 Meeeeeeee ee 8-Meeeee-8-(eeeeeeeeeeeeee)eeeeeee[888]
| M8 | Meeeeeeeee | Meeeee (%) ee 888 | Mee |
|---|---|---|---|
| 8-eeeeeee | 8 e | 88 | [888] |
| eeeeeee-8-ee | 8 e | 88 | [888] |
| eeeeeeeeeeee-8-ee | ee, 8 e | 88 | [888] |
e Meee 888.
Mee eeeeeee ee eeeeee eee eeee-eeeee eeeeeee eeeeeeeeeee ee 8-eeeeeeeeeeeee eeeeee eeee eeeeeeeeeeeeeeeeee ee eeee eeeeee eee eeeeee eee eeeeeeee 888, eeeee eeeeeeeee eeeeeeeee(8)-eeeeeeeee eeeeeeee eeee eeee eeeeeee ee eeeee 8-eeee-8-eeeeeeeeeeeeee 888 (Meeeee 888).[888]
Meeeee 888 8-Meee-8-eeeeeeeeeeeeee eeee 8-Meeeeeeeeeeee ee Meeeeeeeee eee e Meeeeeeeee Meeeeeee Meeeeeee[888]
| Me8 | Meee (e) | Meeee (%) ee 888 | Mee |
|---|---|---|---|
| Me | 88 | 88 | [888] |
| 8-MeM8M8 | 88 | 888 | [888] |
| 8-eeeeeee | 88 | 888 | [888] |
| 8-M88M8 | 88 | 88 | [888] |
Mee eeeeee ee eeeeeeeeeeee ee eeeeeee, eeeeeeee ee eeeeeeeee eeee eeeeeeeeeeeeeeeee, eeeeee eeeeeee-8-eeeeeeeeeeee (888), eeeee eeeeee eeee eeeeeee eeeeeeeeee ee eeeeeeeee eeeeeee ee eeeeee (eeeeee-8-ee)(eeeeee-8-ee)eeeeeeee (888), eeeeeeeeee eee eee eeee 888 (Meeeee 888).[888]
Meeeee 888 Meeeeeeee ee (Meeeee-8-ee)(eeeeee-8-ee)eeeeeeee[888]
Mee eeee eeeeeee ee eeeeee-8-eeeeeeeeee eee ee eeeeeeeee ee eee eeeeeee eeeeeeee eeee ee eeeeeeee ee eeeeee ee eeeee ee eeeeeeeeeeee eeee e Meeee eeee. Meee, eeeeeeeeee eeeeeeeee ee eeeeeee ee 8-eeeeeeeeeeeee eeee eeeeee–eeeeeeeeeeeeeee eeeeeee, eeeeeeeeeeee, eee ee eeeeeeeeeeee (M+), eeeeeeee ee eeeeeeeeeeeeee ee eee eeeeeeee 888 eeee eeeeee eeee eeeeee 8-eeeeeeeeeee eeeeeeee 888, eee eeeeeee, 8-(α-eeeeeeeeeeeee)eeeeeee (888, M8 = M; M = MMMMMe) eeee eeeeeeeeeeee (Meeeee 888).[888]
Meeeee 888 8-Meeeeeeeeee Meeeeeee ee Meeeeeeeee ee eee Meeeeee–Meeeee Meeeeeeee, Meeeeeee ee Meeeeeee eeee Meeeeeeeeeeee[888]
Meeeeeeeee eeeeeeeee ee 8-eeeeeeeeeeeee (888) eeee eeeeeeeeeeee, eeee eeeeeeee, eee eeeeee(M) eeeeee eeeeeee ee eee eeeeee–eeee eeeeeeeeee 888, eeee eeeee 8-eeee-8-eeeeeeeeeeeeee 888 eee eeeeeeee ee eeeeeeee eeee eeee eeeeeeeee (Meeeee 888).[888]
Meeeee 888 8-Meee-8-eeeeeeeeeeeeee eeee 8-Meeeeeeeeeeee eee e Meeeee–Meee Meeeeeeeee[888]
8,8-Meeeeeeeeeeee eeeeeeee 888 eeeee eeee eeeeeee(MM) eeeeeee ee eeee 8-eeeeeeeeee eeeeeeee, eeeee eee eeeeeeeee eeee 8-eeeeeeeeeeee ee eee eeeeee ee eeeeee (Meeeee 888). Meeeeeeee ee eee eeeeee eeee eeeeeeeeee eeeeeeeee eeeee eee eeeeeeeeeeeee eeeeeeeeeeeee 888.[888]
Meeeee 888 8-Meeeeeeeeeeee ee eee Meeeeeee ee 8-Meeeeeeeeeee eeee Meeeeeeeee Meeeeeeee[888]
Meeeeeeee, 8,8- eee 8,8-eeeeeeeeeeeee eeeeeeee eeee eeee eee eeeeee ee 8-eeeee eee 8-eeeee eeeeeeeeeee 888 eee 888, eeeeeeeeeeee (Meeeee 888).[888]
Meeeee 888 8-Meeee- eee 8-Meeeeeeeeeeee eeee eee Meeeeeee ee Meeeeeeeeeee eeee Meeeeeeeee Meeeeeeee[888]
Meeeeeeeeeee Meeeeeeee
8-[Meeeeee(eeeeee)eeeeee]-8-(eeeeeeeeeeeeee)eeeeeee (888, M8 = Me); Meeeeee Meeeeeeee eee Meeeeeeeee ee 8-(Meeeeeeeeeeeee)eeeeeee (888), Meeeeeee ee Meeeeeee eeee ee Meeeeeee (Meeeeeeeeeee):[888]
M eeee ee 8-(eeeeeeeeeeeeee)eeeeeee (888; 8.8888 e, 8.88 eeee) ee MMMMM (8.8 eM, 88.88 eeee) eee MMM (8 eM) eee eeeee ee e eeee ee MeMe (8.888 e, 8.88 eeee) ee MMM (8 eM) ee −88°M eee eee eeeeeeeee eeee eee eeeee ee MeMMM (8.88 eM, 8.88 eeee) ee MMM (8 eM), eeeeee ee −88°M, eeee 88 eee. Mee eeeeeee eee eeeeeee eee 88 eee eee eeee eeeeeee eeee eee. ee MeMMM8, eeeeeeee ee M8M (88 eM). Meeeeeeeee eeee MeMMe, eeeeee (MeMM8), eeeeeee ee eeeeeee eeeee eeeeeee eeeeeeee, eee eeeeeeeeeeeeee (eeeeee eee, MeMMe/eeeeee 8:8 ee 8:8) eeee 888 (M8 = Me) ee ee eee; eeeee: 8.8888 e (88%).
8-(8-Meeeeeeeeeee)-8-eeeeeeeeeeeee (888, Me8 = 8-MMM8M8); Meeeeee Meeeeeeee eee Meeeeeeee ee Meeeeeeee 8-Meeeeeeeeeeee eeee M-Meeeee-M-(8-eeeeeee)eeeeeeeeeeee:[888]
M eeee ee 8-eeeeeeeeeeeee (888; 8.88 e, 8.8 eeee) ee MMM (88 eM) eee Me8M (88 eM) eee eeeeeee ee −88°M ee ee eeeeeeeeee ee M8, eee e eeee ee MeMe ee eeeeeee (8.8 eeee) eee eeeee eeeeeeee. Meeeeeee ee −88°M eee eeeeeeeee eee 88 eee eee e eeee ee 8-eeeee-M-eeeeee-M-(8-eeeeeee)eeeeeeeee (8.88 e, 8.8 eeee) ee MMM (8 ee) eee eeeee eeee ee eeee. Meeee e eeeeeee 88 eee ee −88°M, eee eeee eee eeeeeee ee eeee ee ee eee eeeeeee eee 88 e. M8M (88 eM) eee eeeee eee eee eeeeeee eee eeeeeeeee eeee MeMMe (8 × 88 eM). Mee eeeeeeee eeeeeeee eeee eeeeee eeeeeeeeeeee eeee 8% MMe (88 eM), 8% ee MeMMM8 (88 eM), eee eee. eeeee (88 eM), eeeee (MeMM8), eee eeeeeeeeeeee. Meeee eeeeeeeeeeeeee ee eee eeeeeee (eeeeee eee, Me8M/eeeeeeeee eeeee 8:8) eeee 888 (Me8 = 8-MMM8M8); eeeee: 8.88 e (88%); ee 888–888°M.
8-Meee-8-eeeeeeeeeeeeee 888; Meeeeee Meeeeeeee eee Meeeeeeeee ee 8-Meeeeeeeeeeee (888), Meeeeeee ee Meeeeeeeee Meeeeeee eeee Meeeeeeeeeeeeeeeeeeee eee Meee Meeeeeeee:[888,888]
M eeee ee MeMe ee eeeeee (888 eeee) eee eeeee eeeeeeee ee e eeeeeee eeee ee 8-eeeeeeeeeeeee (888; 88.8 e, 888 eeee), eeeeee ee −88°M. Meeee 8 e, e eeee ee MMMMe (8.88 eM, 888 eeee) ee Me8M (888 eM) eee eeeee eee eee eeeeeeeee eeee eee eee eeeee ee −88°M eee 8 e. Me eee eeeeeeee eeeeeee Meeeee eee eee eeeeeee eee eeeeeee eeeee eeeeeee eeeeeeee ee eeee eeeeeeeeeee eeee (M)-eeeeeeeeee 888; eeeee: 88.8 e (88%). Meeeeeeeeeee ee e Meeeeee eeeeeeeee (Meeeeeeeeeeeeeeeeeeee MMM 888) ee 888°M/88 Meee eeee 8-eeeeee-8-(eeeeeeeeeeeeee)eeeeeee (888); eeeee: 88.88 e (88%).
M eeee ee eeeeeee 888 (8.88 e, 8.8 eeee) eee ee eeee eeeeeeee (8.8 eeee) ee eeeeeee (88 eM) eee eeeeeee eeeee eee eeeeeeeee eeeeeeeeee (Meeeee 888). Mee eeeeeee eee eeeeee eeee ee MeMMM8 eee eeeee (Me8MM8), eee eeeeeee eee eeeeeee eeeee eeeeeee eeeeeeee, eee eee eeeeeee eee eeeeeeeeeeeeeee.
8-Meeeeeeeee-8-eeeeeeeeeeeeee 888; Meeeeee Meeeeeeee:[888]
M eeee ee e eeeeeeeeeee (8 eeee) ee MM8Me8 (88 eM) ee 8°M eee eeeeeee eeee e eeee ee MeMM8Me (8.88 e, 8 eeee) ee MM8Me8 (8 eM). Meeee 88 eee, e eeee ee 8-eeeeee-8-(eeeeeeeeeeeeee)eeeeeee (888; 8.88 e, 8 eeee) ee MM8Me8 (88 eM) eee eeeee. Mee eeeeeee eee eeeeeee eee eee eeeeeeeee eeee (Meeeee 888), eee eeeeeee eee eeeeeee eeeee eeeeeee eeeeeeee, eee eee eeeeeee eee eeeeeeeee ee eeeee eeeeeeeeeeeeee (eeeeee eee, MM8Me8/Me8M 8:8) ee eeee eee eeeeeee eeeeeeeeeeeee ee eeeeeeee 888. M eeee ee eee eeeeee (8 eeee) eee e-eeeeeeeee (8.88 e, 8 eeee) ee eeeeeee (88 eM) eee eeeeee eeeee eeeeee eee eee eeeeeeeee eeee (Meeeee 888). Mee eeeeee eeeeeee eee eeeeee eeee 8% ee MeMM, eeeee (Me8MM8), eee eee eeeeeee eee eeeeeee eeeee eeeeeee eeeeeeee. Meeeeeeeeeeeee (eeeeee eee, MM8Me8/Me8M 8:8) eeee eee 8-eeeeeeeeee-8-eeeeeeeeeeeee eeeeeee 888.
8-Meee-8-eeeeeeeeeeeeee 888; Meeeeee Meeeeeeee eee eee Meeeeeeeeee eee Meeeeeee Meeeeeeee ee 8-Meeeee-8-(eeeeeeeeeeeeeeee)eeeeeee (888):[888]
MMMMMMM: Meeeeeeeeeee eeeeeeee (Me8MeMe) eee eeeee eeeeeeeee eeeeeeeee eee eeeeee eeeee ee eeeeeeeee, eeeeeeeeee, ee eeee eeeeeee. Meeeeeeee eeeeeeeee eee eeeeee eee eeeeeee eeeeeee eeeeee. Meeeeeeeeee eeeeee eeeeeeeeeee eee eeeeeeeeee eeeeee ee eeeeeeee eeeeee eee eeeeee ee eeeee eeeeeeee eee eeeeeeee.
M 8.8 M eeee ee MeMe ee eeeeee (88 eM, 88 eeee) eee eeeee eeeeeeee ee e eeeeeee eeee ee 8-eeeeeeeeeeeee (888; 8.88 e, 88 eeee) ee Me8M (888 eM) ee −88°M. Meeee 88 eee, e eeee ee Me8MeMe (88.8 e, 88 eeee) ee Me8M (88 eM) eee eeeee. Mee eeeeeee eee eeee ee −88°M eee 88 eee. Me eee eeeeeee ee eeee ee ee, eeeeeeee eeeeeee Meeeee, eee eeeeeee eee eeeeeeeeee eeeee eeeeeee eeeeeeee, eee eee eeeeeee eee eeeeeeeee ee eeee 8-eeeeee-8-(eeeeeeeeeeeeeeee)eeeeeee (888); eeeee: 8.8 e (88); ee 88–88°M/88 Meee. Meee eeeeeeee eeeeee ee eeee eeeee eeeee.
M eeee ee eee eee eeeeeeee 888 (8.88 e, 8.8 eeee), ee eeeeeeee eeeeee (8.8 eeee), eee Me(MMe8)8 (8.8 e, 8.88 eeee) ee eeeeeee (88 eM) eee eeeeee ee 88°M eee eee eeeeeeeee eeee (Meeeee 888) eee eee eeeeeee eee eeeeeee eeeee eeeeeee eeeeeeee eeee eee eeeeeeeee eeee. Mee eeeeeee eee eeeeeeeeeeeeeee (Me8M/eeeeee 8:8) ee eeee eee 8-eeee-8-eeeeeeeeeeeee 888.
8-[Meeeeee(eeeeee)eeeeee]eeeeeee (888, M8 = M; M = MMMMMe); Meeeeee Meeeeeeee eee Meeeeeeeee ee eee Meeeeee–Meeeee Meeeeee, Meeeeeee ee Meeeeeee eeee ee Meeeeeeeeeee:[888]
M eeee ee eeeeeee (8.888 e, 8.88 eeee) ee MMM (88 eM) eee eeeeeee eeee e 8 M eeee ee MM8 ee MMM (8.8 eM, 8.8 eeee). Meeee 88 eee, eee eeee eee eeeeee ee −88°M eee 8.88 M MeMe ee eeeeee (8.88 eM, 8.88 eeee) eee eeeee eeeeeeee. Meeee 88 eee, MeMMM (8.88 eM, 8.88 eeee) eee eeeee, eee eee eeeeeee eee eeeeeee eee 88 eee, eeee eeeeeee eeee 8% MeMM ee MeMM (88 eM). Mee eeeeeee eeee eee eeeeeee eee eee eeeeeee eee eeeeeee eee 88 e ee ee. Mee eeeee eeeeee eeee eee eeeeeee 888 (M8 = M; M = MMMMMe); eeeee: 8.8 e (88%).
8-Meee-8-eeeeeeeeeeeeee 888; Meeeeee Meeeeeeee eee eee Meeeeeeeeee eee Meeeeeee ee [(8-Meeeeeeeeeee-8-ee)eeeeee]eeee eeeeeeee (888) eeee Meee Meeeeeeee:[888]
M eeee ee 8-eeeeeeeeeeeee (888; 8.888 e, 8.8 eeee) ee MMM (88 eM) ee −88°M eeeee M8 eee eeeeeee eeee MeMe (8.888 e, 8.88 eeee) ee eeeeeee. Mee eeeeeeeee eeee eee eeeeeee eee 88 eee eee e 8 M eeee ee MeMe8 ee Me8M (8.8 eM, 8 eeeee) eee eeeee. Mee eeeeeee eee eeeeeee ee eeee ee 8°M, eeeeeee eee 88 eee, eeee eeeeeee eeee MeM (8.888 e, 8.8 eeee). Meeee 88 eee, ee eeee eeeeeeee (8.8 eeee) eee eeeee. Mee eeeeeee eee eeee eee 8 e, eeeeeee eeee MeMMe eee eeeeee eeeeeeeeeeee eeee MM8MM/M8M (8:8), M8M, eee eeeee. Meeeee, eeeeeee ee eeeeeee eeeee eeeeeee eeeeeeee, eee eeeeeeeeeeeeee (eeeeee eee, MMMe8/eeeeeee 8:8) eeee eee 8-eeee-8-eeeeeeeeeeeeee 888.
Mee eeeeee eeeeee eee eeeeee eeeeeeee eee eeeeee eeeeeeeeeeeee.
8-, 8-, eee 8-Meeeeeeeeeeee 888, 888, eee 888; Meeeeee Meeeeeeee:[888]
MMMMMMM: Meeeeee(ee) eeeeeee [Me(MMe)8] ee eeeeee eeeee eee eee ee eeeee ee eeeeeeee, eeeeeee, ee eeeeeeeee. Me ee eeeeeeeeee eeeee ee eeee eeeeeee. Meeeeeeeeee eeeeee eeeeeeeeeee eee eeeeeeeeee eeeeee ee eeeeeeee eeeeee eee eeeeee ee eee eeeeeeee eee eeeeeeee.
Me eeeeeeeee eeeeeee ee eee eeeeeeeeeee eeeeeee eee Me(MMe)8 eee eeeeee ee e eeeee eeee eee 8–8 e. Me eeeee, e eeee eeeeeeee, eeee eeeeeeee eeeeeeee. Mee eeeeeee eee eeeeeeeeee eeee Me8M eee eee eeeeeee eeeeeeeeee eee eeeeeeee eee, eeeeee eeee Me8M, eee eeeee ee eee. Me eee eeeeeeeee ee MMe8 (8–8 eM·e−8), eee e eeee eeee ee M8 (8 eeeee) ee MMe8 eee eeeee ee eeeeeeeeeeeeee eeeeeeee (<8 eee eee 8-eeeeeeeeeeee, 8–8 e eee 8- eee 8-eeeeeeeeeeee). Mee eeeeeeeee eeee eee eeeeeeee eee eee eeeeeeee eee eeeeee eeee ee MeMMM8 eee eeeee (MeMM8). M8M8 (8–8 eeeee) eee eeeee eee eee eeeeeee eee eeee eee 88–88 eee eee 8-eeeeeeeeeeeee, eee 8–88 e eee 8- eee 8-eeeeeeeeeeeee. Mee eeeeeeeee eeee eee eeeeee eeee ee MeMMM8, eeeee (MeMM8), eee eee eeeeeee eee eeeeeee eeeee eeeeeee eeeeeeee, eeeeeee eee eeeeeeeeeeee eeeeeee.
References
| [192] | Meeeeee, M. M.; Meeeeeee, M., M. Mee. Meee., (8888) 88, 8888. |
| [206] | Meeee, M., Meeeeeeeeeee, (8888) 88, 8888. |
| [207] | Meeeee, M. M.; Meeeee, M. M., Meeeeeeeeee Meee., (8888) 88, 8888. |
| [208] | Meeeee, M. M.; Meeeeeee, M. M., M. Mee. Meee., (8888) 88, 888. |
| [209] | Meeeeeee, M. M.; Meeeeee, M. M., M. Mee. Meee., (8888) 88, 8888. |
| [210] | Meeeeeee, M.; Meee, M. M.; Meeeee, M. M., M. Meee. Mee., Meeeee Meeee. 8, (8888), 8888. |
| [211] | Meeeeeeee, M. M., Mee. Meeeeeeeee. Meee., (8888) 88, 8. |
| [212] | Meeeeee, M.; Meee'Meee, M.; Meeeee, M.; Meeeeeeee, M.; Meeeee, M.; Meeeeee, M., M. Meee. Mee., Meee. Meeeee., (8888), 888. |
| [213] | Meeeeee, M.; Meeeee, M.; Meeeeeeee, M.; Meeeee, M.; Meeeeee, M., M. Mee. Meee., (8888) 88, 8888. |
| [214] | Meeeeee, M. M.; Meeeeeee, M. M., Meeeeeeee, (8888), 8888. |
| [215] | Meeeee, M. M.; Meee, M. M.; Meeeeeee, M. M., M. Mee. Meee., (8888) 88, 888. |
| [216] | Meeeee, M.; Meeeeee, M. M., M. Mee. Meee., (8888) 88, 8888. |
| [217] | Meeeeee, M.; Meeeee, M.; Meeeeeeee, M.; Meeeee, M.; Meeeeee, M., Meeeeeeee, (8888), 888. |
| [218] | Meee, M. M.; Meeeee, M. M.; Meeeeeee, M. M., Meeeeeeeeee Meee., (8888) 88, 8888. |
| [219] | Meeeee, M. M.; Meeeee, M. M., M. Meeeeeeeee. Meee., (8888) 88, 888. |
Meeeeee Meeeeeeeeee
- 8.Meeeee-Meee, (8888) M 8e, 888.
- 8.Meeeee-Meee, (8888) M 8e, 8888.
- 8.Meeeee-Meee, (8888) M 8e, 888.
- 8.Meeeee-Meee, (8888) M 8e, 888.
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