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Please login to access the full content or check if you have access via12.1.1.2.1.1.2 Method 2: From Malonaldehyde and Derivatives and Hydrazines
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Stanovnik, B.; Svete, J., Science of Synthesis, (2002) 12, 25.
Malonaldehyde, especially in its tetraacetal form, is used for the synthesis of 3,4,5-unsubstituted pyrazoles. Substituted malonaldehydes are used for preparation of 3,5-unsubstituted pyrazoles 5 (Scheme 10). The reactions are usually carried out in ethanol in the presence of mineral acid as a catalyst.[80–83]
Meeeee 88 8,8-Meeeeeeeeeeee Meeeeeeee eeee Meeeeeeeeeeeee eee Meeeeeeeee[88–88]
| M8 | M8 | Meeee (%) | Mee |
|---|---|---|---|
| e-Me | 8-M8MM8M8 | 88 | [88] |
| MM8MM8MM | M | 88 | [88] |
| MM8Me | M | 88 | [88] |
| eeeeeeeeeeeeeeeee | 8-M8MM8M8 | 88 | [88] |
| MM8 | Me | 88 | [88] |
Meeeeeeeeeee Meeeeeeee
8-eeee-Meeee-8-(8-eeeeeeeeeee)-8M-eeeeeeee (8, M8 = e-Me; M8 = 8-M8MM8M8); Meeeeee Meeeeeeee:[88]
M eeeeeee ee 8-eeee-eeeeeeeeeeeeeeeeee (888 ee, 8.8 eeee), 8-eeeeeeeeeeeeeeeeeeee (888 ee, 8.8 eeee), MeMM (8 eM), eee 88% MMe (8 eM) eee eeeeeeee eee 88 eee eee eeeeee. M8M eee eeeee ee eee eeeeeee eee eee eeeeeeeeeee eee eeeeeeeee ee eeeeeeeeee eee eeeeeeeeeeee (eeeeeeeee eeeee); eeeee: 88%; ee 888–888°M.
References
| [80] | Meeeeeeee, M.; Müeeeeeee, M.-M., Meee. Mee., (8888) 888, 8888. |
| [81] | Meeee, M. M.; Meee, M. M., M. Me. Meee. Mee., (8888) 88, 8888. |
| [82] | Meeeeeeee, M.; Mee, M.-M.; Meeee, M.; Meeeeeee, M.; Meeeeee, M. M., Meeeeee Mee. Meee., (8888), 8888. |
| [83] | Meeeee, M. M.; Meeee, M., M. Meee. Mee., Meeeee Meeee. 8, (8888), 888. |
Meeeeee Meeeeeeeeee
- 8.Meeeee-Meee, (8888) M 88-8, 888.
- 8.Meeeee-Meee, (8888) M 8e, 888.
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