0 Hits

  • Previous / Next

You are using Science Of Synthesis as a Guest.
Please login or sign up for a free trial to access the full content. Method 2: From Malonaldehyde and Derivatives and Hydrazines

DOI: 10.1055/sos-SD-012-00002

Stanovnik, B.; Svete, J.Science of Synthesis, (20021225.

Malonaldehyde, especially in its tetraacetal form, is used for the synthesis of 3,4,5-unsubstituted pyrazoles. Substituted malonaldehydes are used for preparation of 3,5-unsubstituted pyrazoles 5 (Scheme 10). The reactions are usually carried out in ethanol in the presence of mineral acid as a catalyst.[‌80‌‌83‌]

Meeeee 88 8,8-Meeeeeeeeeeee Meeeeeeee eeee Meeeeeeeeeeeee eee Meeeeeeeee[‌88‌‌88‌]

Meeeeeeeeee 88

M8 M8 Meeee (%) Mee
e-Me 8-M8MM8M8 88 [‌88‌]
MM8MM8MM M 88 [‌88‌]
MM8Me M 88 [‌88‌]
eeeeeeeeeeeeeeeee 8-M8MM8M8 88 [‌88‌]
MM8 Me 88 [‌88‌]

Meeeeeeeeeee Meeeeeeee

8-eeee-Meeee-8-(8-eeeeeeeeeee)-8M-eeeeeeee (8, M8=e-Me; M8=8-M8MM8M8); Meeeeee Meeeeeeee:[‌88‌]

M eeeeeee ee 8-eeee-eeeeeeeeeeeeeeeeee (888ee, 8.8eeee), 8-eeeeeeeeeeeeeeeeeeee (888ee, 8.8eeee), MeMM (8eM), eee 88% MMe (8eM) eee eeeeeeee eee 88eee eee eeeeee. M8M eee eeeee ee eee eeeeeee eee eee eeeeeeeeeee eee eeeeeeeee ee eeeeeeeeee eee eeeeeeeeeeee (eeeeeeeee eeeee); eeeee: 88%; ee 888888°M.