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12.1.1.2.1.1.2 Method 2: From Malonaldehyde and Derivatives and Hydrazines

DOI: 10.1055/sos-SD-012-00002

Stanovnik, B.; Svete, J.Science of Synthesis, (20021225.

Malonaldehyde, especially in its tetraacetal form, is used for the synthesis of 3,4,5-unsubstituted pyrazoles. Substituted malonaldehydes are used for preparation of 3,5-unsubstituted pyrazoles 5 (Scheme 10). The reactions are usually carried out in ethanol in the presence of mineral acid as a catalyst.[‌80‌‌83‌]

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