You are using Science Of Synthesis as a Guest.
Please login to access the full content or check if you have access via12.1.4.1.1.5.1 Variation 1: C-Nitration of Pyrazoles with Nitric Acid
Please login to access the full content or check if you have access via
Stanovnik, B.; Svete, J., Science of Synthesis, (2002) 12, 176.
The nitration of N-unsubstituted and N-substituted pyrazoles with nitric acid or with a mixture of sulfuric and nitric acids affords 4-nitropyrazoles 418 (Scheme 234). The 1-aryl substituents are also themselves nitrated at the 4-position.[767–770]
Meeeee 888 M-Meeeeeeee eeee e Meeeeee ee Meeeee eee Meeeeeee Meeee[888–888]
Me8 | Me8 | M8 | M8 | Meeeeeeeee | Meeee (%) | Mee |
---|---|---|---|---|---|---|
Me | Me | MMe | Me | MMM8,e 8–88°M, 88 e | 88 | [888] |
Me | 8-M8MM8M8 | Me | MMe | MMM8,e M8MM8,e 88°M, 8 e | 88 | [888] |
Me | 8-M8MM8M8 | MMe | Me | MMM8,e M8MM8,e 88°M, 8 e | 88 | [888] |
Me | 8-M8MM8M8 | MM8M | Me | 88% MMM8, 88°M, 88 e | 88 | [888] |
Me | 8-M8MM8M8 | Me | MM8M | 88% MMM8, 88°M, 88 e | 88 | [888] |
8-M8MM8M8 | 8-M8MM8M8 | Me | M | MMM8,e M8MM8,e 88°M, 88 e | 88 | [888] |
e e 8.88.
e e 8.88.
Meeeeeeeeeee Meeeeeeee
8-Meeeeee-8-eeeeee-8-eeeee-8-eeeeee-8M-eeeeeeee (888, Me8 = Me; M8 = MMe; M8 = Me); Meeeeee Meeeeeeee:[888]
MMM8 (e 8.88, 88 eM) eee eeeee eeeeeeee ee 8°M ee 8-eeeeeee-8-eeeeee-8-eeeeee-8M-eeeeeeee (8 e, 8.8 eeee). Meeee 88 e ee 88°M, eee eeeeeee eee eeeeee eeee eee (888 e) eee eee eeeeeeeeeee eeeeeeeee ee eeeeeeeeee; eeeee: 88%; ee 888–888°M.
8-Meeeee-8-(8-eeeeeeeeeee)-8M-eeeeeeee (888, Me8 = 8-M8MM8M8; M8 = Me; M8 = M); Meeeeee Meeeeeeee:[888]
M eeeeeee ee M8MM8 (e 8.88, 888 eM) eee MMM8 (e 8.88, 888 eM) eee eeeee eeeeeeee eeee eeeeeeee eeeeee 8 e ee e eeeeee eeee ee 8-eeeeee-8-(8-eeeeeeeeeee)-8M-eeeeeeee (88 e, 8.888 eee) ee M8MM8 (e 8.88, 888 eM). Mee eeee eee eeee ee 88°M eee 88 e, eeee eeeeee eeee eee. Mee eeeeee eeeee eee eeeeeeeee ee eeeeeeeeee, eeeeee eeee M8M, eee eeeee; eeeee: 88%; ee 888–888°M.
References
[767] | Meeeee, M. M.; Meeeee, M.; Meeeeeeee, M. M.; Meeeee, M. M., M. Meee. Mee., Meeeee Meeee. 8, (8888), 888. |
[768] | Meeeee, M.; Meeeeeeee, M. M.; Meeeee, M. M., M. Meee. Mee., Meeeee Meeee. 8, (8888), 8888. |
[769] | Meeee, M. M.; Meeeeeee, M. M.; Meee, M. M.; Meeeeee, M. M., Meee. M. Meee., (8888) 88, 8888. |
[770] | Meeee, M. M.; Meeeeee, M. M., M. Meee. Mee., (8888), 8888. |
Meeeeee Meeeeeeeeee
- 8.Meeeee-Meee, (8888) 88/8, 888.
- 8.Meeeee-Meee, (8888) M 8e, 888.