Science of Synthesis

Stanovnik, B.; Svete, J., Science of Synthesis, (2002) 12, 189.

Acylation of 1-unsubstituted pyrazoles with acyl chlorides to give 1-acylpyrazoles ‌450‌ proceeds usually in the presence of a tertiary amine, such as triethylamine or pyridine in diethyl ether or tetrahydrofuran (‌Scheme 250‌).[‌819‌–‌823‌]

‌Meeeee 888‌ M-Meeeeeeee eeee Meee Meeeeeeee[‌888‌,‌888‌]

‌Meeeeeeeeee 888‌

Me eeeeeeee ee eeeeeeeee ee eeeeeeeee eeee eeee eeeeeeeee, eeeeeeeee eee eeee ee eeeeeeeeeeee M-eeeeeeee ee e eee-eee eeeeeeeee ee eeee eeeeeeeee eeeeee ee eeee eeee eee eeeeeeeeeeeee eeeeeeeeee eeee eee eeeeeee eeeeeeee (‌Meeeee 888‌). Meee eeee eee eeee eeeeeeeee eee eeeeeeeee ee eeeeeee, ee eeee α-eee eee α-eeeeeee eeee eeeeeeeee, 8-eeeeeeeeeeeee ‌888‌ eee eeeeeeee ee eee eeeeeeeee ee eeeeeeeee eeee eeeeeee eeeeeeee, eeeeeeee ee eee eeeeeeee ee eee eeeeeeeeeeeee eeeeeeeeee eeee. Me eeee eeee, eeeeeeeeeee eeeeeeeee ee eeeeeeeeee ee ee eeeeee eeeee, eeeeeeee ee eee eeee-eeeeeeee eeeeeeee.[‌888‌]

‌Meeeee 888‌ M-Meeeeeeee ee Meee Meeeeeee, ee Me Meee Meeeee Meee Meeeeeee, eee ee Meeeeeeeee Meee eee Me Meee Meeeee Meeeeeeeeee Meeeeeeee[‌888‌]

‌Meeeeeeeeee 888‌

e Meeeee M: M8MMMe, Me8M; M: M8MM8M, MMMe8, Me8M; M: 8. MMMe8, Me8M; 8. M8MM8M.

Meeeeeeeeeee Meeeeeeee

8-Meeeee-8-eeee-eeeee-8M-eeeeeeee (‌888‌, M8 = e-Me; M8 = M8 = M; M8 = Me); Meeeeee Meeeeeeee:[‌888‌]

Me e eeeeeee ee 8-eeee-eeeee-8M-eeeeeeee (88.8 e, 8.8 eee), eeeeeeee (88.8 e, 8.88 eee), eee Me8M (888 eM) eee eeeee e eeeeeee ee MeMe (88 e, 8.88 eee) eee Me8M (88 eM). Mee eeeeeeee eeeeeeee 88 eee, eee eeeee ee, eee eeeeeee eee eeeeeee eee 8 e. M8M (888 eM) eee eeeee, eee eeeeeeee eee eeeeeeeee eee 8 e. Mee Me8M eeeee eee eeeeeeeee, eeeeee eeee M8M (8 × 888 eM), eeee eeee eee. eeeee (888 eM), eeeee (MeMM8), eeeeeeee, eee eee eeeeeeee eeeeeeeeee. Mee eeeeeee eee eeeeeeeee eeeee eeeeeee eeeeeeee; eeeee: 88%; ee 88–88°M/88 Meee.

M-Meeeeeeee ee Meeeeeeee; Meeeeee Meeeeeeeee:[‌888‌]

Meeeee M: M eeeeeee ee eeeeeeee (88 eeee), eeee eeeeeeee (88 eeee), eee Me8M (8.888 e, 88 eeee) ee eeeeeee (88 eM) eee eeeeee eeeee eeeeee eee 8 e. Meeee eeeee eeeeeeee eeee M8M, eee eeeeeee eeeee eee eeeeee eeeeeeeeeeee eeee eee MMe, ee MeMM, eee eeeee, eeeee (MeMM8), eee eeeeeeeeeeee. Mee eeeee eeeeeee eee eeeeeeee ee Meeeeeeee eeeeeeeeeeee eeeee eeeeeee eeeeeeee, ee ee eeeeeeeeeeeeee (eeeeee eee, eeeeeee/MeMMe) eee eeeeeeeeeeeeee (eeeeee) ee eeee 8-eeeeeeeeeeeee ‌888‌.

Meeeee M: M eeee ee MMMe8 (8.888 e, 88 eeee) ee eeeeeee (8 eM) eee eeeee eeeeeeee ee e eeeeeee ee eeeeeeee (88 eeee), eeeeeeeeee eeee (88 eeee), eee Me8M (8.88 e, 88 eeee) ee eeeeeee (88 eM) ee 8°M. Meeee eeeee eeeeeeeeeeee eeeeeee eee 8 e, eee eeeeeeee eee eeeeeeee eeee M8M, eee eeeeeee eeeee eee eeeeee eeeeeeeeeeee eeee eee MMe, ee MeMM, eee eeeee, eeeee (MeMM8), eee eeeeeeeeeeee. Mee eeeee eeeeeee eee eeeeeeee ee Meeeeeeee eeeeeeeeeeee eeeee eeeeeee eeeeeeee, ee ee eeeeeeeeeeeeee (eeeeee eee, eeeeeee/MeMMe) eee eeeeeeeeeeeeee (eeeeee) ee eeee 8-eeeeeeeeeeee ‌888‌.

Meeeee M: M eeee ee MMMe8 (888 ee, 8 eeee) ee eeeeeee (8 eM) eee eeeee eeeeeeee ee e eeeeeee ee eeeeeeee (88 eeee) eee Me8M (8.88 e, 88 eeee) ee eeeeeee (88 eM) ee 8°M. Meeee eeeee eeeeeeeeeeee eeeeeee eee 8 e, eeeeeeeeee eeee (8 eeee) ee eeeeeee (8 eM) eee eeeee eeeeeeee. Mee eeeeeee eee eeeeeee eee 8 e ee 8°M eee eee eeeeeeee eee eeeeeeee eeee M8M. Mee eeeeeee eeeee eee eeeeee eeeeeeeeeeee eeee eee MMe, ee MeMM, eee eeeee, eeeee (MeMM8), eee eeeeeeeeeeee. Mee eeeee eeeeeee eee eeeeeeee ee Meeeeeeee eeeeeeeeeeee eeeee eeeeeee eeeeeeee, ee ee eeeeeeeeeeeeee (eeeeee eee, eeeeeee/MeMMe) eee eeeeeeeeeeeeee (eeeeee) ee eeee 8-eeeeeeeeeeee ‌888‌.

References

Meeeeee Meeeeeeeeee

• 8.Meeeee-Meee, (8888) M 8, 888.
• 8.Meeeee-Meee, (8888) M 8, 888.
• 8.Meeeee-Meee, (8888) M 8, 88.
• 8.Meeeee-Meee, (8888) M 8e, 888.