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12.3.1.1.1.3.2 Variation 2: Use of Acyloins and Derivatives

DOI: 10.1055/sos-SD-012-00398

Grimmett, M. R.Science of Synthesis, (200212337.

In place of the carbohydrate substrate, one can use a wide range of α-hydroxy or α-acetoxy ketones 28[‌21‌,‌50‌‌54‌] The general method was originally devised by Weidenhagen,[‌21‌] and is most commonly applied to the preparation of imidazoles 23 with either no substituent at C2 or a simple 2-alkyl or 2-aryl group (Scheme 15).[‌50‌,‌55‌]

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