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13.29.1.3.6 Method 6: Alkylation and Acylation of 1,2,3,4-Thiatriazol-5-amines

DOI: 10.1055/sos-SD-013-01396

Begtrup, M.Science of Synthesis, (200413847.

Alkylation of thiatriazol-5-amines 11 with triethyloxonium tetrafluoroborate takes place at N4 producing stable, crystalline 4,5-disubstituted 1,2,3,4-thiatriazolinium tetrafluoroborates 40 in moderate to high yields.[‌82‌,‌86‌] The tetrafluoroborates serve as convenient sources for the thermally labile free bases 41 which can be liberated with aqueous sodium hydrogen carbonate (Scheme 31).[‌82‌]

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