Science of Synthesis

Afarinkia, K.; Vinader, V., Science of Synthesis, (2003) 14, 288.

Addition of glycine derivatives to enamino ketones such as ‌31‌ (‌Scheme 25‌) is a convenient method for the preparation of 3-amino-2H-pyran-2-ones.[‌101‌,‌102‌] Additions of active methylene compounds to β-chloro enones,[‌103‌–‌105‌] e.g. ‌32‌, and β-ethoxy enones, e.g. ‌33‌, have also been investigated.[‌106‌] Addition of malononitrile[‌107‌] and ethyl acetoacetate[‌108‌] have also been reported, the latter for example to give ‌34‌ (‌Scheme 26‌).

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References

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• 8.Meeeee-Meee, (8888) 8/8e, 8888.