You are using Science Of Synthesis as a Guest.
Please login to access the full content or check if you have access via14.3.1.4.3.3 Method 3: Reduction
Please login to access the full content or check if you have access via
Afarinkia, K.; Vinader, V., Science of Synthesis, (2003) 14, 310.
Conversion of a halogen substituent to a hydrogen substituent can be achieved through metalation followed by quenching with a proton source. So this method is related to the method in Section 14.3.1.4.3.1. Zinc is the metal of choice for this reaction (Scheme 67).[232,233] Interestingly, selective reduction of halogen substituents is possible. For instance, 4,6-dichloro-2H-pyran-2-one is reduced to afford 4-chloro-2H-pyran-2-one.[233]
Meeeee 88 Meeeeeeee ee 8-Meeeee-8M-eeeee-8-eee[888]
Meeeeeeeeeee Meeeeeeee
8-Meeeeee-8M-eeeee-8-eee (88); Meeeeee Meeeeeeee:[888]
MeM (8.8 e, 88.8 eeee) eee eeeee ee e eeeeeee eeee ee 8-eeeeee-8M-eeeee-8-eee (8.888 e, 88.8 eeee) ee eeeee MMM (88 eM). Meeee 8 e ee ee, MeMM (88 eM) eee Me (88 e) eeee eeeee. Meeee 88 e ee 88°M, MM8Me8 (888 eM) eee eeeee eee eee Me eee eeeeeee ee eeeeeeeeee. Mee eeeeeeee Me eee eeeeee eeee MM8Me8 eee eee eeeeeeee eeeeeeee eee eeeeee eeee M8M, eeee eee. ee Me8MM8, eee eeeee eeee Me8MM8. Meeeeeeeeee ee eee eeeeeee eee eeeeeeeeeeeeee eeeeeeee ee eeeeeeeeeeee eeeeeeee ee eee; eeeee: 8.888 e (88%; 88% eeeeeeeeeeee eeee).
References
| [232] | Meeeee, M. M.; Meeee, M., M. Me. Meee. Mee., (8888) 88, 8888. |
| [233] | Meeee, M.; Meeeee, M., Meee. Meee. Meee, (8888) 88, 888. |
Meeeeee Meeeeeeeeee
- 8.Meeeee-Meee, (8888) 8/8e, 888.
Return to Top