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Please login to access the full content or check if you have access via Method 4: Rearrangement of [(2-Hydroxybenzylidene)amino]acetates and N′-(2-Hydroxybenzylidene)acetohydrazides

DOI: 10.1055/sos-SD-014-00294

Williams, A. C.; Camp, N.Science of Synthesis, (200314372.

The products, e.g. 7274, derived from these reactions all bear a substituent at the 3-position, derived from the amine or hydrazine coupling partner. The reactions probably proceed first through formation of the 12 bond, cleavage of the imino functionality and closure of the 34 bond in an intramolecular Knoevenagel reaction. Functional groups may be introduced at the 58 positions by appropriate choice of 2-hydroxybenzaldehyde (Scheme 23).[‌151‌,‌169‌,‌170‌]

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