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14.4.10.1.1.4.1.1.5 Variation 5: Intramolecular Friedel–Crafts Acylation via Mixed Anhydride Formation

DOI: 10.1055/sos-SD-014-00294

Williams, A. C.; Camp, N.Science of Synthesis, (200314602.

A variety of reagents are used to achieve the FriedelCrafts acylation of 2-phenoxybenzoic acids via mixed anhydride formation. Examples are highlighted in Scheme 265 and include sulfuric acid and acetic anhydride,[‌985‌,‌1036‌] sulfuric acid and acetyl chloride,[‌1037‌] and trifluoroacetic acid and trifluoroacetic anhydride.[‌1038‌] In these reactions, yields of the 9H-xanthen-9-ones 683 are generally good.

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