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15.1.1.1.4.2.1.2 Variation 2: From Malononitrile and 1,1-Diethoxy-N,N-dimethylalkanamines or ­Orthoformates

DOI: 10.1055/sos-SD-015-00002

Spitzner, D.Science of Synthesis, (20051532.

2-Amino-6-chloropyridine-3,5-dicarbonitrile (80) is formed in 10% yield, along with [(dimethylamino)methylene]malononitrile (30%), from malononitrile and N-(diethoxymethyl)-N,N-dimethylamine (79) upon heating in ethanol and concentrated hydrogen chloride for 45 minutes (Scheme 28).[‌140‌]

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