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DOI: 10.1055/sos-SD-015-00002

Spitzner, D.Science of Synthesis, (20051537.

2,6-Disubstituted 4-aminopyridine-3-carbonitriles, e.g. 103, are formed from β-(lithioamino)acrylonitriles and acylketene N,S-acetals; the methylsulfanyl group is eliminated from the intermediate dihydropyridine. 3-(Lithioamino)but-2-enenitrile (102) is prepared in situ from acetonitrile with butyllithium in tetrahydrofuran at 78°C (Scheme 36).[‌162‌]

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