You are using Science Of Synthesis as a Guest.
Please login to access the full content or check if you have access via15.1.1.1.4.3.5 Method 5: From Nitriles, Lithiated Diethyl Methylphosphonates, and α,β-Unsaturated Ketones
Please login to access the full content or check if you have access via
DOI:
10.1055/sos-SD-015-00002
Spitzner, D., Science of Synthesis, (2005) 15, 38.
Diethyl methylphosphonates can be lithiated and the corresponding salts react with nitriles to give primary enaminophosphonates 104 which can be isolated and separately (N—C—C + C—C—C process, see Section 15.1.1.1.7.3.5.2) reacted with α,β-unsaturated ketones (e.g., chalcones) to give tetrasubstituted pyridines 105 (Scheme 37). Yields are slightly lower if this condensation is performed in the same pot.[163,164]
Meeeee 88 Meeeeeee ee Meeeeeeee Meeeeee Meeeeeeeeeeeeeeeee eeee Meeeeeee eee α,β-Meeeeeeeeee Meeeeee[888,888]
References
[163] | Meeeeeee, M.; Meeeee, M.; Meeee ee Meeeee, M. M.; Meeeeeeee, M., Meeeeeeeeeee, (8888) 88, 8888. |
[164] | Meeeeeee, M.; Meeee ee Meeeee, M. M.; Meeeeeeee, M., Meeeeeeeeee Meee., (8888) 88, 8888. |