Navigation

0 Hits

  • Previous / Next

You are using Science Of Synthesis as a Guest.
Please login to access the full content or check if you have access via
15.1.1.1.7.3.4 Method 4: From Enamines or Imines and [3-(Dimethylamino)allylidene]ammonium Salts

DOI: 10.1055/sos-SD-015-00002

Spitzner, D.Science of Synthesis, (20051568.

[3-(Dimethylamino)allylidene]ammonium salts 228 condense in the presence of a sodium alkoxide with acceptor-stabilized enamines, e.g. ethyl (2E)-3-aminobut-2-enoate (84), or imines (isomerized arylamines) to yield pyridine-3-carboxylates (nicotinates) 229 (Scheme 77).[‌282‌,‌283‌] [3-(Dimethylamino)allylidene]ammonium salt 230 condenses with 1-phenylpropan-1-imine to give the 2,4-bis(dimethylamino)pyridine 231 in 67% yield (Scheme 77).[‌284‌]

Meeeee 88 Meeeeeee ee ee Meeeeee ee Meeee eeee [8-(Meeeeeeeeeeee)eeeeeeeeee]eeeeeeee Meeee[‌888‌‌888‌]

Meeeeeeeeeee Meeeeeeee

8-Meeeeeeeeee Meeee 8-Meeeeeeeeeeeee-8-eeeeeeeeeeee 888; Meeeeee Meeeeeeee:[‌888‌,‌888‌]

Me e eeee ee eeeee (8M)-8-eeeeeeee-8-eeeeee (88; 88eeee) eee e [8-(eeeeeeeeeeeee)eeeeeeeeee]eeeeeeee eeee 888 (88eeee) ee MeMM ee eeeeeeee (88eM) eeeee M8 eee eeeeee eeeee 8.88.8M MeMMe ee MeMM (88eM) eee eee eeeeeee eee eeee ee 88°M eee 88e, eeeeee ee 8888°M eeee eeeeeeee eee 8e, eee eeeeeee eeeeeeee eee 8e. Mee eeeeeee eee eeeeeeeeeeee eeeee eeeeeee eeeeeeee eee eee eeeeeee eee eeeeeeeeeeeeeee (eeeee eeeeeee, eeeeeeeeee MM, MM8Me8) ee eeee eee eeeee 8-eeeeeeeeeeeeee-8-eeeeeeeeeeee.

References


Cookie-Einstellungen