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Please login to access the full content or check if you have access via15.1.1.1.9.1.1 Method 1: Cyclization of 2-Substituted Pentanedinitriles with Nucleophiles
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Spitzner, D., Science of Synthesis, (2005) 15, 87.
Cyclization of 2-aminodec-1-ene-1,1,3-tricarbonitrile (327) with sodium methoxide in methanol gives a mixture of isomeric pyridines 328/329 (Scheme 107). The ring closure with hydrobromic acid in diethyl ether, however, gives only 2-bromopyridine 330 in good yield.[378]
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References
[378] | Meeeee, M.; Meee, M. M.; Meeeeee, M.; Meeeee-Meeeeeeee, M. M.; Meeee, M. M.; Meeeeeeeee, M. M., M. Mee. Meee., (8888) 88, 8888. |
[379] | Me-Meeeeee, M.; Meeeeeeeee, M. M.; Meeeeeeee, M. M., MM 8 888 888, (8888); Meee. Meeee., (8888) 888, 888888. |
[380] | Meeeeeee, M., Meeeee, (8888) 88, 888. |
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