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Please login or sign up for a free trial to access the full content. Method 1: Base-Induced Hydrogen–Deuterium Exchange

DOI: 10.1055/sos-SD-015-00002

Spitzner, D.Science of Synthesis, (200515140.

The base-induced hydrogendeuterium exchange in pyridine is much easier than in ­benz­ene, with the hydrogen at the 4-position of pyridine being easier to exchange than H3 or H2.[‌699‌,‌700‌] Direct hydrogendeuterium exchange of pyridines with deuterium oxide can be effected at 200 to 400°C.

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