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15.1.1.4.1.1.7.1 Method 1: Nitration

DOI: 10.1055/sos-SD-015-00002

Spitzner, D.Science of Synthesis, (200515153.

Electrophilic aromatic substitution of pyridine is possible under forcing conditions. Direct nitration of pyridine with concentrated nitric acid gives 3-nitropyridine in low (15%) yield. Better yields can be achieved with heterocycles which bear electron-donating groups.[‌787‌‌789‌]

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