Science of Synthesis

Spitzner, D., Science of Synthesis, (2005) 15, 155.

Elemental fluorine reacts with pyridine (‌1‌) in wet acetonitrile at −40°C to give N-acetylpyridin-2-amine (‌654‌) and a small amount of 2-fluoropyridine (‌637‌) (‌Scheme 217‌). The reaction carried out in wet butanenitrile provides N-butanoylpyridin-2-amine in 58% yield.[‌799‌]

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